Search PubMed⌕ Search

Biomedical subjects

D Y Sue

Publications and source records attributed to D Y Sue.

At least 37 records · Page 2Linked to original sources

The role of exercise testing in impairment evaluation.

To examine the usefulness of exercise testing in impairment evaluation, we reviewed the evaluation of 348 asbestos-exposed shipyard workers. We compared work capacity predicted from history, physical examination, chest roentgenogram, resting electrocardiogram, and resting pulmonary function tests with measured work capacity during an incremental cycle exercise test. The predicted work capacity was often incorrect when compared with measured maximal oxygen uptake (VO2). One third (22 of 66) of those predicted to have reduced work capacity had normal measured work capacity, and 46 of 148 workers (31%) predicted to have normal work capacity were found to have low maximal VO2 during exercise. Of 134 men for whom predicted work capacity was uncertain, maximal VO2 during exercise was low in 49 (37%), normal in 81 (60%), and remained indeterminate in 4 (3%). Thus, of the 138 workers who had low measured VO2, 43 were correctly predicted to have normal work capacity, 46 were incorrectly predicted, and the prediction was uncertain in 49. Only a few were limited by respiratory disease, and cardiovascular disorders limited 69% of those with a low maximal VO2 during exercise. Accordingly, resting VC, FEV1, and DLCO had a poor correlation with exercise performance. Finally, we found that resting DLCO was a poor predictor of abnormal exercise AaPO2, dead-space/tidal volume ratio, or arterial end-tidal PCO2 difference. We conclude that exercise testing is needed for accurate work capacity assessment in impairment evaluation. Exercise testing also facilitates the identification of the major limiting system in those with low work capacity.

Asbestosis↗

Comparison of arterial-end-tidal PCO2 difference and dead space/tidal volume ratio in respiratory failure.

End-tidal CO2 monitors are used to estimate arterial CO2 pressure (PaCO2), but appropriate use of this noninvasive method of assessing blood gases is unclear. In patients with lung disease, the end-tidal CO2 pressure (PETCO2) can differ from PaCO2 because of ventilation-perfusion (VA/Q) mismatching, and changes in PETCO2 may be seen with corresponding increase, decrease, or no change in PaCO2 depending on what happens to VA/Q mismatching. We compared the difference between PETCO2 and PaCO2 in 17 patients undergoing mechanical ventilation. Large differences were found between PaCO2 and PETCO2 in individual patients; P(a-et)CO2 correlated closely with VD/VT. Our studies confirm that PetCO2 is a poor estimate of PaCO2 in patients with respiratory failure. However, the P(a-et)CO2 may be the most appropriate use for end-tidal PCO2 monitoring. In addition, we found that the end-tidal CO2 monitor may be easily adapted for expedient measurement of VD/VT.

Adult↗

Bronchodilatation and attenuation of exercise-induced bronchospasm by PY 108-068, a new calcium antagonist.

The effect of a new dihydropyridine-derivative calcium antagonist, PY 108-068, on resting and postexercise flow rates was evaluated in 12 adult asthmatic subjects in a double-blind, randomized, placebo-controlled, cross-over study. The study consisted of 2 periods, each lasting for 3 days. For a given period a single dose of PY 108-068 (or placebo) was given orally, 75 mg on the first day and 150 mg on the second and third day. Spirometry was obtained at 30-min intervals thereafter. On Day 3, 75 min after the medication was given, a 6-min treadmill exercise test was performed breathing dry air. The mean maximal FEV1 recorded after 150 mg of PY 108-068 on Day 2 was 15 +/- 4% higher than the daily baseline (p less than 0.05), whereas after placebo the maximal FEV1 value was not different from the daily baseline. Also, the mean FEV1 values, expressed as percent of the daily predrug baseline, were significantly higher at 2 and 3 h after 150 mg of PY 108-068 than the respective values after placebo (110 +/- 4 compared with 95 +/- 1, and 106 +/- 5 compared with 91 +/- 3, respectively). Exercise-induced bronchospasm (EIB), expressed as maximal percent fall in FEV1 from preexercise baseline, was attenuated by PY 108-068 as compared with placebo (% delta FEV1 of 20 +/- 6 and 40 +/- 4, respectively; p less than 0.001). Protection against EIB did not correlate with the resting bronchodilation induced by PY 108-068, but was more likely if the patient had eosinophilia. Thus, PY 108-068 not only attenuates EIB but also causes resting bronchodilation, a unique finding for calcium channel blockers.

