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Biomedical subjects

E A Edwards

Publications and source records attributed to E A Edwards.

At least 73 records · Page 4Linked to original sources
PubMed1975

Epidemiologic survey of rubella in a military recruit population.

A seroepidemiologic surveillance of rubella infections in arriving male and female Navy recruits indicated that from 82-90% of young adults have hemagglutination (HA) titers of 1:10 or greater. Subsequent to the establishment of a new male recruit camp, there was a 10- to 11-month hiatus of low level rubella infection in the population. Once endemic rubella was established, more than 73.3 per cent of those with no detectable initial titer seroconverted. There was no reported rubella infection at an isolated female recruit camp of about 500 women even though the proportion of susceptibles was similar. However, once the female recruit camp was relocated within the male camp, their experience with rubella became comparable. A small (6.8% men, 5.6% women) number of recruits with pre-existing HA antibody titers had a four-fold or greater rise in titer during training. The great transmissibility of rubella virus in a closed population was illustrated and the ineffectiveness of herd immunity in this setting was evident.

Female↗
PubMed1975

Detection of adenovirus in patient specimens by indirect immune electron microscopy.

Immune electron microscopic procedures for the detection of adenovirus type 7 directly in throat swab specimens from patients are described. Nineteen of 25 throat swab samples, known to be positive for adenovirus type 7 by isolation of virus from tissue culture, were shown to contain aggregates of adenovirions coated with antibody. Sensitivity tests of the immune electron microscopic method showed that as few as 16 to 32 tissue culture infective doses of virus could be detected by the direct immune electron microscopic technique. It was also demonstrated that aggregation of virus-antibody complexes could be further enhanced by use of anti-immunoglobulin G sera (indirect immune electron microscopic procedures). These results demonstrate that examination of patient specimen by immune electron microscopic procedures is a feasible and rapid method for adenovirus detection and suggest that it could be applied as a routine laboratory procedure for the diagnosis of other virus infections.

Adenoviridae↗
PubMed1974

New method of grouping beta-hemolytic streptococci directly on sheep blood agar plates by coagglutination of specifically sensitized protein A-containing staphylococci.

A technique is described that allows the grouping of beta-hemolytic streptococci directly upon the primary colony. This was accomplished by applying a small drop of specifically sensitized protein A-containing Staphylococcus aureus over a colony of streptococci, rocking the plate to allow mixing of the particles with the soluble group-specific polysaccharide, which in the case of beta-hemolytic streptocicci was produced in abundance during colony formation, and observing for agglutination of the sensitized particles. Such a simple test for group A beta-hemolytic streptococci should allow accurate identification of group A streptococci in small laboratories, such as in clinics or physicians' offices, as well as in the larger public health and private laboratories.

Agar↗
PubMed1974

Reactions and serologic responses to monovalent acetone-inactivated typhoid vaccine and heat-killed TAB when given by jet injection.

Monovalent acetone-inactivated typhoid vaccine and heat-killed TAB caused local reactions in 82-88% of volunteers vaccinated by jet injection, whereas they caused local reactions in only 24% of volunteers injected by means of a conventional syringe. Both vaccines induced a high seroconversion rate to typhoid H antigen, but neither proved significantly immunogenic to antigens O and Vi. There was no increase in the occurrence of local reactions when a second jet injection was given 5 weeks after the first.

Adult↗
PubMed1973

Extreme old age.

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Aged↗
PubMed1973

Serological grouping of hemolytic streptococci by counter-immunoelectrophoresis.

The counter-immunoelectrophoresis (CIE) method of grouping streptococci was more sensitive than the capillary precipitin method. The precipitate was easier to read, and the test was simple to perform and required fewer reagents. An autoclave-Pronase-B extraction procedure is described and was found superior to either acid, Pronase-B, or the autoclave extraction procedures for recovering groupable polysaccharide from different strains of streptococcal groups A, B, C, D, F, and E. Data obtained from over 400 strains indicate that the sensitivity of the CIE and a more efficient extraction of groupable polysaccharide provides a simple method for rapid diagnosis of streptococcal infections.

Evaluation Studies as Topic↗