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Biomedical subjects

E A Luce

Publications and source records attributed to E A Luce.

At least 19 recordsLinked to original sources
PubMed1992

Optimizing primary treatment for advanced laryngeal and pyriform sinus carcinoma.

Advocates of chemotherapy plus radiation as the definitive treatment for patients with advanced laryngeal cancer often cite older studies that attribute cure rates of less than 50% to laryngectomy plus radiation. The outcomes of patients with stage III and IV laryngeal and pyriform sinus carcinoma from 1980 to 1989 (96 patients) were compared with those of patients treated from 1962 to 1977 (84 patients). Demographics, the extent of disease, and nodal involvement were similar between the groups. There were more operative complications (45% versus 22%; p < 0.01) and deaths (10% versus 2%; p < 0.01) in the patients who underwent irradiation preoperatively. Overall survival was improved in the recent group compared with the early group (73% versus 54% at 5 years; p < 0.03), as was disease-free survival (64% versus 38% at 5 years; p < 0.02). Results of treatment for advanced laryngeal and pyriform sinus carcinoma have improved significantly. These modern results should be used to evaluate newer treatment modalities.

Combined Modality Therapy↗
PubMed1992

Developing concepts and treatment of complex maxillary fractures.

The last decade has witnessed a tremendous evolution in the management of maxillary fractures--an evolution that mirrors an overall more aggressive contemporary approach to complex maxillofacial trauma. This article briefly reviews past contributions to the current management of these fractures, the author's approach to management, and the future of this continually improving field.

Bone Transplantation↗
PubMed1991

Split-thickness skin grafting of the myelomeningocele defect: a subset at risk for late ulceration.

The appropriate method and timing of the management of the myelomeningocele defect have prompted considerable discussion. Use of split-thickness skin grafts acutely has accomplished wound closure with low morbidity and mortality. This study was designed to address the question of long-term suitability of the technique of split-thickness skin grafting of the myelomeningocele patient. The incidence of late and/or severe skin ulceration and the presence of gibbus deformity were correlated with the method of skin closure. Long-term follow-up revealed a higher incidence of chronic skin ulceration in the split-thickness skin graft group as compared with the primary closure group. All skin breakdowns appeared in the presence of a gibbus deformity, and gibbus deformity was more prevalent in the split-thickness skin graft group. The incidence of skin ulceration and gibbus deformity was site-dependent. A thoracic or thoracolumbar myelomeningocele repair with split-thickness skin graft was significantly more likely to be complicated by skin problems than the defect in the lumbar, lumbosacral, or sacral region. This relationship was secondary to the frequency of gibbus deformity in the more cephalad defects than defects caudad. A treatment plan is outlined that is based on the primary variable of the location of the myelomeningocele and secondarily by defect size.

Chronic Disease↗
PubMed1991

Reconstruction of the lower lip and chin with the composite radial forearm-palmaris longus free flap.

Four cases of total lip and chin reconstruction are presented. In three, the composite radial forearm-palmaris longus free flap was used for reconstruction. In the fourth case, the palmaris longus was separated from the flap but still used as a lower lip sling. In all cases, the entire lower lip and the soft tissue of the chin were reconstructed in one stage. All patients healed primarily, and the three who underwent radiotherapy tolerated it without complications. Lip seal and speech were good, and there was no problem with drooling. Postoperative results emphasize the importance of respecting the aesthetic unit of the lower lip and chin.

Adult↗
PubMed1990

Maxillofacial trauma.

If a multiply injured patient with severe head injuries, intra-abdominal and intrathoracic injuries is admitted, the diagnosis and management of the facial fractures may be shunted into the background. With the tremendous methods of modern medicine at hand, we are adequately able to resuscitate, treat, and discharge those patients. If the maxillofacial injuries go undiagnosed or untreated, the patient is left with some fairly significant sequelae in function and appearance that are difficult to treat on a delayed basis. Initial management of those injuries can be done concomitantly with management of the other serious life-threatening injuries and a successful outcome achieved. The traditional approach of waiting "until all the swelling goes down" before definitive correction of bony or soft tissue problems are addressed, has been shown to produce inadequate and disabling results both from a structural and functional viewpoint. Following the first or at most second week after injury, the process of bone healing and scar formation have usually progressed quite quickly. This is especially true in children who normally have a very high metabolic rate. A displaced facial fracture not corrected during the initial "golden" period will require major manipulation and even refracture in order to adequately reduce the segments into the proper position and a less satisfactory result than acute management. Similar considerations with respect to the skin and soft tissues are also important. Once scar tissue has formed it becomes very difficult to restore normal or near-normal appearance.(ABSTRACT TRUNCATED AT 250 WORDS)

Humans↗
PubMed1989

Failure of pentoxifylline to enhance skin flap survival in the rat.

