Biomedical subjects

Daria Finke

Publications and source records attributed to Daria Finke.

4 recordsLinked to original sources

PubMed2005

[The spectrum of congenital malformations of the urinary tract in fetuses and newborns in autopsies in 1989-2002].

The retrospective analysis of own autopsy findings of 831 fetuses and newborns with different forms of congenital malformations were carried out. In 172 cases (20.7%) urinary tract abnormalities were revealed. Isolated malformations represented 43.6% (75 cases) and 56.4% (97 cases) constituted one component of complex multisystem anomalies. Obstructive uropathies with different renal changes represented 54.7% of the isolated malformations, renal agenesis - 28%, autosomal recessive or dominant polycystic renal diseases - 16% and renal hypoplasia 1.3%. Obstructive uropathies were also most prevalent among the multisystem abnormalities (45.4%), while agenesis represented 34% of cases, horseshoe kidney - 12.4%, autosomal polycystic kidney diseases 4.1%, and renal hypoplasia 4.1%. Congenital abnormalities of urinary tract (especially the obstructive uropathies and agenesis) were more common in male fetuses and newborns. A highly frequent coexistence of urinary system congenital abnormalities and malformations of digestive tract, circulatory system and central nervous system were observed.

Abnormalities, Multiple↗

PubMed2003

[Concentration of tissue plasminogen activator and its inhibitor 1 in cyclosporine A-treated children with idiopathic nephrotic syndrome].

UNLABELLED: Patients with idiopathic nephrotic syndrome (INS) are at increased risk of thromboembolic events at every stage of the disease. We assessed the function of the coagulation cascade and fibrinolysis in stable remission of INS, in children treated with cyclosporine A. MATERIAL: The study group consisted of 17 children (10 M, 7 F; mean age 8.5 +/- 3.2 years, range 4-18 years) with 2 month-remission of steroid-dependent INS diagnosed according to the international criteria and 20 healthy, age-matched children, and 18 children in long-term INS remission serving as controls. The children with INS relapse were treated with cyclosporine A (to maintain the drug concentration value between 80 and 150 ng/ml) and low doses of steroids, according to a standard protocol. METHODS: Fibrinolysis was assessed by measurement of tissue plasminogen activator (t-PA) and tissue plasminogen activator inhibitor (PAI-1) concentrations, whereas activation of thrombinogenesis was detected by F1 + 2 prothrombin fragment concentration. Additionally, we measured selected coagulation (concentration of thrombin-antithrombin complexes, fibrinogen concentration, prothrombin time, activated partial thromboplastin time, platelet count) and biochemical (serum albumin, cholesterol, creatinine concentration) factors. RESULTS: In children treated with cyclosporine A increased concentrations of t-PA and PAI-1 were found (p < 0.01). The concentration of F1 + 2 prothrombin fragments was also higher when compared to controls (p < 0.05). We found also increased total cholesterol, and lower creatinine concentration in the study group. CONCLUSION: Children with remission of idiopathic nephrotic syndrome treated with cyclosporine A show increased concentration of t-PA and PAI-1 and thrombinogenesis. Despite clinical and biochemical remission they may still remain at high risk of thrombosis or endothelial injury.

Adolescent↗

PubMed2003

[Assessment of children at the beginning of renal replacement therapy in Lodz 1990-2000].

The time of patients' referral to dialysis predicts the clinical outcome of the therapy and significantly influences the mortality rate. The aim of the study was to assess the clinical and nutritional status and selected biochemical parameters (serum creatinine, urea, bicarbonate, calcium, albumin concentration) at the beginning of renal replacement therapy. We analysed medical history of 46 children (24 boys; 22 girls) aged 1 month-18 years (mean age 13.1 +/- 5.5 years). We divided them into late-referral and early-referral groups. 56% of the children were under nephrological care before the beginning of dialysis treatment. However, in 44% of the cases renal insufficiency had not been diagnosed before. It was found that the children who received no nephrological care in the past demonstrated significantly worse clinical and biochemical status at the beginning of the renal replacement therapy.

Adolescent↗

PubMed2002

[Shunt nephritis].

The term "shunt nephritis" stands for an immune-complex-mediated glomerulonephritis which develops as a complication of chronically infected ventriculoatrial or rarely ventriculoperitoneal shunt inserted for the treatment of hydrocephalus. The renal outcome of shunt nephritis is good if early diagnosis and treatment is provided. Due to a wide clinical spectrum of this disorder, as well as indolent courses of shunt infections, the diagnosis is often delayed. We present the case of 13-year-old girl with a severe course of shunt nephritis in whom the diagnosis was both overlooked and delayed. Misinterpretation of her symptoms led to erroneous diagnosis of lupus nephritis and introduction of immunosuppressive therapy.

Acute Kidney Injury↗