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Biomedical subjects

Dominik Szczerba

Publications and source records attributed to Dominik Szczerba.

2 recordsLinked to original sources

Simulating vascular systems in arbitrary anatomies.

Better physiological understanding of principles regulating vascular formation and growth is mandatory to their efficient modeling for the purpose of physiologically oriented medical applications like training simulation or pre-operative planning. We have already reported on the implementation of a visually oriented modeling framework allowing to study various physiological aspects of the vascular systems on a macroscopic scale. In this work we describe our progress in this field including (i) extension of the presented model to three dimensions, (ii) addition of established mathematical approaches to modeling angiogenesis and (iii) embedding the structures in arbitrary anatomical elements represented by finite element meshes.

Animals↗

Computational model of flow-tissue interactions in intussusceptive angiogenesis.

Angiogenesis, the growth of vascular structures, is a complex biological process which has long puzzled scientists. Better physiological understanding of this phenomenon could result in many useful medical applications such as the development of new methods for cancer therapy. We report on the development of a simple computational model of micro-vascular structure formation in intussusceptive angiogenesis observed in vivo. The tissue is represented by a discrete set of basic structural entities and flow conditions within the resulting domain are obtained by solving the Navier-Stokes equations. The tissue is then remodelled according to the tangential shear stress while approximating advection by means of simple non-diffusive heuristics. The updated tissue geometry then becomes the input for the next remodelling step. The model, consisting of steady-state flow and a simple mechanistic tissue response, successfully predicts bifurcation formation and micro-vessel separation in a porous cellular medium. This opens new modelling possibilities in computational studies of the cellular transport involved in micro-vascular growth.

Capillaries↗