The effect of pentoxifylline, a hemorheological agent that increases erythrocyte flexibility and augments capillary blood flow, on the survival of the dorsal skin flap of the rat was studied. An experimental group received intraperitoneal injections of pentoxifylline twice daily, 50 mg/kg/day, and a control group was given identical volumes of saline. Standard McFarlane flaps sized 4 x 9 cm (n = 22) and narrower 2 x 6-cm flaps (n = 18) were constructed 14 days later. After a postoperative observation period of 7 days, no significant difference in tissue survival between the pentoxifylline-treated animals and the controls was found in either flap model. Fourteen days preoperative treatment with pentoxifylline appeared to have no effect on flap survival.

Animals↗
PubMed1988

The use of maggots in wound debridement.

Since antiquity, clinicians have observed that maggots can provide debridement of necrotic wounds, but the therapeutic use has declined since the advent of aseptic wound management and antibiotics. In certain difficult wounds, the use of maggots for debridement may have a role. If so, the larvae must be prepared prospectively to control the bacterial population of the insect's intestinal tract and integument. The mechanism of wound debridement by maggots includes the secretion of proteolytic enzymes and antibacterial substances. A case of infestation of a necrotic wound in a patient with cancer of the head and neck is presented including the entomological identification and description of the maggots.

Animals↗
PubMed1987

Frontal sinus fractures: guidelines to management.

The appropriate management of frontal sinus fractures is controversial. Experience with 78 frontal sinus fractures over a 9-year period was reviewed, and the fractures were classified into anterior wall, anterobasilar, and frontal skull fracture extensions. The presence of a concomitant CSF leak or an air-fluid level in the sinus was a diagnostic clue of posterior wall involvement. Ablation or obliteration of the fractured frontal sinus is not necessary. Primary reconstruction of the sinus and nasofrontal duct drainage constitute the preferred treatment. "Cranialization" of a severely damaged sinus is performed by excision of the posterior wall plugging of the nasofrontal duct and reconstruction of the anterior wall. Reconstruction of the anterior wall with primary bone grafting may be necessary in selected patients.

Accidents, Occupational↗
PubMed1986

Carcinoma of the lower lip.

Carcinoma of the lower lip is sufficiently common in occurrence that a practitioner should be cognizant of the requisite diagnostic and therapeutic guidelines. This article discusses the pertinent anatomy, the management of the local or primary lesion, and some prognostic criteria for surgical decisions directed toward the regional lymph nodes. Reconstruction is discussed from the standpoint of magnitude of the defect as a percentage of the total lip transverse diameter.

Carcinoma↗
PubMed1985

Wound closure of the myelomeningocoele defect.

Our experience with 74 neonates with myelomeningocoele is reported. Management in the first phase of the study period consisted of primary closure in 37 patients by wide undermining and skin advancement, marked by a high wound-complication rate. Latissimus dorsi muscle closure, either "reverse" or advanced, was performed in a transitional phase in 5 patients, characterized by increased operative time and blood loss. In the last portion of the study period, 32 patients were managed by immediate dural closure and skin grafts either simultaneously or on a delayed basis at 48 to 72 hours with a low incidence of graft loss, CSF leak, or sepsis. Back ulceration and follow-up in either the primary closure or the skin-grafted group has been infrequent.

Female↗
PubMed1979

Review of 1,000 major facial fractures and associated injuries.

The records of 1,020 major facial fractures were reviewed, and it was found that the occurrence of life-threatening associated injuries was highly predictable on the basis of the pattern of facial fractures and the circumstances of the injury. Certain groups of patients have a high probability of associated serious injuries of the central nervous system, the trunk, or the extremities. Probably these patients should be primarily under the care of a surgeon who is capable of the diagnosis and emergency therapy of these associated injuries, as well as the facial injuries, so that appropriate priorities can be established and put in effect.

Abdominal Injuries↗
PubMed1978

Shotgun injuries of the upper extremity.

Although most reports of civilian gunshot injuries consist mainly of wounds inflicted by handguns, shotgun wounds deserve special consideration. Longrange shotgun wounds rarely pose a problem; however, medium- and close range wounds of the penetrating and perforating type may inflict substantial soft-tissue loss, bone defects and comminution, and loss of nerve and vessel continuity. Because of the complex and multiple system involvement by shotgun wounds, a greater challenge exists to obtain a successful, functional result. The challenge is most appropriately met by an aggressive approach of early operative exploration and debridement of the wound, internal stablization of the bony fragments, vascular repair when indicated, and exploration and identification of nerve deficits, followed by an early wound closure.

Adolescent↗
PubMed1978

Massive skin necrosis in Rocky Mountain spotted fever.

The occurrence of massive skin necrosis of approximately 50% of the body surface area in an 8-year-old girl with Rocky Mountain spotted fever is reported. Although the surgeon will not often be confronted with the management of Rocky Mountain spotted fever or its complications, certain therapeutic corollaries can be outlined, based upon the observed similarity between this particular complication of severe skin loss and the syndrome of purpura fulminans: (1) heparinization for the consumptive coagulopathy and disseminated intravascular clotting; (2) correction of hypovolemia and hypoproteinemia; (3) decompression by escharotomy and/or fasciotomy if indicated; (4) topical chemotherapeutic coverage of necrotic skin; (5) full-thickness eschar excision combined with biologic dressings directed toward autograft wound closure; and (6) appropriate extremity splinting and physiotherapy.

Child↗