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De-min Han

Publications and source records attributed to De-min Han.

At least 37 records · Page 2Linked to original sources
PubMed2005

[Comparison of vocalization development between normal and congenitally hearing impaired infants during pre-language period].

OBJECTIVE: To compare the characteristics of vocalization and relevant perceptual characteristics between normal hearing infants and congenitally hearing impaired infants during pre-language period. METHODS: Speech spectrograms were analyzed, and the presentation time and frequency of pre-canonical babbling, canonical babbling, pointing behaviors and meaningful words were compared and statistically analyzed among 18 normal hearing infants, 11 profoundly congenitally hearing impaired infants that were divided into 2 groups: group A of deaf infants (n = 11) to be aided before 8 months of age and group B of deaf infant (n = 17) to be aided after 8 months of age. RESULTS: There was no significant difference in the presentation time and frequency of pre-canonical babbling among the 3 groups. Canonical babbling, pointing behaviors and meaningful words occurred the earliest and with the highest frequency in the normal hearing group, followed by the group A of deaf infants and group B of deaf infants in succession. CONCLUSION: Pre-canonical babbling appears in profoundly hearing impaired infants, suggesting that it is a kind of phonation activity free of hearing feedback. Better language development can be achieved when early intervention is carried out for congenitally hearing impaired infants within 8 months of age.

Age Factors↗
PubMed2005

[Effect of intranasal interleukin-12 gene therapy for allergic rhinitis in murine model].

OBJECTIVE: To investigate whether the local application of IL-12 gene with EBV-plasmid vector to nasal mucosa could prevent allergic inflammation in murine allergic rhinitis model. METHODS: Thirty-six BALB/C mice were randomly divided into allergic rhinitis group gene therapy group and control group. In mice with OVA-induced allergic rhinitis, the EBV/lipoplex (a novel cationic lipid combined with EBV-plasmid vector, pGEG. mIL-12) was locally administered into nasal mucosa before OVA challenge. The expression of IL-12 mRNA and protein, the change of eosinophilia and mast cell, and Th2 cytokine production in the nasal mucosa were measured. RESULTS: The amounts of IL-12 mRNA positive cells and IL-12 positive cells in nasal mucosa of gene therapy group were significantly higher than that of allergic rhinitis group (P < 0.01 and P < 0.05). The amount of eosinophils, mast cells, and the level of IL-5 expression in nasal mucosa in allergic rhinitis group were significantly higher than those in gene therapy group and control group (P < 0.01). The level of total IgE of peripheral blood in allergic rhinitis group was significantly higher than that in gene therapy group and control group (F = 1216.21, P < 0.01). CONCLUSIONS: These findings indicated that IL-12 mRNA and protein were expressed effectively after the local administration of pGEG. mIL-12 in the nasal mucosa. The local application of pGEG. mIL-12 is effective in modulating nasal allergic response and may be a convenient method for future approach to allergic rhinitis.

Animals↗
PubMed2005

[Modified intranasal endoscopic Lothrop procedure].

OBJECTIVE: To report the experience of modified endoscopic Lothrop procedure (MELP) in 6 cases and to discuss the operative technique and indications. METHODS: Six patients (four males and 2 females) aged from 6 to 63 years old with frontal sinus diseases were enrolled in this study, including 3 cases of frontal mucocele, 1 case of recurrent hemangioma, 1 case of recurrent inverted papilloma and 1 case of osteoma. All patients were underwent intranasal modified Lothrop procedure with the guidance of nasal endoscope. The image-guided navigational system was used for the location of frontal sinus in 2 cases. RESULTS: The operation was successful in all 6 patients without any operative and postoperative complications. The average operation time was 3.2 h. The endoscopic examination demonstrated the wide communicational frontal sinus openings and well epithelization after 6-40 months follow-up. The patients were asymptomatic up to now and no recurrence was found. CONCLUSIONS: The modified intranasal endoscopic Lothrop procedure is an ideal surgical approach for recalcitrant frontal sinus disorders on the basis of proper selection of surgical equipments and patients by the experienced surgeon.

Adolescent↗
PubMed2005

[Endoscopic frontal sinus surgery through agger nasi cell approach].