Adult↗

Comparison of PY 108-068, a new calcium antagonist, with nifedipine in exercise-induced asthma.

Several calcium antagonists, each with significantly different chemical structures, have demonstrated variable attenuation of exercise-induced asthma. Quantitative comparisons have been hampered by differences in the intensity of challenge and the severity of the underlying disease between groups of patients. In 12 asthmatic adults with relatively severe exercise-induced asthma, we compared the effect of a new calcium antagonist, PY 108-068, in doses of 75 mg and 150 mg with nifedipine (30 mg) and placebo on resting flow rates and flow rates after exercise. Over a three-week period, each patient completed a four-day, randomized, double-blind Latin-square study. After receiving one of four oral drugs, spirometry was repeated every 30 minutes for two hours, followed by a six-minute treadmill exercise test breathing dry air. The exercise tests were well matched for work rate, ventilation, heart rate, and oxygen uptake. Spirometry was then repeated seven times over the next 30 minutes after exercise. Though both 150 mg of PY 108-068 and nifedipine were associated with mild bronchodilation before exercise, only the latter was significant (p less than 0.05). Exercise-induced asthma (expressed as maximal percent fall in the forced expiratory volume in one second from before baseline) was significantly attenuated only by 150 mg of PY 108-068 compared to placebo (24 +/- 13 vs 40 +/- 16; p less than 0.05). Headache, which occurred in six subjects after nifedipine, five after 150 mg of PY 108-068, one after 75 mg of PY 108-068, and none after placebo, was subjectively more severe after nifedipine. We conclude that in these patients, there was a tendency for mild bronchodilation before exercise with both 150 mg of PY 108-068 and nifedipine, but only the 150-mg dose provided significant protection against exercise-induced asthma two hours after the drug.

Adolescent↗

Immediate effects of cigarette smoking on cardiorespiratory responses to exercise.

To determine the acute action of cigarette smoking on cardiorespiratory function under stress, the immediate effects of cigarette smoking on the ventilatory, gas exchange, and cardiovascular responses to exercise were studied in nine healthy male subjects. Each subject performed an incremental exercise test to exhaustion on two separate days, one without smoking (control) and one after smoking 3 cigarettes/h for 5 h. The order of the two tests was randomized. Arterial blood gases and pH were measured during rest and all levels of exercise; CO blood levels confirmed the absorption of cigarette smoke. In addition, minute ventilation (VE), end-tidal PCO2 and PO2, O2 uptake (VO2), CO2 production, directly measured blood pressure, electrocardiogram, and heart rate (HR) were recorded every 30 s. The dead space-to-tidal volume ratio (VD/VT), maximal aerobic capacity (VO2max), and anaerobic threshold (AT) were determined from the gas exchange data. Cigarette smoking resulted in a significantly lower VO2max, AT, and VO2/HR (O2 pulse) and a significantly higher HR, pulse-pressure product, and pulse pressure (P less than 0.05) compared with the control. Additionally, a trend toward a higher VD/VT and arterial-end-tidal PCO2 difference was found during exercise after smoking. We conclude that cigarette smoking causes immediate detrimental effects on cardiovascular function during exercise, including tachycardia, increased pulse-pressure product, and impaired O2 delivery. The acute effects on respiratory function were less striking and primarily limited to abnormalities reflecting ventilation-perfusion mismatching.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Lung function and exercise performance in smoking and nonsmoking asbestos-exposed workers.

