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Defeng Wang

Publications and source records attributed to Defeng Wang.

3 recordsLinked to original sources

Structured one-class classification.

The one-class classification problem aims to distinguish a target class from outliers. The spherical one-class classifier (SOCC) solves this problem by finding a hypersphere with minimum volume that contains the target data while keeping outlier samples outside. SOCC achieves satisfactory performance only when the target samples have the same distribution tendency in all orientations. Therefore, the performance of the SOCC is limited in the way that many superfluous outliers might be mistakenly enclosed. The authors propose to exploit target data structures obtained via unsupervised methods such as agglomerative hierarchical clustering and use them in calculating a set of hyperellipsoidal separating boundaries. This method is named the structured one-class classifier (TOCC). The optimization problem in TOCC can be formulated as a series of second-order cone programming problems that can be solved with acceptable efficiency by primal-dual interior-point methods. The experimental results on artificially generated data sets and benchmark data sets demonstrate the advantages of TOCC.

Journal Article↗

[The factors influencing metoprolol succinate release from hydroxypropyl methylcellulose matrix tablet].

The hydroxypropyl methylcellulose (HPMC) matrix tablet containing metoprolol succinate (MS) as a model drug was obtained by wet method compression tablet. The effects of the amount and viscosity of HPMC, the preparation method, compressing pressure, the amount of ethycellulose (EC), the pH of dissolution medium and the speed of basket rotation on the drug release from the matrix tablets were evaluated. The results showed that the release rate of metoprolol succinate from HPMC matrix tablets followed Higuchi equation. The release mechanism was in line with the synthetical effect of diffusion and corrosion. Drug release was influenced by the amount and viscosity of HPMC, the amount of EC in matrices, the preparation method and compressing pressure, etc. Drug release was not influenced by the pH of dissolution medium used, and not by the speed of basket rotation, either.

Delayed-Action Preparations↗

Support vector clustering for brain activation detection.

In this paper, we propose a new approach to detect activated time series in functional MRI using support vector clustering (SVC). We extract Fourier coefficients as the features of fMRI time series and cluster these features by SVC. In SVC, these features are mapped from their original feature space to a very high dimensional kernel space. By finding a compact sphere that encloses the mapped features in the kernel space, one achieves a set of cluster boundaries in the feature space. The SVC is an effective and robust fMRI activation detection method because of its advantages in (1) better discovery of real data structure since there is no cluster shape restriction, (2) high quality detection results without explicitly specifying the number of clusters, (3) the stronger robustness due to the mechanism in outlier elimination. Experimental results on simulated and real fMRI data demonstrate the effectiveness of SVC.

Algorithms↗