OBJECTIVE: To evaluate the access to the frontal recess by identifying the agger nasi cell and uncinate process. METHODS: Forty-seven patients (85 sides) who underwent endoscopic frontal sinus surgery in our department constituted the study population. Computed tomographic (CT) scans of the sinuses were obtained in coronal and axial views. The frontal ostium was identified by using agger nasi cell approach or identifying the uncinate process. RESULTS: The frontal sinus ostium was identified in 100% of patients (85 sides). After an average follow-up of 9 months, 41 sides of 49 sides (84%) had endoscopically healed sinuses by using agger nasi cell approach. And 21 sides of 36 sides (81%) had endoscopically healed sinuses by identifying the uncinate process. CONCLUSIONS: The agger nasi cell approach to the frontal recess gives an access and allows identification of the frontal ostium. In addition, it provides direct visualization with a 0 degree endoscope into the frontal recess.

Adult↗
PubMed2005

[Endoscopic surgery for nasal septal perforation].

OBJECTIVE: To describe the relevant factors of endoscopic surgery in patients with nasal septal perforation. METHODS: Twenty-three patients with nasal septal perforation were treated under nasal endoscope. Four kinds of reconstruction materials were used to accomplish the closure of perforation: residual osseous septum or temporalis fascia, inverting septal mucoperichondrial flap, autologous connective tissue insert overlaid with mucous flaps and turbinate flap. The reconstructed septum was packed by moist dressing with silicone or plastic splints. RESULTS: Seven patients underwent direct closure. Inverting flap repair for five cases, shifting flap closure for ten cases, and repair with turbinate flap in one case. During the follow-up ranging from four weeks to seven months, the successful reconstruction was achieved in 19 cases (82.6%). The problems in the remaining four cases were: mucosal flap displacement, fascia flap shrank and so caused reperforation, two perforations present with only the larger one repaired, the mucosal flap was smaller in size than the perforation. CONCLUSIONS: Intranasal endoscopic reconstruction surgery is a reasonable management for nasal septal perforation.

Endoscopy↗
PubMed2005

[Epidemic survey of the middle and aged women related obstructive sleep apnea hypopnea syndrome in Beijing].

OBJECTIVE: To find out the prevalence and risk factors related obstructive sleep apnea hypopnea syndrome (OSAHS) in Chinese women aged 40 years and older. METHODS Participants living in communities must be of age > or = 40 years and were given questionnaires, which developed a scale of 11 questions. Subjects were divided into three groups by scale scores. Those with higher scores were oversampled (2.4%, 14.8%, 42.1% respectively) and subjects of this community-based sample were recorded in the sleep laboratory to ascertain patients (apnea hypopnea index, AHI > or = 5/h and daytime sleepiness). Contrasting patients with the others as a control group, explored differences in symptoms. Stepwise multiple linear regression was used to determine the principal covariates affecting AHI. RESULTS: 34.3% of 1336 eligible women admitted various degree of snoring and 91.0% of those completed questionnaires. Crombach's alpha coefficient of scale reached 0. 7025. Factor analysis reduced 11 questions of scale to four common factors as we have designed: snoring, apneas, other symptoms, risk factors. Fifty-nine subjects experienced polysomnography evaluation. The ratios of patients to controls were 2: 25, 4: 18, 10: 16 from lower scores group to higher. We estimated the prevalence of AHI 5,10,15/h and OSAHS in this population were 41.1%, 24.0%, 17.0% and 11.1%, respectively. As far as the frequency of sleep choking, xerostomia or pharyngoxerosis in the morning, these were significant differences between the OSAHS and non-OSAHS groups. Stepwise multiple linear regression analysis identified serum level follicle-stimulating hormone and BMI as predictors of AHI. CONCLUSIONS: This scale had good validity and reliability. Snoring and OSAHS are very common in Chinese women 40 years of age and older. Women with OSAHS did report sleep choking, xerostomia or pharyngoxerosis in the morning. BMI and sex steroids may all play a role in OSAHS.

Adult↗
PubMed2005

[Anatomical and computed tomographic analysis of the interaction between uncinate process and agger nasi cells].

