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Biomedical subjects

David S Goodsell

Publications and source records attributed to David S Goodsell.

61 records · Page 4Linked to original sources
PubMed2002

A hierarchical model of HIV-1 protease drug resistance.

A hierarchical model of HIV-1 drug therapy may be used to evaluate new inhibitors and test new treatment strategies that address the problem of drug resistance. The model includes an atomic representation of drug-protease interaction, evaluation of viral fitness based on cleavage of polyprotein substrates during viral maturation, evolutionary modelling of drug resistance mutations in the face of selection pressures by drug and a mathematical description of viral population dynamics in infected individuals. These techniques have been used for the design of resistance-evading inhibitors by computational coevolution techniques and for the optimisation of existing protease inhibitors for improving their robustness in the face of resistance mutation.

Catalytic Domain↗
PubMedDate not supplied

Recognition in action: DNA mimicry.

Proteins that mimic DNA present a surface that is similar in shape and chemical character to the DNA double helix. These DNA mimics bind to DNA-binding proteins, taking the place of DNA. Natural DNA mimics play roles in genetic regulation and defense.

DNA↗
PubMedDate not supplied

Recognition highlights: Toll-like receptors.

As part of our first line of defense against invading organisms, Toll-like receptors recognize bacterial and viral molecules, and launch an inflammatory response.

Humans↗