Evaluation of impairment caused by exposure to an occupational toxin can be complicated by additional exposure to other injurious agents. Because cigarette smoking is common and cigarettes are implicated in obstructive lung disease and cardiovascular diseases, we assessed the contribution of smoking to functional abnormalities in a group of asbestos-exposed shipyard workers. Seventy-three workers who never smoked were paired with 73 current smokers by age and asbestos exposure. Pulmonary function and performance during cycle incremental exercise were compared between the 2 groups. Nonsmokers had significantly higher VC, FEV1, FEV1/VC, and diffusing capacity for carbon monoxide than did smokers. Only 3 of the 73 nonsmokers but 23 of the 73 smokers had a FEV1/VC below the 95% confidence limit of predicted value. The FEF25-75%, on the other hand, failed to identify additional subjects with obstruction not found by the FEV1/VC. During exercise, despite no difference in maximal heart rate, the maximal O2 uptake (VO2max) and oxygen-pulse were lower among smokers. In addition, smokers more frequently had abnormal AaPO2 at maximal exercise. Of 33 smokers who had a VO2max less than 80% of predicted, 16 were judged to have cardiac disease, whereas only 2 appeared to be limited by obstruction. Only 15 of the 73 nonsmokers had a VO2max less than 80%. We conclude that cigarette smoking was the major contributing factor to the obstructive lung disease observed in asbestos workers, and it also had a strong influence on the occurrence, nature, and magnitude of exercise limitation. The history of cigarette smoking has an important effect on the assessment of impairment from asbestos.

Aged↗

Predicted values for clinical exercise testing.

Following thorough evaluation at rest, 265 of 400 current or ex-shipyard workers rode a cycle ergometer with equal work increments each minute to exhaustion while continuous multiple noninvasive cardiorespiratory measures and intermittent intra-arterial blood pressure and blood gas measures were made. Seventy-seven men, with a mean age of 54, including some who were smokers, obese, or hypertensive, were judged to have normal cardiorespiratory systems based on history, physical, electrocardiogram during rest and exercise, chest X-ray, pulmonary function tests, and exercise performance. Their responses to exercise are given. It was unusual to find at maximal exercise a breathing reserve less than 11 L/min, arterial PO2 less than 80 mm Hg, alveolar-arterial PO2 difference greater than 38 mm Hg, arterial-end tidal PCO2 difference greater than 1 mm Hg, respiratory frequency greater than 60, or a dead space/tidal volume ratio greater than 0.28. The normal anaerobic threshold/maximal O2 uptake ratio exceeded 40%. With maximal exercise, the intra-arterial systolic and diastolic pressures rose an average of 68 and 13 mm Hg, respectively. For predicting maximal oxygen uptake and oxygen pulse in an overweight man, we find it preferable to use age and height rather than age and weight.

Adult↗

Normal values in adults during exercise testing.

The cardiopulmonary response to 1-minute incremental cycle exercise in a population of 77 sedentary middle-aged men provides an opportunity to develop typical values that may prove useful in assessing impairment and disease. Maximal oxygen uptake can be predicted from age and height, using standard predicting formulas. Patterns of change in ventilation, anaerobic threshold, heart rate, oxygen pulse, and arterial blood gases during exercise are similar to those previously reported, although the magnitude of changes may be different.

Body Weight↗

Exercise gas exchange in asthmatics after beta-adrenergic blockade.

Pharmacologic beta-adrenergic blockade reduces maximal heart rate (HR) during exercise but variable results have been reported for minute ventilation (VE), CO2 output (VCO2), and O2 uptake (VO2). A total group of 19 subjects with mild asthma was studied. We studied 16 subjects from the group who received placebo or pindolol, a beta-adrenergic antagonist, during 1-min incremental exercise on a cycle ergometer. During incremental exercise, HR, VE, VCO2, and VO2 were less after beta-blockade than after placebo at the same work rate below the anaerobic threshold. Maximal HR, VE, VO2, VCO2, and work rate were significantly less after beta-blockade. In addition, we studied six subjects from the group, including three who had also performed incremental exercise, during the steady state of constant-work cycling exercise. We found no difference in VE, VCO2, or VO2 although HR was less after beta-blockade. We conclude that beta-adrenergic blockade affects gas exchange by delaying the normal cardiovascular response to exercise. Decreased VE during incremental exercise is due to slowed delivery of CO2 load to the lungs rather than alterations in substrate, lung function, or ventilatory control.