OBJECTIVE: To investigate the anatomical interaction between uncinate process and agger nasi cell to better understand the anatomy of the frontal sinus drainage pathway by endoscopy, spiral computed tomography (CT) and sectioning. METHODS: Twenty-one skeletal skulls (forty-two sides) and one cadaver head (two sides) were studied by spiral CT together with endoscopy and collodion embedded thin sectioning at coronal plane. The sections with the thickness of 100 microm were stained with hemotoxylin and eosin. RESULTS: Under endoscopy, a leaflet of bone to the middle turbinate, which is given off by uncinate process, forms the anterior insertion of the middle turbinate onto the lateral nasal wall. The middle portion of the uncinate process attached to the frontal process of the maxilla in all of the skeletal nasal cavities, as well as the lacrimal bone in 78.6% of the skeletal nasal cavities. On CT scans, the agger nasi cell is present in 90.5% of the skeletal nasal cavities. While the lateral wall of the agger nasi cell is formed by lacrimal bone, the medial wall of the agger nasi cell is formed by uncinate process. And the anterior wall is formed by the frontal process of the maxilla. The superior portion of the uncinate process forms the medial, posterior and top wall of the agger nasi cells. The superior portion of the uncinate extends into the frontal recess and may insert into lamina papyracea (33.3%), skull base (9.5%), middle turbinate, combination of these (57.2%). CONCLUSIONS: The agger nasi cell is the key that unlocks the frontal recess.

Adult↗
PubMed2004

[Electrically stimulated olfactory evoked potential in olfactory-lesioned rabbit].

OBJECTIVE: To develop olfactory dysfunctioned animal model by injuring olfactory blub(s) and to investigate the characteristics of olfactory evoked potential. METHODS: The changes of OEP in rabbits were observed at 24 h, 48 h and 1 w after olfactory bulb(s) were electrolytically injured. The pathological and ultrastructural changes of olfactory mucosa and olfactory bulb were also observed. RESULTS: When unilateral olfactory bulb was damaged, N2 vanished with elongated latencies and lowered amplitudes of N1 and P1. When both olfactory bulbs were damaged, N1 and N2 were absent, only P1 could be recorded. The latency was extended obviously and the amplitude had a big change. Histopathology and ultrastructure showed that there were a lot of inflammatory cells and degenerated neurons scattered around OB 24 hours to 48 hours after injure. It was observed that the olfactory cilia had distraction perversion and colliquefaction changes. CONCLUSION: Different degree of olfactory bulb injury caused different effect on OEPs. These changes of potential were based on the histopathology and ultrastructure.

Animals↗
PubMed2004

[Multi-channel cochlear implants in patients with Mondini malformation].

OBJECTIVE: To describe clinical experiences with multi-channel cochlear implantation in patients with Mondini malformation. METHODS: Among 300 patients who received multi-channel cochlear implants from 1996 to 2002 in Beijing Tongren Hospital, 15 patients were diagnosed with Mondini malformation. A retrospective analysis was performed dealing with the surgical techniques, mapping and rehabilitations characteristics after surgery. 15 patients with normal cochlear structure are consider as control group. RESULTS: Gusher is found more common than the normal cochlear implantation, most of them are serious. The electrodes are inserted in the "cochleostomy" in full length of 13 Patients, 2 pairs of electrodes remains outside of "cochleostomy" in 2 patients. No serious complications occurred after implantation. All patients have auditory sensations. The impedance of the electrodes, the T level, C level and the hearing threshold are similar with the normal cochlear implantation group. The results have no significant difference in compare with normal cochlear group(P > 0.05). CONCLUSION: Multi-channel cochlear implantation could be performed safely in patients with Mondini malformation. The primary outcome for patients with Mondini malformation are similar to those with normal cochlear structure following the multi-channel cochlear implantation.

Adolescent↗
PubMed2004

[Relationship between the severity, course, fatality of severe acute respiratory syndrome patients and the timing of hospitalization].

