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Biomedical subjects

E A Benson

Publications and source records attributed to E A Benson.

At least 55 records · Page 3Linked to original sources
PubMed1987

Short term morbidity and cosmesis following lumpectomy and radical radiotherapy for operable breast cancer.

One hundred and eighty-four patients with T0-T2, N0-N1b, M0 breast cancer were treated by local excision and radical radiotherapy. Short-term morbidity and cosmetic assessment are reported after a median follow-up of 21 months. At 1 year 80% of women considered the cosmetic result very good or excellent, whereas only 63% of their consultants gave a similar assessment. Mild or moderate arm oedema developed in 22% of patients, radiation pneumonitis in 9% and oesophagitis in 11%. Mild discomfort in the treated breast was reported by 39% and moderate by 17%. Oedema of the breast was noted in 20%. It is too early to comment on long term disease control or final cosmetic result but to date the morbidity has been considered acceptable and measures to reduce it further are being implemented.

Adult↗
PubMed1986

The effect of surgical technique on local recurrence rates following mastectomy.

The effects of two different axillary techniques, i.e. sampling and dissection, in combination with mastectomy for operable carcinoma are compared. The dissection technique when combined with radiotherapy gives better local disease control than sampling. This also confirms the proposition that an axillary sampling technique is an inefficient method of staging breast cancer and its use will result in inferior local disease control.

Breast Neoplasms↗
PubMed1985

Long-term metabolic control with insulin pump therapy. Report of experience with 127 patients.

To determine the long-term efficacy of insulin-pump therapy, we analyzed trends in glycosylated hemoglobin concentrations in 127 patients with Type I diabetes using insulin pumps for periods ranging from 13 to 47 months. In the first year of pump therapy the average glycosylated hemoglobin concentration improved in 83 per cent of the patients, as compared with the value before pump therapy. Although only 11 of the 127 subjects had normal glycosylated hemoglobin values before pump therapy, 33 had a normal average value during the first full year of pump use (P = 0.0001). This favorable trend persisted for the three-year duration of the study. Seventeen of the 19 patients who subsequently discontinued insulin-pump therapy had improved glycosylated hemoglobin values during the period of pump use. Eleven of the 19 patients remained available for follow-up study; the glycosylated hemoglobin concentration became worse in 7 when they returned to conventional treatment. We conclude that the improvement in metabolic control repeatedly demonstrated in short-term studies with the insulin pump can be maintained for a period of years.

Adult↗
PubMed1985

Blood group as a prognostic indicator in breast cancer.

A retrospective analysis of 1001 patients with invasive breast cancer showed a difference in survival between patients with different blood groups. Analysis of time from operation to local recurrence and to general recurrence reinforced this finding. The difference between blood groups became increasingly significant after accepted prognostic factors were allowed for. Patients at particularly high risk of early death or general recurrence were those with blood groups B and AB, those with group AB having a greater relative local recurrence rate.

ABO Blood-Group System↗
PubMed1985

Insulin antibodies in patients receiving penicillamine.

In a patient receiving penicillamine for treatment of rheumatoid arthritis, antibodies to insulin developed, which resulted in symptomatic hypoglycemia. When 30 additional patients receiving penicillamine were screened, another patient was discovered to have antibodies to insulin. The level of antibody fell sharply in both patients after penicillamine was discontinued. This particular immunologic reaction to penicillamine has not been reported previously.

Adult↗
PubMed1985

Triorchidism.

Triorchidism is a rare congenital abnormality in which there are three testes. Approximately 70 cases have been reported in which histological examination has confirmed the diagnosis. This is a report of a further case of triorchidism in a 12-year-old boy. Some interesting features of previous cases are summarized, and the possible anatomical variations of testes, epididymis and vas are outlined.

Child↗
PubMed1984

Acute complications associated with insulin infusion pump therapy. Report of experience with 161 patients.

We determined the frequency of acute complications associated with insulin pump therapy in 161 insulin-dependent patients followed up for a total of 2,978 patient-months. Diabetes control improved substantively with pump therapy, but 42% of the patients experienced one or more acute complications while using insulin pumps. Infected infusion sites, ketoacidosis, and hypoglycemic coma occurred once in every 27, 78, and 175 patient-months, respectively. More patients experienced ketoacidosis after the onset of pump therapy than in an equivalent interval immediately before the onset of pump therapy. Ketoacidosis also occurred in more patients using pump therapy than in a comparison group of 165 patients receiving conventional insulin injections surveyed during an equivalent period. The frequency of hypoglycemic coma was not significantly changed by pump therapy.

Acute Disease↗
PubMed1984

Insulin autoimmunity as a cause of hypoglycemia.

"Autoimmune" hypoglycemia is a syndrome consisting of fasting hypoglycemia, hyperinsulinemia, and insulin-binding antibodies in a patient who has never been exposed to exogenous insulin. The stimulus for insulin-antibody formation and the mechanism of the hypoglycemia in this condition remain unknown. Three patients with this rare syndrome had severe hypoglycemia of limited duration. Two had received a drug containing a sulfhydryl group (methimazole and penicillamine) as treatment for an autoimmune disorder (Graves' disease and rheumatoid arthritis, respectively). A third patient who underwent surgery for a suspected insulinoma was found to have pancreatic beta cell hyperplasia. Drugs containing a sulfhydryl group may have a role in the etiology of the syndrome. Additionally, our findings suggest a relationship between circulating insulin antibodies and beta cell hyperplasia.

Autoantibodies↗
PubMed1984

Operations upon the biliary tract in patients with acute pancreatitis: aims, indications and timing.

The management of gallstones in patients with acute pancreatitis (AP) is controversial. This paper reports an analysis of 171 attacks of AP associated with gallstones. Whilst awaiting elective cholecystectomy 56% of patients had further symptoms and 1 died. Non-urgent operations during the same admission as the pancreatitis (n = 34) resulted in 2 deaths and 7 septic complications, but prediction of complications may be possible. Urgent surgery (n = 5) was followed by 3 deaths. This study suggests that in most patients, cholecystectomy should be performed as soon as the patient is adequately fit. Urgent removal of an impacted ampullary stone (preferably by endoscopic papillotomy) may be required in a small minority if severe pancreatitis fails to respond to medical treatment, or if cholangitis supervenes .

Acute Disease↗
PubMed1982

Evidence for independent regulation of human erythrocyte and adipocyte insulin receptors.

Specific binding of [125I]-insulin was measured in erythrocytes and fat obtained at the time of mastectomy in twenty-three subjects. There was a significant negative correlation between the level of specific binding to fat and fasting insulin concentration (r=0.55, p less than 0.05, n=23) suggesting down-regulation of fat insulin level by insulin. Insulin binding to erythrocytes did not correlate with insulin nor was there any relationship between insulin binding to erythrocytes and fat from the same subject. Thus while the erythrocyte insulin receptor may be of interest in its own right, it may not be subject to the normal regulatory influences seen in classical insulin target tissues. Insulin binding to erythrocytes may therefore be invalid as a model to study down-regulation of insulin receptors.

Adipose Tissue↗