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Biomedical subjects

E A Nelson

Publications and source records attributed to E A Nelson.

At least 127 records · Page 7Linked to original sources
PubMed1990

Plunket contacts in the first year of life.

In New Zealand, routine infant health surveillance is carried out by the nurses of the Royal New Zealand Plunket Society. The full scheduled number of contacts for the first year of life was 15. The pattern of these nurse contacts was examined during the first year of life for babies born between 1979 to 1984. Data was available for 492 randomly selected infants. There was no record of any Plunket contact in 102 (20.7%). Of those infants who had some Plunket contact, only 71 (19.4%) had the full number of contacts or more, and 51 (13.9%) had only seven or fewer contacts. Infants with a high Christchurch-Invercargill-Dunedin (CID) birthscore were more likely not to have any contacts, and when contact was made these infants were seen less often than compared to the low risk group, during this period. More stringent efforts are needed to engage those infants who are at present not being seen, as they appear to be the infants who are most at risk.

Age Factors↗
PubMed1990

Prediction of possibly preventable death: a case-control study of postneonatal mortality in southern New Zealand.

The postneonatal mortality rate in three southern regions of New Zealand was 8.1 per 1000 live births for 1979-1984. The possibly preventable postneonatal mortality rate was 7.1 per 1000 live births and data on 377 possibly preventable deaths and 936 randomly selected controls were used to develop a two-stage risk-scoring system. Logistic regression analysis was undertaken separately on two sub-samples of the total sample. The data were used to evaluate three other previously published scoring systems. The four variables used in our birth score (mother's age, parity, marital status, and birth weight) have all appeared in other scoring systems, and this score could identify a group of infants in southern New Zealand with an estimated 1.7% mortality rate in the first year of life. It is suggested that currently the only valid use of risk-scoring in this region is for the definition of a high-risk population for the purpose of evaluating potential intervention strategies.

Case-Control Studies↗
PubMed1990

Growth velocity before sudden infant death.

Weight velocities of 136 infants who died from sudden infant death syndrome (SIDS) were compared with those of 136 controls matched for sex, birth weight, and type of feeding. It was found that the SIDS infants gained weight more slowly overall and that the differences were significantly different for infants who were not breast fed in the last two weeks in which it was possible to estimate their growth velocity. Breast fed infants had more periods of growth below the 25th centile than expected. These differences are unlikely to be useful in the prediction of which babies are likely to die from SIDS as there are frequent episodes of poor growth in infants who do not die.

Birth Weight↗
PubMed1990

Relative prevalence of typical and atypical strains among rotaviruses from diarrheic pigs in conventional swine herds.

Polyacrylamide gel electrophoresis was conducted on genomic RNA extracted from rotaviruses detected in diarrheic pigs from conventional swine herds. Ninety samples contained sufficient virus for RNA band visualization and genome classification. Genome profiles were characteristic of typical group A rotaviruses in 67.8% of the 90 samples, of group B rotaviruses in 10.0%, and of group C rotaviruses in 11.1%. In 11.1% of the samples, the presence of more than 11 bands suggested concurrent infection with more than 1 strain of rotavirus. In infections among nursing pigs, 76.4% were group A rotaviruses, 7.4% were group B, 7.4% were group C, and 8.8% were coinfections. In infections among weaned pigs, 40.9% were group A, 18.2% were group B, 22.7% were group C, and 18.2% were coinfections. Coelectrophoresis with prototype OSU and Gottfried strains revealed a great diversity in electropherotype among field strains of rotavirus.

Animals↗
PubMed1989

Sleeping position and infant bedding may predispose to hyperthermia and the sudden infant death syndrome.