OBJECTIVE: To study the relationship of timing of hospitalization and the severity, course, fatality of severe acute respiratory syndrome (SARS) patients. METHOD: 1291 hospital records of clinically diagnosed SARS patients with complete data gathered from "2003 Beijing SARS Clinical Database" were analyzed. RESULTS: SARS cases were categorized into four groups, according to the time of hospitalization after onset of the disease: within 3 days, during day 4 to day 7, during day 8 to day 14 and after day 14. The numbers of cases for each group were 568, 496, 177 and 50 respectively. Data showed that from group 1 to 4, the prevalence rates of major symptoms on the first day of hospitalization were: (1) 9.7%, 16.5%, 23.1% and 24.0% for "feeling chest pain" (P < 0.001), (2) 7.4%, 13.7%, 19.2% and 22.0% for "suffering from breathing obstruction" (P < 0.001), (3) 32.8%, 44.8%, 59.9% and 48.0%, for "coughing" (P < 0.001) and (4) 14.1%, 22.4%, 27.1% and 18.0% for "coughing up phlegm" (P = 0.0002), respectively. The rates of high respiratory frequency (>or= 24 bits/min.) were 11.1%, 15.5%, 22.8% and 25.5% (P < 0.001). The rates of abnormal chest X-ray were 80.3%, 89.0%, 92.3% and 88.9%, respectively (P = 0.002). The average numbers of abnormal lung field (the lung were divided into 6 fields) were 1.7, 1.9, 2.5 and 2.6 (P < 0.001); The numbers of cases receiving continuous oxygen supply treatment were 33.6%, 50.0%, 53.7% and 74.0% (P < 0.001), and the numbers of cases receiving glucocorticosteroids treatment were 28.2%, 35.9%, 53.7% and 62.0% (P < 0.001), respectively. With cases having had chronic baseline diseases prior to SARS infection, the age-standardized fatality rates were 14.9%, 11.7%, 50.0% and 33.9% (P < 0.001), and the average courses of the disease were 30.3, 34.2, 42.9 and 47.5 days (P < 0.001), respectively. In cases without chronic baseline diseases, the age-standardized fatality rates were 5.3%, 9.8%, 9.2% and 8.3% (P = 0.101), and the average courses for each group were 32.4, 35.3, 40.9 and 47.6 days (P < 0.001), respectively. CONCLUSION: Delayed hospitalization would cause the situation of SARS patient to deteriorate, losing the best chance for treatment and increase case fatality. In terms of control program on SARS, emphasize should be paid on decreasing the panic of patients to the disease so as to get early hospitalization.

Adolescent↗
PubMed2004

[Analysis on the cost and its related factors of clinically confirmeds severe acute respiratory syndrome cases in Beijing].

OBJECTIVE: To explore the medical cost and its related factors of clinically confirmed severe acute respiratory syndrome (SARS) cases in Beijing. METHODS: The average medical cost per person/day was calculated on 1272 SARS cases with complete hospitalization data from the Beijing SARS clinical database. Factors associated with medical expenditure were explored by both single factor and multi-factor analyses. RESULTS: The medical costs of SARS patients in Beijing were 18 767.50 RMB/case and 632.02 RMB/day/case. Expenses on medication accounted for the highest proportion (0.66%). The increase in expenses on medication was significantly associated to the increase in total expenditure. Analyses by single factor, factor stratification as well as multi-factor analyses showed that: the expenditure increased significantly with the following factors of the patients: prolonged days of hospitalization, severe symptoms and signs, hospitalization at the early stage of disease onset, being medical staff themselves, with baseline diseases, being applied mechanical ventilation, and with medical insurance. CONCLUSIONS: The medical expenditure on SARS patients at the hospital was higher than that on patients with common diseases which was associated to the following factors as: days of hospitalization, severity of disease, stage of the disease break-out, patient's occupation, baseline disease status, medical insurance status etc.

Age Factors↗
PubMed2004

[Imaging-navigated endoscopic sinus surgery].

OBJECTIVE: To evaluate the advantages and disadvantages of different type of image-guidance system in endoscopic sinus surgery. METHODS: Fifty-three endoscopic sinus surgery were performed under different type of image-guidance system, there were 24 chronic sinusitis with or without nasal polyp, 4 juvenile nasopharyngeal angiofibroma, 8 pituitary adenoma, 9 ethmoid ossifying fibroma, 2 nasopharyngeal mixed tumor, 1 nasal leiomyoma, 3 fungal sinusitis, and 2 inverting papilloma. RESULTS: In all cases, the preoperative time was 15-30 minutes, the registration rate were 1.3-2.0, the localization accuracy was within 1 mm. Compared with the traditional endoscopic sinus surgery, the operating time was similar, without obvious difference. No complication occurred. CONCLUSION: All types of image-guidance system could work well with endoscopic system, each of them had its own shortages. Every type of image-guidance system could identify the borders and critical anatomical structures in the corresponding CT data, especially in cases in which anatomical landmarks were no longer present, with anatomical variation, intranasal and anterior skull base tumor. Combined with endoscopic surgery, the image-guided endoscopic surgery provided accurate tumor resection while preserving normal tissue, increased surgical effectiveness, decreased overall surgical complications. It is believed that the image-guidance system is a useful tool for endoscopic sinus surgery.

Adolescent↗