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Biomedical subjects

E A HARRIS

Publications and source records attributed to E A HARRIS.

At least 19 recordsLinked to original sources
PubMed1964

THE RESPIRATORY ACTION OF DICHLORPHENAMIDE.

The action of dichlorphenamide has been investigated in three healthy subjects. After this drug had been given, ventilation increased while alveolar and oxygenated mixed venous Pco(2) both fell. The magnitude of these changes was closely related to the degree of acidosis produced by the drug. The effect of intravenous acetazolamide, tested in one subject, was qualitatively similar to that of orally administered dichlorphenamide. Respiratory responses to carbon dioxide were studied in two of the subjects and in one of them the metabolic acidosis was sufficient to account for the short-term effect of dichlorphenamide on respiration.

Acetazolamide↗
PubMed1963

SCREENING.

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Humans↗
PubMed1963

FIBRINOLYSIS.

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Fibrinolysis↗
PubMed1963

POP "POT".

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Humans↗
PubMed1963

Ventilatory effects of prethcamide in healthy young men.

The ventilatory effects of intravenous injections and infusions of prethcamide have been investigated with healthy young adult male volunteers. Ventilatory changes due to the drug were measured at constant inspired Pco(2) or constant alveolar Pco(2), and in relation to the response to changes in alveolar Pco(2). The experiments show that the drug is a mild and somewhat inconstant respiratory stimulant, slow and prolonged in action and liable to give rise to a variety of unpleasant side-effects.

Adult↗
PubMed1962

Effect of ethamivan (vanillic acid diethylamide) on the respiratory response of healthy young men to carbon dioxide, in the absence of hypoxia.

The effect of ethamivan (vanillic acid diethylamide) on the ventilatory response to carbon dioxide has been investigated in healthy young adult males. Intravenous infusion of the drug at a rate of 9 mg/min causes respiratory stimulation depending in degree upon the prevailing alveolar CO(2) tension. When the latter is low stimulation by the drug is most marked and may largely support respiration below the CO(2) threshold. As alveolar Pco(2) increases, the effect of the drug disappears. These findings are discussed.

Adult↗