Southern New Zealnd has one of the highest postneonatal mortality rates in the developed world (8.1/1000 livebirths) and 77% of these deaths are attributed to the sudden infant death syndrome (SIDS). Both hyperthermia and sleeping position have previously been implicated in SIDS. A theoretical model to estimate the thermal balance of infants used here shows that the head, and particularly the face, becomes the main route for heat loss when thick clothing and bedding are used. This thermoregulatory role could be compromised by the prone sleeping position. It is postulated that particular cultural combinations of infant care practices (sleeping position, clothing, bedding, and room heating) may facilitate hyperthermia and explain widely disparate rates of SIDS in different countries and ethnic groups.

Bedding and Linens↗
PubMed1989

Infant clothing, bedding and room heating in an area of high postneonatal mortality.

Documentation of infant care practices (clothing, bedding and room heating) was undertaken in an area where the postneonatal mortality rate is 9.3 per 1000 live births. Three hundred and eleven infants (mean age 5 weeks) were studied in their own home during winter and spring. Low room temperatures were associated with low socioeconomic status, but not consistently with clothing or bedding thicknesses. The estimated thickness of bedding covering infants was less if their mothers were less well educated. Infants at high risk for possibly preventable postneonatal mortality, based on a locally developed scoring system, had less bedding and colder rooms. Ideas of illness management were often inappropriate, in that a large number of mothers would further wrap up their infants if they had a cold (58%), were febrile (8%) or had a convulsion (21%). The clothing and bedding appropriate for different environmental conditions in health and illness needs physiological evaluation. Meanwhile parents should be reminded of the risk of both hypothermia and hyperthermia.

Bedding and Linens↗
PubMed1989

Postneonatal mortality in south New Zealand: necropsy data review.

Three southern New Zealand health districts had a postneonatal mortality rate of 8.1 per 1000 livebirths and a postneonatal sudden infant death syndrome (SIDS) mortality rate of 6.3 per 1000 livebirths for the period 1979-1984. This is one of the highest reported rates of SIDS. The 429 postneonatal deaths occurring during the period were assigned to one of four groups: unpreventable (n = 52), possibly preventable non-SIDS (n = 45), SIDS with minor abnormalities at necropsy or premorbid symptoms (n = 167), and SIDS with no abnormalities at necropsy or documented premorbid symptoms (n = 165). These groups were related to obstetric and perinatal data. For those infants classified as SIDS, the winter peak of deaths was particularly marked if death occurred after 3 months of age. These older SIDS deaths had more minor abnormalities at necropsy, a longer interval between time last seen or heard alive and found dead and more thymic petechiae.

Cause of Death↗
PubMed1989

Child care practices and the sudden infant death syndrome.

Southern New Zealand has one of the highest reported rates of the sudden infant death syndrome (SIDS) in the world. Data were collected on 49 infants who died from SIDS in the Dunedin and Invercargill Health Districts of southern New Zealand. Forty-two of the families were interviewed at home following the loss of their infant. In the week prior to death, 17 infants (40%) had an upper respiratory tract infection, although in 11 of these infants their infection had apparently resolved at least 24 h prior to death. Thirty infants (71%) had their faces down into the bedding or their heads covered with bedding. Thirty-four infants (81%) were found dead in the prone position, whereas 49% of New Zealand infants aged 3 months would be expected to sleep prone. Sleep position and the terminal position of the head in relation to SIDS requires further study.

Humans↗
PubMed1988

Climatic and social associations with postneonatal mortality rates within New Zealand.

There is considerable regional variation in postneonatal mortality rates within New Zealand. The majority of postneonatal deaths are recorded as sudden infant death syndrome, and the regional rates of these deaths show a significant negative correlation with the mean daily temperature and mean 0900 hr vapour pressure (p less than 0.001). Postneonatal mortality rates, excluding sudden infant death syndrome mortality, show significant positive correlation with the regional percentage of the population of Maori descent (p less than 0.001). Further investigation of environmental temperature or factors closely related to it may shed light on the aetiology of the sudden infant death syndrome.

Climate↗
PubMed1988

Haemorrhagic shock encephalopathy syndrome.

