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Dion Paridaens

Publications and source records attributed to Dion Paridaens.

11 recordsLinked to original sources
PubMed2006

Acquired capillary hemangioma in the lacrimal sac region.

PURPOSE: To describe two cases of acquired capillary hemangiomas in adults, in the lacrimal sac region. DESIGN: Interventional case reports. METHODS: Review of the history, clinical examination, and pathologic findings. RESULTS: Two patients, an 80-year-old woman and a 50-year-old man, presented with a history of tearing and a slowly growing nodular mass in the lacrimal sac area. Probing and irrigation showed a patent drainage system in both cases. Both lesions were biopsied. Histopathologic examination of the specimens showed capillary hemangiomas. CONCLUSIONS: Capillary hemangiomas in the lacrimal sac area may present with clinical features of more common lesions such as dacryocystitis or mucocele, or rarer lacrimal sac malignancies. They should therefore be considered in the differential diagnosis of any nodular lesion in this area in adults, even at a very late age.

Aged, 80 and over↗
PubMed2006

Fronto-ethmoidal mucocele after coronal orbital decompression.

A patient who underwent coronal orbital decompression for Graves' orbitopathy eight years earlier presented with left-sided proptosis without signs of periorbital inflammation. Computed tomography imaging showed a fronto-ethmoidal mucocele. It is suggested that this mucocele may be a late complication of decompression surgery.

Decompression, Surgical↗
PubMed2006

Clinical and cytogenetic analyses in uveal melanoma.

PURPOSE: Uveal melanoma is one of the most frequently occurring primary intraocular malignancies in the Western world. Cytogenetically these tumors are characterized by typical chromosomal losses and gains, such as loss of 1p, 3, and 6q and gain of 6p and 8q. Whereas most studies focus on known aberrations, in this one, cytogenetic changes were characterized and correlated with clinical and histopathologic parameters. METHODS: Karyotypes of 74 primary uveal melanomas were analyzed with respect to the presence or absence of chromosomal gains and losses. In the analysis, classic clinical and histopathologic parameters were analyzed together with the chromosomal aberrations. RESULTS: At a median follow-up of 43 months, 34 patients had died or had metastatic disease. Clonal chromosomal abnormalities were present in 59 tumors. The most frequent chromosomal abnormalities involved chromosome 8 (53%); loss of chromosome 3, p-arm (41%) and q-arm (42%); partial loss of chromosome 1, p-arm (24%); and abnormalities in chromosome 6 that resulted in gain of 6p (18%) and/or loss of 6q (28%). Less-frequent aberrations were abnormalities in chromosome 16, in particular loss of chromosome 16 q-arm (16%). In the univariate analysis, loss of chromosome 3, largest tumor diameter, gain in 8q, and mixed/epithelioid cell type in the tumor compared with tumors without these chromosomal changes or with a spindle cell type was associated with decreased disease-free survival. When corrected for confounding variables, significance of gain of 8q and cell type was decreased, whereas the significance of loss of chromosome 3p or 3q and largest tumor diameter remained the same. CONCLUSIONS: Monosomy 3 and largest tumor diameter are the most significant in determining survival of patients with uveal melanoma. Abnormalities in the q-arm of chromosome 16 are relatively common in uveal melanoma, but are not associated with survival or other cytogenetic or histopathologic parameters.

Adult↗
PubMed2005

Blepharoptosis and upper eyelid swelling due to lipogranulomatous inflammation caused by silicone oil.

PURPOSE: Report of two patients who presented with unilateral upper eyelid swelling and ptosis 1 and 8 years, respectively, after vitreoretinal surgery with intraocular silicone oil. DESIGN: Report of two cases. METHODS: In the first case, the oil was still present in the eye. In the second case, the intraocular oil and an epibulbar buckle had been removed 7 years earlier. RESULTS: Histopathology of upper eyelid skin and preaponeurotic fat revealed lipogranulomatous inflammation. CONCLUSIONS: Leakage of intraocular silicone oil into the eyelid tissues may cause an inflammatory reaction resulting in eyelid swelling and ptosis. We presume that in the first patient, silicone oil had leaked from the eye during or after surgery; in the second patient, silicone oil had probably been left behind in the space previously occupied by the epibulbar buckle.

Aged↗
PubMed2005

In situ adenocarcinoma ex pleomorphic adenoma of the lacrimal gland.

A case of an in situ adenocarcinoma of the lacrimal gland that developed in a recurring pleomorphic adenoma is presented. Six years after incomplete resection of a pleomorphic adenoma, the patient complained of a progressive swelling of her right upper eyelid without pain or diplopia. An orbital computerized tomography scan showed an inhomogeneous mass in the right lacrimal gland region without bone involvement. After local excision of the in situ adenocarcinoma ex pleomorphic adenoma, the tumour has been in control for over 6 years.

Adenoma, Pleomorphic↗
PubMed2005

Concurrent loss of chromosome arm 1p and chromosome 3 predicts a decreased disease-free survival in uveal melanoma patients.

PURPOSE: Uveal melanoma is a highly malignant disease with a mortality rate of 50% at 10 to 15 years. Previous studies have shown that chromosomal changes are associated with decreased survival of the patient. However, in these studies the small number of tumors analyzed did not allow robust statistical analysis. In the present study, the independent numerical changes in chromosomes 1, 3, 6, and 8 on disease-free survival (DFS) was assessed in a large series of patients with uveal melanoma. METHODS: One hundred twenty tumors from patients with uveal melanoma were analyzed for numerical changes in chromosomes 1, 3, 6, and 8, with cytogenetic analysis, fluorescent in situ hybridization, and/or comparative genomic hybridization. Data were correlated with disease outcome in univariate and multivariate analyses, by Kaplan-Meier and Cox regression analyses. RESULTS: At a mean follow-up time of 45 months, 42 patients had died or had metastatic disease. In the univariate analysis, loss of chromosome 3, gain of 8q, largest tumor diameter, or the presence of epithelioid cells was associated with a decreased DFS. In the multivariate analysis, the effect of monosomy 3 on survival was largely modified by changes in 1p36. Regarding all chromosomal changes, only the concurrent loss of the short arm of chromosome 1 and all of chromosome 3 was an independent prognostic parameter for disease-free survival (P < 0.001). CONCLUSIONS: In uveal melanoma, concurrent loss of the short arm of chromosome 1 and all of chromosome 3 is an independent predictor of decreased DFS.

Adult↗
PubMed2002

Caruncle tumor as the first sign of metastatic lung carcinoma.

PURPOSE: Report of a neuroendocrine carcinoma of the caruncle as the first sign of a metastatic lung carcinoma. DESIGN: Interventional case report. METHODS: Excision of a rapidly growing caruncular tumor in a 76-year-old woman with a history of breast cancer. RESULTS: Pathology revealed a large cell neuroendocrine carcinoma, consistent with metastatic lung carcinoma. Computerized tomography of chest, abdomen, and a bone scan disclosed signs of malignancy in the lungs, liver, and bones, originally considered as metastatic breast cancer. However, this diagnosis was excluded on the basis of histopathological findings and clonality analysis. A primary neuroendocrine (Merkel cell) carcinoma was ruled out on morphologic and immunohistochemical grounds. CONCLUSION: We present a unique case of a metastatic large cell neuroendocrine carcinoma of the caruncle.

Aged↗