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Biomedical subjects

D de Wied

Publications and source records attributed to D de Wied.

At least 163 records · Page 9Linked to original sources
PubMed1977

Pituitary adrenal system hormones and behaviour.

Neuropeptides related to ACTH, MSH and LPH are involved in acquisition and maintenance of conditioned behaviour. These peptides affect the behaviour by a temporary selective increase in the state of arousal in limbic midbrain structures, thereby increasing the motivational influence of environmental stimuli. Steroids of adrenal origin affect conditioned behaviour in a way opposite to that of ACTH and related peptides. Such steroids alter the arousal level in limbic midbrain structures to enhance discrimination and consequently the elimination of non relevant behaviourla responses. Neuropeptides related to ACTH play a basic role in motivational, learning and memory processes, while the pituitary-adrenal system through the secretion of corticosteroids has a secondary modulationg function.

Adrenocorticotropic Hormone↗
PubMed1976

Changes in excitability of the theta activity generating substrate by ACTH 4-10 in the rat.

The present experiments tested the sensitivity of theta activity to ACTH 4-10 a peptide known to facilitate the maintenance of conditioned behaviors. Hippocampal theta activity was induced by electrical stimulation of the reticular formation in freely moving rats. The administration of ACTH 4-10 produced a typical 0.5 c/s shift indominant frequency and an increase in 7.5-9.0 c/s components of induced theta activity. The effects were maximal between 60-120 min after subcutaneous injection and lasted several hours. The fact, that a similar effect could be obtained by an increase in stimulus intensity suggests an elevated excitability in the theta generating system in the presence of the peptide. The possible significance of this finding for the maintenance of learned behavior is discussed.

Adrenocorticotropic Hormone↗