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Biomedical subjects

Dilek Senen

Publications and source records attributed to Dilek Senen.

16 recordsLinked to original sources

Flipper hand.

Explore the source record for details and available documents.

Adult↗

Effects of different vascular patterns and the delay phenomenon on rat ventral island flap viability.

The objective of the current study was to investigate flap viability and to determine optimal delay time by designing various blood flow patterns in the superficial inferior epigastric (SIE) artery (A) and vein (V) flap model. Flaps measuring 7 x 7 cm were created in 42 Sprague-Dawley rats, which were divided into six groups. In group I rats (AV-AV), the flap was elevated based on the bilateral SIE vessels. In group II rats (AV-A), the flap was elevated based on the right SIE vessels and the left artery. In group III rats (V-AV), the flap was elevated based on the left-side vein whereas the SIE artery and vein were the pedicle on the right side. In group IV rats (V-A), the flap was elevated as a venous flap on the left side and was SIE artery based on the right side. In group V rats (AV-) the flap was elevated based on the right SIE artery and vein. In group VI rats (delay), the SIA artery and vein on the left side were ligated without elevation during the first session. The flap was elevated on the right SIE artery and vein 7 days after the delay procedure. Percentages of viable flap surface area were measured in millimeters with acetate paper on day 5 after surgery. The highest viability was seen in group I rats (96.14%), and the delay group had the second highest viable area (88.56%). The area that remained viable in group II was larger than that of group III (87.41% vs. 72.84%; p < 0.05). The least viable areas were observed in group IV. The percentage of viable flap area was significantly higher in the delay group when compared with group V rats (88.56 +/- 1.06% vs. 60.01 2.58%; p < 0.05). In conclusion, if the contralateral pedicle is ligated 7 days before SIE vessel-based island flap elevation, the flap can be used safely in a manner that crosses the median. Artery inflow of the flap is more important than venous outflow for improvement of flap viability on the contralateral side.

Animals↗

Contribution of vitamin C administration for increasing lipolysis.

This experiment was designed to investigate whether addition of vitamin C to the solution used in tumescent technique of liposuction might increase lipolysis and whether increased fibrosis might improve skin retraction where liposuction did not work properly and the skin had poor retraction ability. Eighteen Sprague-Dawley rats were used in two groups. Both inguinal fat pads of rats with their vascular structures were elevated and the right inguinal fat pad was injected with 1 cc tumescent solution as a control and the left fat pad with a 1 cc vitamin C-tumescent solution. Histopathological examination showed that all fat pads injected with tumescent solution had normal adipocytes. Those injected with vitamin C-tumescent were shown to have extreme fibrosis and occasional adipocytes.

Adipose Tissue↗

Cryopreservation of hair follicles at 20 degrees C: can it work in staged hair transplantation.

Androgenic alopecia is a serious problem for a large proportion of the population, especially males, and causes them to seek medical help. Many methods have been described for treatment of androgenic alopesia. Among them are punch grafts, strip grafts, scalp grafts, scalp reductions, tissue expanders, and flap combinations, and hair transplantations with minigrafts and micrografts. The latter has become popular in the last two to three decades and has been investigated extensively. Improvements in hair replacement with minigrafts and micrografts may allow an ideal result with a nearly normal appearance. However, hair replacement with these grafts has important disadvantages. It requires a long operational time and only a limited number of grafts can be placed in one session. In this study, we investigated morphological structures of micrografts stored at 4 degrees C and those stored at -20 degrees C. We found that morphological structures of the grafts stored at 4 degrees C started to be impaired in the fifth day, but that the morphological structures of the grafts stored at -20 degrees C remained unaltered for 15 days. If this method is put into practice, the use of minigrafts and micrografts available will not only obviate the second graft harvesting, but also allow reconstruction of a large area in a short period of time.

Adult↗

The fate of folded and unfolded dermal grafts: a histopathologic and structural study of rabbits.

Currently, both autogenous and nonautogenous materials are used to treat contour deformities. Autogenous grafts are preferable to nonautogenous grafts because they cause less reaction and are both inexpensive and easy to obtain. Currently, however, no consensus exists on an ideal autogenous graft. As autogenous materials, dermal grafts can be obtained from scar tissue, allowing simultaneous revision of scars, quicker vascularization than with other autogenous tissues, and a very short immobilization for their stabilization (i.e., they interact with surrounding tissues). The operation can be performed with the patient under local anesthesia, providing regular contours easily. Alternative techniques are needed to increase the viability and mass effects of autogenous grafts in the long term. With this as the objective, folded dermal grafts were used to increase the mass effects of dermal grafts. The current study compared long-term histopathologic and structural changes in unfolded and folded dermal autogenous grafts used for correction of soft tissue contour deformities. Thicknesses and histopathologic changes of the unfolded and folded dermal autogenous grafts were evaluated 6 and 12 months after placement of the grafts in the abdomens of 10 rabbits. Both the authors' observations and histopathologic examinations showed that the folded dermis caused a more severe granulomatous reaction and fibrosis. Graft thicknesses considerably increased in the first 6 months, but then almost leveled off in the following months. Increased fibrosis in the folded grafts had a masslike effect, which was preserved in the long term, suggesting that folded dermal grafts can be used clinically.

Animals↗

A new method for umbilicus reconstruction: preliminary report.

The umbilicus is a very important component of the abdominal aesthetic view. However, loss of the umbilicus for any reason is a challenging problem. Various methods for umbilicus reconstruction have been published. Most of these methods are complex, and the surgical outcome is mostly unsatisfactory for the patients. The authors have developed a simple method for umbilicus reconstruction using a bilobed flap.

Humans↗

Augmentation mammaplasty: retrospective analysis of 210 cases.

Since its introduction in 1895, augmentation mammaplasty has gained widespread acceptance. The choice of breast augmentation procedure is determined almost entirely by three variables: the selection of incision location, the pocket plane for implant placement (either subpectoral or completely subglandular), and the appropriate implant. The current study evaluated 210 cases of augmentation mammaplasty retrospectively. A capsular contracture rate of 8% was found. Rupture and gel bleeding were observed in eight cases (4%). For various reasons, such as capsular contracture or implant rupture, the prostheses were renewed once in 16 patients (8%) and twice in 5 patients (2%). Submammary incision was used in 42 cases (20%). The patients in 23 cases responded that they had implant folds or edges they could feel (11%). Only 4 of these 23 patients stated that feeling the edge of the implant was a concern for them. Of the 210 augmented breasts, 5 had diminished sensation postoperatively (2%), as interpreted by the patient.

Breast Implantation↗