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Biomedical subjects

E A Danilova

Publications and source records attributed to E A Danilova.

10 recordsLinked to original sources

Thiadiazole-derived expanded heteroazaporphyrinoids.

[structure: see text] Heteroannulenes 1 and 3 containing three subunits of isoindole or pyrrole, respectively, three 1,3,4-thiadiazole moieties, and six aza-bridges have been synthesized by reaction of the corresponding diiminoisoindoline or diiminopyrroline with 2,5-diamino-1,3,4-thiadiazole. These conjugated nonaromatic 30 pi-electron macrocycles coordinate three metal ions within their central cavity and constitute one of the rare examples of expanded heteroazaporphyrinoids.

Journal Article↗

Mapping of ecologically unfavorable territories based on human hair composition.

As was shown (1), analysis of human hair on the population level and mapping of large territories using hair elemental composition are promising approaches for estimation of both the environmental situation and the population health status. In (1,2) the map of Uzbekistan (sampling in 1981) was discussed. Ten years later (1991), samples from the territory in the vicinity of the drying out Aral Sea were taken again. Samples were analyzed for 24 elements using instrumental neutron activation analysis. Comparison of the data and maps drawn for 1981 and 1991 and their comparison with changes of the health status have shown that repeated mapping of territories using data on human hair elemental composition could be used in medical geography, especially for prediction of health status changes in ecologically unfavorable areas.

Environmental Pollutants↗

Mapping using human blood composition data.

The mapping of elemental composition using INAA on the base of whole blood and hair of inhabitants (2500 samples) was made in Uzbekistan (CIS). The average concentrations of 15 elements (24 for hair) were determined. The results obtained were compared to regional medical statistics. The correlations for various diseases were obtained. The maps of human blood composition in comparison to those for human hair composition seem to be less significant in terms of regional contamination (probably because of stronger homeostatic control of blood). On the other hand, specific changes of blood composition were detected for some occupational groups. Relationships of blood and hair elemental composition and their relative significance are discussed.

Blood Chemical Analysis↗

[The role of echography and hysteroscopy in detection of the causes of uterine hemorrhage in the postmenopausal period].

Forty-six patients with bloody discharge in the postmenopausal period were examined by echography and hysteroscopy, and the data of these techniques were compared with the results of endometrial curettage. The results evidence that echography is a valuable diagnostic method that permits the detection of or ruling out the hyperplastic processes of the endometrium in the postmenopausal period. Diagnostic curettage of the uterine cavity, monitored by hysteroscopy, improves the accuracy of the diagnosis of causes of hemorrhages in the postmenopausal period, for it helps purposefully remove the involved sites of the endometrium.

Aged↗

[Quantitative characteristics of the immunocompetent cells of the large-intestinal mucosa in acute dysentery].

Histological and immuno-morphological examinations of the large intestine mucosa obtained by aspirational biopsy from 38 adult patients with acute dysentery in the mild, moderately severe and severe forms and from 4 normal subjects were carried out. In each case, a per cent ratio of immunocompetent cells in deep and superficial parts of the mucous membrane proper, the content of interepithelial lymphocytes, the cell density of infiltrate per 1 mm2 of the mucous membrane, the number of cells producing IgA, IgM, and IgG per 1 mm2 of the mucous membrane were determined. As the severity of clinical and morphological manifestations of dysentery increased, the number of cells actively producing immunoglobulins was found to increase and epithelium infiltration with lymphocyte to be enhanced. The main role in the development of local immune response in dysentery is played by IgA-producing cells, and in the moderately severe and severe forms of dysentery the number of IgM-producing cells increases.

Adult↗