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Biomedical subjects

E A Gehan

Publications and source records attributed to E A Gehan.

151 records · Page 9Linked to original sources
PubMedDate not supplied

Early history of pathology studies by the Intergroup Rhabdomyosarcoma Study Group.

This review chronicles the series of publications that were the result of the willingness of pathologists and clinicians in the United States to share their pathologic materials and clinical data on patients who were placed on treatment protocols for rhabdomyosarcoma and related tumors over an extended period of time. The availability of this database enabled pathologists and clinicians to study a tumor type that is rare in individual institutions, but occurs in large enough numbers to produce valid conclusions not otherwise possible. Furthermore, young investigators were challenged by this opportunity and were able to spend the necessary time to make new observations that, in retrospect, helped direct protocol designs that produced significant improvement in patient survival. The key factor in this process is the surrender of individual scientific prerogatives to a small number of investigators. It is also important to recognize that the pathologist component of these series of contributions is only a part of the entire effort. It takes an organization of gifted, dedicated experts in many disciplines working together. The investigators who served on the Intergroup Rhabdomyosarcoma Group over a 25-year period eminently fulfilled this.

Child↗
PubMedDate not supplied

Use of prognostic factors in analysis of historical control studies.

This paper considers the use of regression methods for the interpretation of comparative results between treatments in historical control studies. A logistic regression model is used for response rate studies and Cox's regression model for studies of disease-free or overall survival. For both models, stepwise regression procedures may be utilized to test for treatment differences adjusting for differences in patient characteristics between the treatment groups. Examples are given from two clinical studies: the first example concerned a study which compared disease-free and overall survival experience between patients receiving surgery plus radiation therapy plus FAC-BCG (5-fluorouracil, Adriamycin, and cyclophosphamide-bacillus Calmette-Guérin) as adjuvant treatment compared with surgery plus radiation therapy alone for patients with stage II or III breast cancer; the second example concerned a study of acute leukemia in which differences among complete remission rats by institution were interpreted using a logistic regression equation to adjust for prognostic factors.

Antineoplastic Agents↗