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Biomedical subjects

E A Alekseev

Publications and source records attributed to E A Alekseev.

10 recordsLinked to original sources
PubMed1999

[Effect of gravitation loading and retabolil on development of atrophy in muscles and bones of rats due to suspension].

In a 3-wk experiment with tail-suspended rats histological and histomorphometric methods were used to determine the effects of graded gravitational loading (GGL) and anabolic steroid retabolil (nortestosterone decanoate) on the course of atrophy in soleus m. (SM), gastrocnemius m. (GM), tibia and humerus, and functioning of somatotrophic hormones (STH) of the pituitary and thyrocytes of the thyroid. Suspension was found to produce atrophy in SM and, to a less degree, in GM, partial transformation of SM slow fibers into the fast ones, suppression of the tibial longitudinal growth, demineralization of the tibial and humeral spongious metaphyses; besides, functional activities of STH-cells and thyrocytes were inhibited. Graded gravitational loading of rats by intermittence of suspension for 2 hrs slowed down atrophy in both muscles and osteopenia in tibia, stimulated the synthetic and secretory functions of STH-cells without any marked effect on thyrocytes or humeral osteopenia. GGL failed to influence the slow-to-fast transformation of SM fibers. Two injections of retabolil at the total dose of 3 mg/kg of the body mass somewhat interfered with the SM atrophy and humoral osteopenia, and were favorable to the synthetic but not secretory activity of STH-cells. Neither SM and tibial atrophies nor thyroid activity of the gland were improved. The prophylactic action of GGL upon the SM and humeral atrophies was significantly higher when combined with retabolil, whereas GM and tibia were not noticeably cured by retabolil. Inhibition of the SM atrophy and humeral osteopenia in rats treated with GGL and retabolil concurred with elevated activities of STH-cells and thyrocytes indirectly suggesting their more intensive production of the growth hormone and thyroid hormones, respectively.

Anabolic Agents↗
PubMed1989

[Birth injuries of the spine].

Results of treatment of 204 children with labour traumas of the vertebral column are presented. Among the 204 patients there were 151 neonates, 28 infants and 25 patients with consequences of labour trauma. The cervical part is traumatized most frequently. Injury of the cervical vertebrae was diagnozed in 154 patients, of lumbar vertebrae in 18 patients. One child has an injury of the cervical and thoracic vertebra. In 41 patients there were ischemias in the vertebrobasilar area. An associated labour trauma of the vertebral column was diagnozed in 36% of the cases. Results of treatment were followed-up in 174 patients. Good results were obtained in 133 patients (76%). Satisfactory results were noted in 36 children (20%). Five patients died. Early and complex treatment gave good results in 93% of the cases.

Birth Injuries↗
PubMed1985

[Possibility of predicting and preventing postoperative complications leading to relaparotomy].

The occurrence of relaparotomies is known to be 1,2% of operations on the abdomen organs. Pyo-inflammatory complications are responsible for more than half cases resulting in relaparotomies. Relaparotomies are divided into emergent and urgent, radical and palliative. A system for prognosis of complications and differential diagnosis of postoperative paresis of the gastro-intestinal tract and postoperative peritonitis is presented. Prophylactics of postoperative complications reduced lethality after relaparotomies from 79% to 56%.

Electrodiagnosis↗
PubMedDate not supplied

[Evaluation of the action of ivermectin on blood-sucking mosquitoes].

The effect of Ivomec, a formulation of ivermectin administered by various routes: through biological membrane and feeder animal was assessed. Higher insecticidal effect was obtained by feeding mosquitoes with blood containing ivermectin through biological membrane. Anopheles stephensi females were the most sensitive of 3 species under study. Their total death after feeding was observed at 1 ppm, while for Aedes aegypti the lethal dose was 2.5 ppm and for An. sacharovi, 50 ppm. Subcutaneous injection of the drug to rabbits at the dose 0.34 mg/kg wt with further feeding on it of 3 Anopheles species demonstrated the highest drug sensitivity of An. stephensi mosquitoes. Death rates among the females fed on the rabbit 4-6 days after injection of the drug were 93, 70 and 79%, respectively. Death rates among An. sacharovi and An. atroparvus differed only slightly from that of the control group. In some experiments ivermectin effect on female fertility and larvae hatching from ova can be traced. Probably, increasing the preparation dose, administered to an animal-feeder, may change significantly characteristics of the malaria carrier natural population. Moreover, further use of ivermectin versus helminths and mosquitoes in zootechnical practice may produce a side-effect on mosquitoes, feeding recurrently on domestic animals, thus increasing the effect of malaria zoological control.

Animals↗