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Biomedical subjects

Daniel Shedid

Publications and source records attributed to Daniel Shedid.

5 recordsLinked to original sources
PubMed2007

Cervical spondylosis anatomy: pathophysiology and biomechanics.

Cervical spondylosis is the most common progressive disorder in the aging cervical spine. It results from the process of degeneration of the intervertebral discs and facet joints of the cervical spine. Biomechanically, the disc and the facets are the connecting structures between the vertebrae for the transmission of external forces. They also facilitate cervical spine mobility. Symptoms related to myelopathy and radiculopathy are caused by the formation of osteophytes, which compromise the diameter of the spinal canal. This compromise may also be partially developmental. The developmental process, together with the degenerative process, may cause mechanical pressure on the spinal cord at one or multiple levels. This pressure may produce direct neurological damage or ischemic changes and, thus, lead to spinal cord disturbances. A thorough understanding of the biomechanics, the pathology, the clinical presentation, the radiological evaluation, as well as the surgical indications of cervical spondylosis, is essential for the management of patients with cervical spondylosis.

Biomechanical Phenomena↗
PubMed2007

Decision making process: problem-based decision making.

Clinical problems are often complex. Problems of great complexity are usually associated with a commensurately greater degree of difficulty with respect to the decision making process. This is most certainly true regarding the management of cervical spondylosis. Usually, clinicians make clinically appropriate decisions. However, more often than realized, suboptimal decisions may be made. Therefore, an assessment of the types of errors regarding clinical decision making are worthy of consideration. In this article, a scheme for decision making regarding the management of cervical spondylosis is presented.

Cervical Vertebrae↗
PubMed2006

Kyphoplasty: vertebral augmentation for compression fractures.

Osteoporosis has devastating consequences for individuals and society in terms of suffering, disability, and increased health care expenses. Early diagnosis and treatment of compression fractures with kyphoplasty allow restoration of normal anatomy as much as possible. Vertebral augmentations by kyphoplasty are efficacious treatments for osteoporotic compression fractures. Kyphoplasty minimizes the risk for cement leakage by compacting the cancellous bone to the periphery, sealing off the fracture clefts,and creating a cavity into which cement is poured. This technique may prevent propagation of further fractures by reducing the col-lapsed vertebral bodies toward its native height, normalizing the sagittal spinal alignment and the force transmission along the spine.

Aged↗
PubMed2002

The expression of rho proteins decreases with human brain tumor progression: potential tumor markers.

Astrocytic tumors are the most common human brain tumors. Establishment of tumor grade is a key determinant both in the choice of a therapeutic approach and in the prognosis. The diagnosis of astrocytic tumors is currently determined following histopathological analysis. The identification of molecular markers would offer a complementary tool for characterizing tumors with respect to their clinical behavior. In this study we determined the expression levels of 3 small GTP binding proteins (RhoA, RhoB and Rac1), of their inhibitor RhoGDI and of caveolin-1 in 24 human astrocytic tumors of grades I to IV. Our results demonstrated that the expression of RhoA and RhoB decreased significantly in all brain tumors studied and was inversely related with tumor of grade II to IV malignancy. The amount of caveolin-1 immunodetected was not significantly different from normal brain samples while the Rac1 expression level was diminished in astrocytic tumors of grades III and IV. Our finding that RhoA and RhoB expression levels are correlated to tumor malignancy suggests that they may serve as novel and efficient diagnostic markers for astrocytic brain tumors of histological grade II to IV and complement currently applied histopathological analysis.

Astrocytoma↗