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Biomedical subjects

E A Morozova

Publications and source records attributed to E A Morozova.

14 recordsLinked to original sources
PubMed1998

Mapping quantitative trait loci affecting sternopleural bristle number in Drosophila melanogaster using changes of marker allele frequencies in divergently selected lines.

Quantitative trait loci (QTLs) responsible for variation in sternopleural bristle number in crosses between the laboratory lines of Drosophila melanogaster OregonR and CantonS were mapped using information from allele frequency changes of two families of retrotransposon markers in divergently selected populations. QTL effects and positions were inferred by likelihood, using transition matrix iteration and Monte Carlo interval mapping. Individuals from the selected population were genotyped for markers spaced at an average distance 4.4 cM. Four QTLs of moderate effect ranging from 0.6 to 1.32 bristles accounted for most of the selection response. A permutation test of the correspondence between the mapped QTLs and the positions of bristle number candidate genes suggested that alleles at these candidate genes were no more strongly associated with selected changes in marker allele frequency than were randomly chosen positions in the genome.

Alleles↗
PubMed1998

Quantitative genetic analysis of copia retrotransposon activity in inbred Drosophila melanogaster lines.

The rates of transcription and transposition of retrotransposons vary between lines of Drosophila melanogaster. We have studied the genetics of differences in copia retrotransposon activity by quantitative trait loci (QTL) mapping. Ninety-eight recombinant inbred lines were constructed from two parental lines exhibiting a 10-fold difference in copia transcript level and a 100-fold difference in transposition rate. The lines were scored for 126 molecular markers, copia transcript level, and rate of copia transposition. Transcript level correlated with copia copy number, and the difference in copia copy number between parental lines accounted for 45.1% of copia transcript-level difference. Most of the remaining difference was accounted for by two transcript-level QTL mapping to cytological positions 27B-30D and 50F-57C on the second chromosome, which accounted for 11.5 and 30.4%, respectively. copia transposition rate was controlled by interacting QTL mapping to the region 27B-48D on the second and 61A-65A and 97D-100A on the third chromosome. The genes controlling copia transcript level are thus not necessarily those involved in controlling copia transposition rate. Segregation of modifying genes, rather than mutations, might explain the variability in copia retrotransposon activity between lines.

Animals↗
PubMed1984

[Mitochondrial pathology].

Three adult patients with mitochondrial disease underwent clinical-morphological studies which demonstrated a diffuse and marked defect in mitochondria. The characteristic clinical picture of "ophthalmoplegia plus", a slow progression of the disease, the quantitative and structural changes in the mitochondria of muscle fibers justified the diagnosis of mitochondrial disease.

Adolescent↗
PubMed1980

[Lipid metabolism disorder in skeletal musculature (carnitine palmitoyltransferase deficiency) and paroxysmal myoglobinuria].

For the first time in Soviet medical literature a patient with an insufficiency of carnitine palmityl transferase (CPT) in skeletal muscles is described. The disease manifested itself in repeated attacks of severe muscular pains and myoglobinuria developing after long-time muscular efforts. The patient showed a persistent rise of the serum levels of free fatty acids, beta-lipoproteids and triglycerides, as well as a rise of the triglyceride level in the course of a 3-day fasting, the fact rather characteristic of muscular CPT insufficiency. The presence of myoglobin in the serum and the urine was confirmed by electrophoresis on paper and cellulose acetate. The pathogenesis of the disease, and problems of its differential diagnosis and treatment are discussed.

Acyltransferases↗