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David H Spodick

Publications and source records attributed to David H Spodick.

At least 37 records · Page 2Linked to original sources
PubMed2006

Optimal P-wave duration for bedside diagnosis of interatrial block.

BACKGROUND: Interatrial block (IAB; P wave > or = 110 ms) is highly prevalent and associated with atrial tachyarrhythmias, left atrial electromechanical dysfunction and is a potential risk for embolism. Investigators have often used different parameters for P-wave duration to define IAB, and this causes confusion further adding to clinician ignorance of IAB. We therefore appraised the mode P-wave duration in IAB and evaluated the sensitivity and specificity of using previously used durations. METHODS: We prospectively evaluated 225 electrocardiograms (ECGs) of patients at a tertiary care general hospital for P-wave duration. Of these, 49 were excluded because of severe motion artifact, errors in lead placement, absence of adequate patient identification, and atrial flutter or fibrillation. Mean, standard error of mean (SEM), standard deviation (SD), mode P-wave duration, specificity, and sensitivity were calculated of the remaining 176 ECGs. RESULTS: From the sample (N = 176; ages 15-95 years; mean +/- SD = 69.15 +/- 16.53 years, female 50.3%), measured P-wave durations ranged from 50 ms to 230 ms (mean +/- SD = 113.75 +/- 30.56 ms, SEM 2.30 ms). 96 patients (54.55%) showed IAB (P wave > or = 110 ms) with the mode P-wave duration being 120 ms. Sensitivity and specificity of using P wave > or = 110 ms is 100% and 88.9%, respectively (accuracy 94.31%), while P wave > or =130 ms yielded 64% and 100%, respectively (accuracy 82.38%). CONCLUSIONS: Mode P-wave duration in IAB is 120 ms, and thus, for all practical reasons, it may be used to clinically diagnose IAB using ECGs recorded at the bedside at 25 mm/s with 10 mm/mV standardization.

Adolescent↗
PubMed2005

Progression of partial to advanced interatrial block.

Interatrial block (IAB), prolonged conduction between the atria, is denoted by P waves of 110 milliseconds or more and may manifest as partial or advanced. Theoretically, partial IAB may progress to its advanced counterpart if conduction delay increases to complete block. However, there have been no reports of such progression, and electrophysiologic studies have not shown this phenomenon. We briefly review the interatrial conducting pathways of IAB and present the first documentation of possible progression of partial to advanced IAB.

Aged↗
PubMed2005

Clinician underappreciation of interatrial block in a general hospital population.

INTRODUCTION: Interatrial block (IAB; P wave > or =110 ms), a conduction delay between the right and left atria (LA), is highly prevalent and strongly associated with atrial tachyarrhythmias, LA electromechanical dysfunction as well as a risk of embolism. Nonetheless, clinicians' underappreciation of its existence and sequelae remains. We appraised this issue in a general hospital population. METHODS: From the database of 730 12-lead electrocardiograms (ECGs) of patients aged 17-98 years (mean age 67.80 years; female patients 53.56%) in a tertiary care teaching general hospital, we recorded the computer-generated diagnostic readings of the ECGs and also the official cardiologist and hospitalist ECG interpretations and documentations. For increased sensitivity and specificity, and because the mode P wave duration in IAB is 120 ms, P waves > or =120 ms in any lead were used to diagnose IAB. RESULTS: Six hundred and fifty-three ECGs (89.45%) showed sinus rhythm, and of those, IAB was documented on 309 ECGs (47.32%). LA enlargement was cited 29 times (3.97%), while possible LA enlargement and biatrial enlargement were cited 17 (2.32%) and 6 times (0.82%), respectively. One cardiologist's ECG interpretation documented IAB (0.32%), but none of the other medical staff diagnosed IAB or abnormal P wave duration. CONCLUSION: This study demonstrates to extremes how IAB went undiagnosed in a general hospital population. Until more awareness of IAB is cultivated, such ignorance of the existence and sequelae of IAB could continue. Configuring ECG software to include P wave durations in computer-generated ECG readings could be useful in aiding diagnosis.

Adolescent↗
PubMed2005

Confirmation of the prevalence and importance of a 12-lead investigation for diagnosis of interatrial block [corrected].

