Biomedical subjects

David Crewther

Publications and source records attributed to David Crewther.

5 recordsLinked to original sources

PubMed2006

Distractibility in AD/HD predominantly inattentive and combined subtypes: the P3a ERP component, heart rate and performance.

The current study aimed to investigate whether children and adolescents diagnosed with Attention Deficit/Hyperactivity Disorder Predominantly Inattentive (AD/HD-in; Child n = 24, Adolescent n = 33) and Combined (AD/HD-com; Child n = 30, Adolescent n = 42) subtypes were more distractible than controls (Child n = 54; Adolescents n = 75), by assessing event-related potential (ERP), performance and peripheral arousal measures. All AD/HD groups displayed smaller amplitudes and/or shorter latencies of the P3a ERP component - thought to reflect involuntary attention switching - following task-deviant novel stimuli (checkerboard patterns) embedded in a Working Memory (WM) task. The P3a results suggested that both AD/HD-in and AD/HD-com subtypes ineffectively evaluate deviant stimuli and are hence more "distractible". These abnormalities were most pronounced over the central areas. AD/HD groups did not display any abnormalities in averaged heart rate over the WM task, a measure of peripheral arousal. They did display abnormalities in performance measures from the task, but these were unrelated to P3a abnormalities. AD/HD groups also displayed a number of deficits on Switching of Attention and Verbal Memory tasks, however, the pattern of abnormality mostly reflected general cognitive deficits rather than resulting from distraction.

Adolescent↗

PubMed2004

Rate of learning and asymptotic performance in an automatization task and the relation to reading.

In the present study, direct evidence was sought linking cognitive automatic processing with reading in the general adult population. Reading speed on single-task performance and dual-task performance were compared. A total of 18 adults without dyslexia participated (7 men and 11 women, age M=25.3 yr., SD=2.7). Participants initially were trained in single-task mode on two types of tasks. The first was a central alphanumeric equation task (true or false), which comprised 3 subtests of increasing difficulty, ranging from an easily automated task to a varied and unpredictable mathematical operation. The second task was a peripheral pattern subitization task for which stimulus exposure time was related to performance. Finally, participants received dual-task training, which required simultaneous processing of both tasks. Slower reading speed was significantly related to rate of learning and speed of performance on predictable alphanumeric operations in dual-task conditions. There was no effect of reading speed on performance in the varied alphanumeric task. Faster readers were no better than slower readers on the pattern-subitization task. These findings suggest that faster readers automatized the predictable alphanumeric task more rapidly than slower readers and hence were better able to cope with the dual-task condition.

Achievement↗

PubMed2003

Central and peripheral vision loss associated with nefazodone usage.

A 35-year-old woman who reported persistent significant vision loss for 3 years after taking the antidepressant nefazodone was referred for electrophysiological assessment of vision. The vision changes included reduced acuities, reduced colour vision and visual field constriction in both eyes and were thought to be associated with the use of nefazodone for 6 - 8 weeks, 3 years earlier. Multifocal electroretinograms and visual evoked potentials were recorded using the Visual Evoked Response Imaging System (VERIS) to investigate the nature and site of the neural deficit. The summed retinal response showed a normal a- and b-wave latency and amplitude, however, the retinal topographic mfERGs showed a severe depression of the macular response in both eyes. The cortical topographic multifocal VEP mapping also showed a central depression in the right eye compared with the left. Two-frame motion and pattern custom mfVEP were also measured to assess different forms of cortical processing and especially of motion as nefazodone has previously been associated with image persistence with moving stimuli. The responses to two frame-motion showed signs of abnormality. Thus these results suggest that the primary locus of neural damage is retinal and is likely to have resulted from neurotoxicity. Other competing hypotheses such as hysterical blindness must be ruled out.

Adult↗

PubMedDate not supplied

Strabismic amblyopia. Part 1. Psychophysics.

This is a two-part survey of current literature concerning strabismic amblyopia. The aim of this review is to bring the optometric practitioner up to date on the status of scientific research into strabismic amblyopia. Part 1 in this series discusses research into strabismic amblyopia from the viewpoint of psychophysical experiments that investigate both spatial and temporal behavioural deficits accompanying strabismic amblyopia. These include deficits in contrast sensitivity, spatial localisation, fixation, ocular motility, accommodation, crowding, attention, motion perception and temporal processing. Part 2 will evaluate neural processing in regard to strabismic amblyopia. It will discuss current understanding of aspects of central processing of visual information and theories regarding neural sites and mechanisms involved in amblyopia.

Journal Article↗

PubMedDate not supplied

Strabismic amblyopia. Part 2. Neural processing.

This is the second of a two-part survey of current literature concerning strabismic amblyopia. The aim of this review is to bring the optometric community up to date on the status of scientific research into strabismic amblyopia. Part 1 in this series discussed research into strabismic amblyopia from the viewpoint of psychophysical experiments, which investigate both spatial and temporal behavioural deficits accompanying strabismic amblyopia. These include deficits in contrast sensitivity, spatial localisation, fixation, ocular motility, accommodation, crowding, attention, motion perception and temporal processing. Part 2 concerns neural processing in regards to strabismic amblyopia. It discusses current understanding of more fundamental aspects of central processing of visual information and in particular current theories regarding neural sites and mechanisms involved in amblyopia.

Journal Article↗