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Biomedical subjects

D Zauli

Publications and source records attributed to D Zauli.

At least 73 records · Page 4Linked to original sources
PubMed1986

Alopecia areata.

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Adolescent↗
PubMed1985

Relationship between smooth muscle and cytoskeleton antibodies in neuroblastoma.

The previously reported high prevalence of smooth muscle antibodies in neuroblastoma has been found to be associated with a similarly elevated prevalence of anti-cytoskeleton antibodies. The most relevant finding is related to anti-microfilaments (anti-actin) and anti-microtubules antibodies, which were detected with highly significantly different prevalences when compared with a disease control group (p less than 0.001 and p less than 0.000001, respectively). The correspondence between smooth muscle antibodies and anti-cytoskeleton antibodies is incomplete, and it is more relevant for anti-microfilaments. It is concluded that antigen specificities of smooth muscle antibodies in neuroblastoma are as complex as documented in other diseases. Possible pathogenetic and clinical implications emerging from these data are discussed.

Antibodies↗
PubMed1985

Alopecia areata.

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Adolescent↗
PubMed1985

Different course of acute hepatitis B in elderly adults.

A retrospective study on 50 young and 35 aged patients with acute hepatitis B was performed. Clinical and laboratory parameters were evaluated. The most significant results obtained in the aged group when compared with the young were longer hospitalization, less elevated serum glutamic-pyruvic transaminase, serum bilirubin and alkaline phosphatase significantly higher, lower IgM and higher IgA levels. The results indicate that acute hepatitis B in elderly adults is characterized by a milder liver cell necrosis and a hypercholestatic pattern. The possible causes for these features are discussed.

Acute Disease↗
PubMed1985

Antibodies to the cytoskeleton components and other autoantibodies in inflammatory bowel disease.

A high prevalence of antibodies to cytoskeleton components (anti-CYTO) and of anti-smooth muscle (SMA) and antinuclear (ANA) antibodies has been found in inflammatory bowel disease (IBD). In particular, a significant correlation has been documented between anti-CYTO and activity of the disease in ulcerative colitis and anti-fibroblast intermediate filaments (anti-vimentin) antibodies and Crohn's disease. The antibodies are detectable in the three major immunoglobulin classes, including IgA. While titres of anti-CYTO did not exceed 1:40, ANA and SMA were of high titres (up to 1:1,280). Antibodies to epithelial cells intermediate filaments (anti-cytokeratin) were detected only occasionally. The significance of these findings in IBD is discussed.

Adolescent↗
PubMed1985

Non-organ-specific autoimmunity in alopecia.

A significantly high prevalence (41%) of non-organ-specific autoantibodies, tested in immunofluorescence with sera diluted 1:40, is reported in sera from 86 alopecia patients. No correlation was found with extension and duration of the disease, topical treatment with contact agents or response to it. The relevance and significance of these findings, with particular reference to anti-smooth muscle and anti-basal cell layer antibodies, is discussed.

Adolescent↗
PubMed1983

Evaluation of serum rosette inhibitory factors in chronic liver disease.

Serum rosette inhibitory factors (IF) were detected in 61% of 18 sera from HBsAg negative and in 78% of 14 sera from HBsAg positive chronic active liver disease (CALD) patients, who were not under immunosuppressive treatment. In CALD patients, who were under treatment for at least 6 months, IF were detected in 66% of the HBsAg positive patients and only in 18% of the HBsAg negative ones. After precipitation of the serum gamma-globulins by ammonium sulphate, IF were found in the supernatant only in HBsAg positive sera, while completely disappeared in HBsAg negative ones. A significant correlation between serum IF and factors reacting in immunofluorescence (IFL) with a T enriched preparation of lymphocytes was documented only in HBsAg negative cases. No correlation was found between serum IF and circulating immune complexes (IC) or lymphocytotoxins in any of the sera tested. From all these data it is concluded that serum IF detectable in HBsAg negative CALD cases are probably immunoglobulins. Our data would favour the hypothesis that they are anti-T lymphocytes antibodies, since no correlation was found between serum IF and circulating IC. Similar factors, detectable in HBsAg positive sera, are, at least in part, different. The role of such factors in the modulation of the immune response in CALD patients is discussed.

Adolescent↗
PubMed1980

Smooth-muscle antibodies in children with neuroblastoma.

Smooth-muscle antibodies (SMA) were detected in 16 of 18 (89%) children with neuroblastoma and in 43 of 172 (25%) pediatric hospital patients without malignancies. The SMA were mainly of the IgG class. The most common immunofluorescence pattern was SMA-V (vessel) and titers did not exceed 1:160. Absorption and immunodiffusion tests with action (from rabbit skeletal muscle) showed that the SMA associated with neuroblastoma are mainly directed against actin, although different antigen specificities (myosin, meromyosin) are probably involved in some cases. In both chronic active hepatitis and neuroblastoma, SMA would represent a specific response to intracellular contractile proteins (mainly actin) induced by tissue damage. A feedback role in controlling cellular proliferation has been postulated for experimentally raised SMA. This would be relevant in cases of malignancy.

Antibodies↗