Biomedical subjects

Dani De Waele

Publications and source records attributed to Dani De Waele.

3 recordsLinked to original sources

PubMed2005

Philosophy of biology: outline of a transcendental project.

This paper analyses the actual meaning of a transcendental philosophy of biology, and does so by exploring and actualising the epistemological and metaphysical value of Kant's viewpoint on living systems. It finds inspiration in the Kantian idea of living systems intrinsically resisting objectification, but critically departs from Kant's philosophical solution in as far as it is based in a subjectivist dogmatism. It attempts to overcome this dogmatism, on the one hand by explicitly taking into account the conditions of possibility at the side of the subject, and on the other hand by embedding both the living and the knowing system into an ontology of complexly organized dynamical systems. This paper fits into the transcendental perspective in acknowledging the need to analyse the conditions of knowability, prior to the contents of what is known. But it also contributes to an expansion and an actualisation of the issue of transcendentality itself by considering the conditions of possibility at the side of the object as intrinsically linked to the conditions of possibility at the side of the subject.

Animals↗

PubMed2002

Epigenetics: a challenge for genetics, evolution, and development?

In this paper, it is argued that differences in how one relates the genome to its surrounding contexts leads to diverse interpretations of the term epigenetics. Three different approaches are considered, ranging from gene-centrism, over gene-regulation, to dynamic systems approaches. Although epigenetics receives its widest interpretation in a systems approach, a paradigmatic shift has taken place in biology from the abandonment of a gene-centric position on to the present. The epistemological and ontological consequences of this shift are made explicit.

Animals↗

PubMed2002

Theories in early embryology: close connections between epigenesis, preformationism, and self-organization.

In current biological and philosophical literature, the use of the terms epigenesis and epigenetics has increased tremendously. As these terms are often confused, this paper aims at clarifying the distinction between them by drawing their conceptual and historical evolutions. The evolution of the term epigenesis is situated in the context of early embryological studies. Departing from Aristotle's natural philosophy, it is shown that epigenesis gained alternating attention from the 17th century onwards, as it was introduced into neo-classical embryology and considered to be the opposite of the preformationist tradition. Where preformation stated that the germ cells of each organism contain preformed miniature adults that unfold during development, epigenesis held that the embryo forms by successive gradual exchanges in an amorphous zygote. Although both traditions tried to explain developmental organization, religious and metaphysical arguments on the conception of embryonic matter as either active or passive determined the scope of their respective explanations. It is shown that these very arguments still underlie the use of gene-centric metaphors in the molecular revolution of the 20th century.

Animals↗