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Biomedical subjects

E A Balazs

Publications and source records attributed to E A Balazs.

At least 37 records · Page 2Linked to original sources
PubMed1980

Cytological studies on the developing vitreous as related to the hyaloid vessel system.

The embryonic development of the cell population of the mammalian vitreous has been traced to two sources: the undifferentiated mesenchymal cells of the eye primordium and the primitive reticular cells of the bone marrow. Undifferentiated mesenchymal cells invade the future vitreous space in two ways: through the annular opening between the rim of the optic cup and the lens primordium, and through the open embryonic fissure. They differentiate into prevascular cells, hemangioblasts, and fibrocytes located in the area of the optic nerve head. From the very beginning of fetal development, another ameboid-type cell of mesenchymal origin makes its entrance into the vitreous through the hyaloid vessels; these monocyte-like cells differentiate into hyalocytes and populate a well-defined area of the cortical vitreous close to the retina and to the ora serrata. Gamma-irradiation (600 rads) of newly born rabbits and cats decreases the number of migrating amebocytes in their vitreous; 24 h later, however, they are replaced by monocytes from the hyaloid vessels.

Animals↗
PubMed1980

The use of sodium hyaluronate (Healon) in human anterior segment surgery.

The safety and efficacy of sodium hyaluronate (Healon) was evaluated in a wide spectrum of anterior segment surgical procedures. Healon is not only safe, but actually facilitates the outcome of surgery. Healon placed intracamerally before cataract removal results in significantly decreased endothelial cell loss. In filtering procedures, use of intracameral and subconjunctival Healon promotes superior bleb formation while still maintaining chamber depth postoperatively. Corneal grafts performed over intracameral Healon receive maximal endothelial protection and manifest striking postoperative clarity.

Anterior Chamber↗
PubMed1980

Inhibition of phagocytosis by high molecular weight hyaluronate.

The effect of sodium hyaluronate on phagocytosis was studied using a sensitive polystyrene latex sphere assay in mouse peritoneal macrophage monolayers. Viscous solutions of high molecular weight hyaluronate (4.6 X 10(5)--2.8 X 10(6)) caused a dose-dependent inhibition of phagocytosis, but low molecular weight hyaluronate (9.0 X 10(4)) was not inhibitory at equivalent viscosity. The inhibitory effect of high molecular weight hyaluronate did not appear to be mediated by the polyanionic charge of the molecule since sulphated glycosaminoglycans with greater charge density (heparin and chondroitin sulphate) were ineffective. In addition, competitive inhibition studies indicated that a direct effect on possible cell surface membrane receptors was unlikely. Instead, physical factors such as steric hindrance by the continuous polymeric network, were considered of more importance. Alternatively, the hydrophilic polysaccharide may have inhibited phagocytosis by providing an unsuitable surface for adhesive contact between the latex beads and the cell surface.

Animals↗