Adolescent↗

Optimizing the exercise protocol for cardiopulmonary assessment.

Twelve normal men performed 1-min incremental exercise tests to exhaustion in approximately 10 min on both treadmill and cycle ergometer. The maximal O2 uptake (VO2 max) and anaerobic threshold (AT) were higher (6 and 13%, respectively) on the treadmill than the cycle; the AT was reached at about 50% of VO2 max on both ergometers. Maximal CO2 output, heart rate, and O2 pulse were also slightly, but significantly higher on the treadmill. Maximal ventilation, gas exchange ratio, and ventilatory equivalents for O2 and CO2 for both forms of exercise were not significantly different. To determine the optimum exercise test for both treadmill and cycle, we exercised five of the subjects at various work rate increments on both ergometers in a randomized design. The treadmill increments were 0.8, 1.7, 2.5, and 4.2%/min at a constant speed of 3.4 mph, and 1.7 and 4.2%/min at 4.5 mph. Cycle increments were 15, 30, and 60 W/min. The VO2 max was significantly higher on tests where the increment magnitude was large enough to induce test durations of 8-17 min, but the AT was independent of test duration. Thus, for evaluating cardiopulmonary function with incremental exercise testing by either treadmill or cycle, we suggest selecting a work rate increment to bring the subject to the limit of his tolerance in about 10 min.

Adult↗

Effects of obesity on respiratory function.

Obesity, because it alters the relationship between the lungs, chest wall, and diaphragm, has been expected to alter respiratory function. We studied 43 massively obese but otherwise normal, nonsmoking, young adults with spirometry, lung volume measurement by nitrogen washout, and single-breath diffusing capacity for carbon monoxide (DLCO). Changes in respiratory function were of two types, those that changed in proportion to degree of obesity--expiratory reserve volume (ERV) and DLCO--and those that changed only with extreme obesity--vital capacity, total lung capacity, and maximal voluntary ventilation. When compared with commonly used predicting equations, we found that mean values of subjects grouped by degree of obesity were very close to predicted values, except in those with extreme obesity in whom weight (kg)/height (cm) exceeded 1.0. In 29 subjects who lost a mean of 56 kg, significant increases in vital capacity, ERV, and maximal voluntary ventilation were found, along with a significant decrease in DLCO. Because most subjects fell within the generally accepted 95% confidence limits for the predicted values, we concluded that obesity does not usually preclude use of usual predictors. An abnormal pulmonary function test value should be considered as caused by intrinsic lung disease and not by obesity, except in those with extreme obesity.

Adult↗

The value of exercise in testing beta blockade and airway reactivity in asthmatic patients.

On separate days, in double-blind fashion, 23 subjects with mild or moderate asthma were injected intravenously with a placebo or 0.4 mg pindolol. Plethysmographic and spirometric measurements were performed before and after injection and repeatedly after exhausting incremental bicycle ergometer exercise. The mean reduction in maximal exercise heart rate of 26 bpm after pindolol compared to placebo confirmed significant cardiovascular beta blockade. Baseline 1-second vital capacity (FEV1) values and other flow rates were similar in both trials. There were similar reductions in FEV1 (median of 1% to 2% and mean of 3% to 5%) and other flow rates immediately after injection of placebo or pindolol. Exercise-induced bronchospasm (EIB) occurred in 34 of 46 trials and tended to be more severe in subjects with more baseline airway obstruction. Minimal EIB (FEV1 to 80% to 90% of baseline values) developed in eight after taking placebo and in seven after taking pindolol; mild EIB (FEV1 to 60% to 79% of baseline) developed in the five after placebo and six after pindolol and moderate EIB (FEV1 to 40% to 59% of baseline) developed in three after placebo and five after pindolol. In five subjects, FEV1 was reduced to a greater extent after placebo than after pindolol (median of 6%), whereas in 13 subjects, FEV1 was reduced to a greater extent after pindolol than after placebo (median of 10%). These small differences in FEV1 between placebo and pindolol were significant by the t test after exercise but not before exercise. Thus, exercise appears to increase the sensitivity in evaluating airway reactivity in asthmatic patients and also tests the effectiveness of cardiovascular beta blockade.