We investigated 500 consecutive, unselected electrocardiograms of outpatients for interatrial block (IAB) using all 12 leads rather than the usual recommendation in the literature, which is lead II, sometimes with another lead. IAB had been reported in 2 widely separated large general hospitals in >40% of 1,000 patients in sinus rhythm in each. Because the P waves in IAB (duration > or =110 ms) generally have low amplitude despite their excessive width, we used magnifying graticules and, for greater specificity, a minimal duration of > or =120 ms. Four hundred sixty-nine patients remained after excluding those with atrial arrhythmias or technically poor tracing. Two hundred three of these patients (40.6%) had IAB. Had we used lead II alone, only 110 cases would have been identified, which would have meant overlooking almost 1/2 the cases with this lesion, which is important (1) as a predictor of atrial fibrillation and other arrhythmias, and (2) represents a large, dysfunctional left atrium. Leads V3 and V4 yielded larger numbers of IAB than lead II. (The slightly smaller prevalence than in the 2 cited studies may be due to our using 1/2 the number of patients.) Electrocardiographic interpreters should seek IAB in all 12 leads and consider its anatomic functional and predictive correlates.

Diagnosis, Differential↗
PubMed2005

Widely split P waves in the presence of interatrial block.

Interatrial block (IAB; P wave>or=110 milliseconds), conduction delay between the atria, is highly prevalent and is associated with atrial tachyarrhythmias, left atrial electromechanical dysfunction, as well as a potential risk for systemic embolism. However, much is still yet to be known of IAB's exact pathophysiology and how it may manifest in relation to medical disease. We present an unusual case of widely split P waves in the presence of IAB in a severely ill patient.

Aged↗
PubMed2005

Pretreatment with corticosteroids attenuates the efficacy of colchicine in preventing recurrent pericarditis: a multi-centre all-case analysis.

AIMS: Effective prevention of recurrent pericarditis remains an important yet elusive goal. Corticosteroid therapy often needs to be continued for a prolonged period and causes severe side effects. We performed a multi-centre all-case analysis to investigate the efficacy of colchicine in preventing subsequent relapses of pericarditis, and addressed the hypothesis that pretreatment with corticosteroids may attenuate the beneficial effect of colchicine. METHODS AND RESULTS: One hundred and forty published and unpublished cases of patients treated with colchicine after at least two relapses of pericarditis were aggregated from European centres. Of those, 119 were included in the study group. Only 18% of the patients had relapses under colchicine therapy, and 30% after its discontinuation. There were significantly more relapses among male patients after colchicine treatment (36 vs. 17%, P=0.046), and those with previous corticosteroid treatment (43 vs. 13%, P=0.02). Multivariate logistic regression analysis identified previous corticosteroid therapy (OR 6.68, 95% CI: 1.65-27.02) and male gender (OR 4.20, 95% CI: 1.16-15.21) as independent risk factors for recurrence following colchicine therapy. CONCLUSION: Treatment with colchicine is highly effective in preventing recurrent pericarditis, while pretreatment with corticosteroids exacerbates and extends the course of recurrent pericarditis.

Adolescent↗
PubMed2005

Interatrial block as a predictor of embolic stroke.

Interatrial block (IAB), defined as a prolonged (>/=110 ms) P wave, is remarkably prevalent in general hospital populations and is associated with an enlarged, poorly contractile left atrium. The investigators sought to determine whether there is an increased incidence of IAB in patients with embolic strokes. Patients' medical records were reviewed for evidence of embolic cerebrovascular events and IAB. One hundred four patients were identified. In 61 patients in normal sinus rhythm, 49 (80%) had IAB. This was almost twice the prevalence of 2 previous studies (41% and 47%). Therefore, IAB may represent a new risk factor for stroke.

Adult↗
PubMed2005

Interatrial block: pandemic prevalence concealed by anachronistic electrocardiographic standards.

