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Biomedical subjects

David J Rothman

Publications and source records attributed to David J Rothman.

13 recordsLinked to original sources

Serving Clio and client: the historian as expert witness.

Although historians often appear in court as expert witnesses, their presence stirs unease and controversy. To clarify the issues at stake, this article compares two activities-testifying on behalf of plaintiffs, and conducting an open-ended historical inquiry-by using the author's personal experience in Craft v. Vanderbilt as a case in point. The litigation sought to gain compensation and an apology for the 830-850 women who between 1945 and 1949 at the Vanderbilt prenatal clinic were fed doses of radioactive iron without their consent so as to study the process of iron absorption. The overall conclusion is that historians can serve clients without subverting the canons of the discipline. However, because Clio and client have such different needs, historians should recognize, and take pride in the fact, that courtroom appearances represent advocacy.

Expert Testimony↗

Is there an antiaging medicine?

In spite of considerable hype to the contrary, there is no convincing evidence that currently existing so-called "antiaging" remedies promoted by a variety of companies and other organizations can slow aging or increase longevity in humans. Nevertheless, a variety of experiments with laboratory animals indicate that aging rates and life expectancy can be altered. Research going back to the 1930s has shown that caloric restriction (also called dietary restriction) extends life expectancy by 30-40% in experimental animals, presumably at least partially by delaying the occurrence of age-dependent diseases. Mutations that decrease production of insulin growth factor I in laboratory mammals, and those that decrease insulin-like signaling in nematodes and fruit flies, have increased life expectancy as well. Other general strategies that appear promising include interventions that reduce oxidative stress and/or increase resistance to stress; hormone and cell replacement therapies may also have value in dealing with specific age-related pathologies. This article reports the findings of a consensus workshop that discussed what is known about existing and future interventions to slow, stop, or reverse aging in animals, and how these might be applied to humans through future research.

Aging↗

Radiation.

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Administrative Personnel↗

Rationing life.

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Aged↗

New rules for new drugs: the challenge of AIDS to the regulatory process.

AIDS is systematically changing attitudes and practices regarding the regulation and use of drugs. The complex framework and rigorous research protocols developed by the Food and Drug Administration prior to the 1980s to minimize risk to subjects is shifting in the epidemic's wake to maximize innovation. The FDA has adopted new procedures hastening access to investigational drugs and easing drug importation for personal use, which, in effect, transfers decisions about the benefits and risks of drugs from the agency's staff to patients and their physicians. While the FDA's tilt toward embracing consumer rights may continue in the near future, disappointing results could prompt the agency to reassert its authority in controlling drug policy more restrictively.

Acquired Immunodeficiency Syndrome↗

Spare parts.

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Cadaver↗