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Biomedical subjects

David Hochberg

Publications and source records attributed to David Hochberg.

4 recordsLinked to original sources

Spatiotemporal patterns driven by autocatalytic internal reaction noise.

The influence that intrinsic local-density fluctuations can have on solutions of mean-field reaction-diffusion models is investigated numerically by means of the spatial patterns arising from two species that react and diffuse in the presence of strong internal reaction noise. The dynamics of the Gray-Scott (GS) model [P. Gray and S. K. Scott, Chem. Eng. Sci. 38, 29 (1983); and ibid.39, 1087 (1984); and J. Phys. Chem. 89, 22 (1985)] with a constant external source is first cast in terms of a continuum field theory representing the corresponding master equation. We then derive a Langevin description of the field theory and use these stochastic differential equations in our simulations. The nature of the multiplicative noise is specified exactly without recourse to assumptions and turns out to be of the same order as the reaction itself, and thus cannot be treated as a small perturbation. Many of the complex patterns obtained in the absence of noise for the GS model are completely obliterated by these strong internal fluctuations, but we find novel spatial patterns induced by this reaction noise in the regions of parameter space that otherwise correspond to homogeneous solutions when fluctuations are not included.

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Large-scale emergent properties of an autocatalytic reaction-diffusion model subject to noise.

The nonequilibrium dynamic fluctuations of a stochastic version of the Gray-Scott (GS) model are studied analytically in leading order in perturbation theory by means of the dynamic renormalization group. There is an attracting stable fixed point at one-loop order, and the asymptotic scaling of the correlation functions is predicted for both spatial and temporally correlated noise sources. New effective three-body reaction terms, not present in the original GS model, are induced by the combined interplay of the fluctuations and nonlinearities.

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Noise-controlled self-replicating patterns.

We present novel numerical evidence of spot self-replication controlled by noise in a simple autocatalytic reaction-diffusion system. The system dynamics exhibits a noise controlled transition from stripe growth to spot replication. The growth kinetics is also controlled by noise, and there is an optimal noise intensity for which the multiplication rate of spots is maximal. For larger noise intensities, the spots become unstable and the system is attracted by the trivial steady state. Some of the effects are reminiscent of both polymer chain and cell colony formation in random environments.

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Large-scale features of rotating forced turbulence.

Large-scale features of a randomly isotropically forced incompressible and unbounded rotating fluid are examined in perturbation theory. At first order in both the random force amplitude and the angular velocity, we find two types of modifications to the fluid equation of motion. The first correction transforms the molecular shear viscosity into a (rotation independent) effective viscosity. The second perturbative correction leads to a new large scale nondissipative force proportional to the fluid angular velocity in the slow rotation regime. This effective force does no net work and alters the dispersion relation of inertial waves propagating in the fluid. Both dynamically generated corrections can be identified with certain components of the most general axisymmetric "viscosity tensor" for a Newtonian fluid.

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