BACKGROUND: Interatrial block (IAB; P waves 2 > or =110 ms duration) has been reported in over 40% of unselected patients in sinus rhythm at widely separated general hospitals. It is thus of "pandemic" proportions. It should be better appreciated because it represents a large, baggy, poorly functional left atrium and is a forerunner of atrial fibrillation, atrial flutter, and other arrhythmias. HYPOTHESIS: A search of all 12 leads will disclose the true prevalence of IAB in contrast to traditional reliance on lead II, as widely proposed in textbooks and other literature. METHODS: In all, 500 consecutive unselected electrocardiograms (ECGs) were investigated using every lead and a magnifying graticule. For greater specificity, a minimal P duration of > or =120 ms was selected. RESULTS: Thirty-one ECGs were discarded because of atrial arrhythmia, poor baseline, or undetectable P waves, leaving a base of 469 ECGs, the denominator for the results. A total of 182 patients had IAB, representing 38.8% of this series. The widest P wave was usually found in multiple leads (95.1% of patients). The widest P waves were found only in precordial leads in 59 patients and only in limb leads in 18 patients. "Traditional" lead II detected only 97 cases (53.3%), and IAB was found more frequently in leads V3 and V4. CONCLUSIONS: Results confirm the pandemic frequency of IAB in one-third of hospitalized patients. Interpreters of ECGs should seek IAB in all 12 leads since reliance on lead II alone resulted in only 53.3% of the total cases. Its prevalence and serious implications with regard to patients' current and future status make this necessary.

Electrocardiography↗
PubMed2005

Evidence supporting a new rate threshold for multifocal atrial tachycardia.

BACKGROUND: Exacerbation of chronic obstructive pulmonary disease (COPD) is overwhelmingly represented among patients presenting with multifocal atrial tachycardia (MAT) and has been used as a paradigm for such patients. The quasidiagnostic tachycardia threshold for MAT is conventionally set at 100 beats/min. Nevertheless, this threshold has not been demonstrated to be optimal. HYPOTHESIS: Using COPD as a paradigm for MAT, clinical experience led to the hypothesis that MAT with a tachycardia threshold < 100 beats/min could be more closely associated with COPD exacerbation. METHODS AND RESULTS: We reviewed 60 consecutive patients with multifocal atrial arrhythmia (MAA) at any heart rate and found a better association between the incidence of COPD exacerbations and MAT using a tachycardia threshold of 90 beats/min (p = 0.00036) than when using a threshold of 100 beats/min (p = 0.515). CONCLUSION: The rate threshold of MAT should be reduced from 100 to 90 beats/min.

Aged↗
PubMed2005

Letter by Spodick.

Explore the source record for details and available documents.

Electrocardiography↗
PubMed2005

Interatrial block during exercise tolerance tests as an additional parameter for the diagnosis of ischemic heart disease.

INTRODUCTION: Interatrial block (IAB; P-wave duration, >or=120 milliseconds) is associated with increases of left atrial pressure. We studied the use of IAB during exercise tolerance test (ETT) in diagnosis of ischemic heart disease. METHOD: Exercise tolerance tests were performed in 149 patients (mean age, 50 years; male, 60.4%). P-wave duration was measured at rest, at each stage of exercise using the Bruce protocol, and in recovery. As clinically indicated, 71 patients subsequently underwent nuclear stress test and/or catheterization. The evidence of ischemia (EOI) was considered present according to the more definite test, that is, catheterization over nuclear stress test over ETT. RESULTS: Among patients who did not have IAB at rest (n=115), 63 patients (54.7%) developed IAB during the ETT. The incidence of IAB during the ETT was higher in patients with EOI than patients without EOI (88.9% vs 51.9%, P=.03). When IAB during the ETT and positive ETT were used together to detect EOI, they were more accurate (86.1% vs 81.7%) than the ETT alone. Among patients with IAB at rest (n=34), patients with EOI had a higher incidence of P-wave duration increase of more than 20 milliseconds during the recovery period than patients without EOI (100% vs 21.8%, P=.015). When using P-wave duration increase of more than 20 milliseconds during the recovery period in conjunction with positive ETT, the sensitivity in detecting EOI was higher than using the ETT alone (100% vs 0%), but the specificity was worsened (68.8% vs 84.4%). CONCLUSION: New IAB and worsening of IAB during ETT appeared in patients with ischemic heart disease and may be used as additional parameters for the ETT interpretation.

Adult↗