Haemorrhagic shock encephalopathy syndrome is a recently described condition which appears to be an important cause of infant mortality and morbidity. Six infants, with some features of this condition, admitted to Dunedin Hospital during the last three years, are presented and their diagnoses reviewed. Diagnostic overlap may occur between haemorrhagic shock encephalopathy syndrome, hypoxic-ischaemic encephalopathy and near miss sudden infant death syndrome. An investigative approach to the infant with shock and acute encephalopathy is outlined.

Brain Diseases↗
PubMed1984

Comparison of a commercial enzyme-linked immunosorbent assay with electron microscopy, fluorescent antibody, and virus isolation for the detection of bovine and porcine rotavirus.

The purpose in this study was to compare the sensitivity of a commercial enzyme-linked immunosorbent assay (ELISA) with electron microscopy (EM), fluorescent antibody (FA), and virus isolation (VI) for the detection of bovine and porcine rotavirus (RV). Seventy-three bovine and 116 porcine accessions were evaluated by 1 or all 4 diagnostic tests, where suitable specimens were available. For the bovine samples, agreement was 33% between FA and EM, 33% between FA and ELISA, and 92% between EM and ELISA. For the porcine samples, agreement was 79% between EM and FA, 72% between EM and ELISA, and 82% between ELISA and FA. Virus was isolated from 68% and 41% of the bovine and porcine fecal samples, respectively. Commercial ELISA was as sensitive as EM, but was more sensitive than FA or VI for the detection of RV in bovine feces. Electron microscopy was more sensitive than FA, ELISA, or VI for detection of RV in porcine feces. The ELISA was an advantageous alternative to the conventional methods of EM, FA, and VI for the diagnosis of RV in calf feces, but not for porcine feces.

Animals↗
PubMed1982

Seasonal variation in seminal and testicular characteristics of Brazilian Somali rams in the hot semi-arid climate of tropical northeast Brazil.

The seasons in the 1 year study were classified as rainy, transitional rainy-dry, dry, and transitional dry-rainy. Semen pH and the consistency of the testes did not vary between seasons or among rams. All other characteristics of semen and testis varied between rams. Significant seasonal differences were observed for ejaculate volume, mass, % motility, forward motility score and concentration of spermatozoa, and linear testis measurements. The total number of spermatozoa per ejaculate did not vary seasonally. The magnitude of the seasonal effects was not sufficient to prevent the rams being used for breeding throughout the year.

Animals↗
PubMed1980

Candidal abscess of the spleen in patients with acute leukemia.

Between January 1974 and July 1976, three adult patients with leukemia, therapy-associated granulocytopenia and febrile courses unresponsive to broad spectrum antibiotic therapy were operated upon for a preoperative diagnosis of candidal abscess of the spleen. The diagnosis was based upon a high index of suspicion of invasive candidiasis in this immunosuppressed group of patients; the failure of the patients to respond to the empiric administration of broad spectrum antibiotics, salicylates and steroids, and the presence of discrete scintiscan defects on liver-spleen scan with both 99Tc sulfur colloid and 67Ga citrate. Multiple splenic abscesses containing candidal organisms were confirmed in all three patients, and two of the three also had multiple small abscesses of the liver. The fourth patient, whose liver-spleen scintiscans were abnormal only in showing splenomegaly and whose febrile course responded to aspirin, did not have a candidal abscess of the spleen at the time of celiotomy which was undertaken for fever of unknown cause. The antemortem diagnosis and treatment of candidal splenic abscess in patients with leukemia is dependent upon a high index of suspicion and appropriate clinical correlation with diagnostic tests. Although the prophylactic oral administration of mycostatin to patients at high risk may prevent this once fatal complication, only prompt and aggressive treatment can cure it.

Abscess↗
PubMed1967

Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate.

Pertussis vaccines preserved with 0.01% Merthiolate are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms. The toxicities of both Merthiolate (0.01%)-preserved and unpreserved vaccines increased when the number of organisms injected was increased. An increase in mortality was observed when Merthiolate was injected separately, before or after an unpreserved saline suspension of pertussis vaccine.

Animals↗