Adolescent↗

Retention of catheter fragment after thoracentesis: report of two cases.

In the two cases presented here, retention of a portion of a plastic catheter in the pleural space occurred during thoracentesis. In both cases, the catheter was probably sheared off by the sharp beveled tip of the metal needle used to introduce the catheter. In one case, the retained catheter was removed during limited thoracotomy with local anesthesia. In the other case, attempts to remove the retained catheter during thoracentesis were unsuccessful, and no furather attempts were made. This complication of thoracentesis can be avoided by paying strict attention to the proper technique for insertion and withdrawal of the needle and the catheter.

Aged↗

Comparison of physiologic dead space/tidal volume ratio and alveolar-arterial PO2 difference during incremental and constant work exercise.

We prefer 1-min incremental exercise testing on a cycle ergometer rather than constant work studies because of its speed, repeatability, and ease of identification of the anaerobic threshold. Although values such as VO2 and anaerobic threshold from both types of studies are reported to be comparable, we questioned whether VD/VT and AaPO2, which depend on simultaneous arterial blood and mixed expired gas sampling, would also be reliable during incremental testing. In 23 patients we did both a constant work test at below the anaerobic threshold and a 1-min incremental test. At matched VO2 we found no difference between VD/VT and AaPO2 despite anticipated differences in VE, VCO2, and R because of differences in their rates of increase. We conclude that VD/VT and AaPO2, determined during 1-min incremental exercise tests, are equivalent to those from constant work tests and that a separate constant work study is not needed for these measurements if determined below the anaerobic threshold.

Adult↗

beta-Adrenergic blockade with pindolol (LB-46) in mild to moderate asthma.

Beta-adrenergic blockade may be hazardous in asthma and chronic obstructive lung disease. The beta-adrenergic antagonist pindolol (LB-46) has been suggested to be more tolerable in such patients. We gave intravenously both 0.4 mg pindolol and placebo to 24 mild to moderate asthmatic subjects in remission. In 23 subjects who completed the study, there was no significant difference in pulmonary function between the pindolol and placebo trials either after drug administration or following exhausting exercise after drug administration, although a trend toward reduced pulmonary function after pindolol was seen. Significant differences (P less than 0.05) were found after inhaled isoproterenol when FEV1 and peak expiratory flow rates were compared. We conclude that in this group of mild to moderate asthmatic subjects, there was no adverse effect from pindolol even during exercise-induced bronchospasm. The response to isoproterenol may have been slightly impaired, but the clinical meaning of this is unclear.

Adolescent↗

Measurement and analysis of gas exchange during exercise using a programmable calculator.

Although exercise testing is useful in the diagnosis and management of cardiovascular and pulmonary diseases, a rapid comprehensive method for measurement of ventilation and gas exchange has been limited to expensive complex computer-based systems. We devised a relatively inexpensive, technically simple, and clinically oriented exercise system built around a desktop calculator. This system automatically collects and analyzes data on a breath-by-breath basis. Our calculator system overcomes the potential inaccuracies of gas exchange measurement due to water vapor dilution and mismatching of expired flow and gas concentrations. We found no difference between the calculator-derived minute ventilation, CO2 production, O2 consumption, and respiratory exchange ratio and the values determined from simultaneous mixed expired gas collections in 30 constant-work-rate exercise studies. Both tabular and graphic displays of minute ventilation, CO2 production, O2 consumption, respiratory exchange ratio, heart rate, end-tidal O2 tension, end-tidal CO2 tension, and arterial blood gas value are included for aid in the interpretation of clinical exercise tests.

Carbon Dioxide↗

Colon polyps, sebaceous cysts, gastric polyps, and malignant brain tumor in a family.

A unique family with a distinct syndrome of adenomatous colonic polyps and sebaceous cysts without osseous or soft tissue abnormalities is presented. One member had benign gastric polyps limited to the upper half of the stomach and another had a medulloblastoma of the cerebellum. A histologic feature in the colon of the propositus was the presence of atypical epithelium in flat mucosa as well as in the colonic polyps.

Adolescent↗