Search PubMed⌕ Search

Biomedical subjects

D Wright

Publications and source records attributed to D Wright.

At least 145 records · Page 8Linked to original sources
PubMed1995

Recruiting for success--the potential for using occupational personality questionnaires for the assessment of doctors.

OBJECTIVES: to evaluate the Saville and Holdsworth Occupational Personality Questionnaire (OPQ) to assess its potential and validity as a tool in the recruitment of doctors. To determine the range of personality characteristics in a group of general practitioners. DESIGN: an administered commercially available questionnaire. SETTING: general practitioners in North and Mid. Stafftordshire. SUBJECTS: 133 general practitioners or trainees. RESULTS: 44% of general practitioners agreed to participate. The majority found it useful and recognised its potential to increase self-awareness, highlight weaknesses that might be improved and for future recruitment of others to their teams. Doctors' personality traits were similar to those of managerial/professional norms. The validity of the OPQ was supported by (a) significant associations with subjects' previously reported mental health problems and (b) 83% of respondents confirming that their reports correctly described their personalities at work. CONCLUSIONS: OPQs have a place in the recruitment of doctors by identifying appropriate people to strengthen the team.

England↗
PubMed1995

Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations.

The normal counterpart of the neoplastic B cells occurring in Burkitt's lymphomas (BL) is an issue of controversial debate. To clarify this matter, a semi-nested primer polymerase chain reaction was performed to amplify the VDJ rearrangements of the immunoglobulin heavy chain (VH) gene of DNA extracts from 10 (8 sporadic and 2 endemic) BL cases. The resulting amplificates were sequenced for comparison with known germ line VH segments. The control cases comprised six cases of B cell chronic lymphocytic leukemia and six cases of mantle cell lymphoma known to display naive nonmutated, ie, pre-germinal center VH configurations; and eight cases of follicular center lymphoma known to display mutated VH genes with signs of a still-ongoing mutation reaction, characteristic for germinal center cells and lymphomas that derive therefrom. The results of this approach revealed that both sporadic and endemic BL express mutated VH genes with a mutation frequency considerably lower (4.9% and 5.4%, respectively) than that observed in follicular center lymphoma (11.8%). In addition, after subcloning the amplificates, sequence analysis revealed no signs of ongoing mutations. These results led us to conclude that the derivation of neoplastic B cells in BL is definitely not from naive, nonmutated pre-germinal center B cells. Instead, our findings support the view that BL cells stem either from early centroblasts that are arrested after an initial hypermutation reaction, or from germinal center B cells that have differentiated in terms of surface immunoglobulin profile and mutation pattern but not in terms of morphology and proliferation toward SIgM+ IgD- memory B cells because of the deregulated c-myc gene expression.

Burkitt Lymphoma↗
PubMed1995

The application of an anthropometric database of elderly and disabled people.

We report on the development of an anthropometric database of elderly and disabled people for use by designers. The problems encountered by the designer in developing products for the elderly and disabled are highlighted. Reference is made to previous work carried out using computer modelling to simulate the human product interface, and the problems in specifying the anthropometric data are discussed. From a review of existing anthropometric databases we have noted the lack of data on the elderly and disabled. Not only is there insufficient dynamic anthropometric data available, but there are no standards for the measurement techniques to produce this data. We report briefly on parallel work by the group which is looking at anthropometric measurement techniques, and the computer modelling of the human product interface for elderly and disabled people. The lack of dynamic anthropometric data that is appropriate for use by designers and rehabilitation engineers is the major area to be addressed by the database. We investigate the use of existing medical data available as a possible solution to the problem. The database will also seek to address the problem through its methodology of interpretation and presentation.

Aged↗
PubMed1995

Techniques in anthropometry applied to disabled and elderly populations.

We discuss the requirements of anthropometric and biomechanical data for specific application to the design of assistive devices and other products for elderly and disabled populations, including body size, shape, range of motion and strength data. We analyse available information and the practical and statistical problems involved in the collection of data from such populations. We comment on the different human interface design issues posed by various types of device and compare a task-specific approach to ergonomic analysis with the use of a generic biomechanical database. The specific requirements of a useful biomechanical data collection system intended to fulfil this need, and the conditions under which a practical system would have to operate are discussed. We review a range of available measurement techniques, including manual, mechanical, optical and electronic systems and discuss their relative fitness for the task in question. We propose an approach to the collection of multi-variable biomechanical data from the analysis of various tasks and discuss the use of computer models and other means of interpreting such data to make it available to product designers and engineers.

Aged↗
PubMed1994

The epidemiology of forestry work-related injuries in New Zealand, 1975-88: fatalities and hospitalisations.

AIM: This paper presents a detailed investigation of the injury experience of New Zealand forestry workers, including loggers and silviculture workers. METHODS: Record linkage of multiple data sources. RESULTS: During the period 1975-88, there were 81 work-related fatalities among loggers and 10 fatalities among silviculture workers, yielding fatality rates of 2.03 and 0.15 per 1000 workers/year, respectively. These figures were substantially higher than the fatal injury rate among the overall New Zealand workforce of 0.07 deaths per 1000 workers/year. In addition there were 1068 work-related injuries resulting in hospitalisation among loggers, and 478 among silviculture workers, yielding hospitalisation rates of 38.93 and 9.58 per 1000 workers/year, respectively. The types of injury contact involved in each incident were analysed. Contact with falling trees was the leading cause of death in forestry, accounting for over half of the fatal injuries among loggers and a third among silviculture workers. For loggers, the three commonest types of contact resulting in hospitalisation were: chainsaw injuries (n = 351; 33%), falling trees (n = 269; 25%), and rolling logs (n = 82; 8%). Among silviculture workers, the three commonest types of contact resulting in hospitalisation were: chainsaw injuries (n = 108; 23%), falling trees (n = 96; 20%), and falls/slips and trips (n = 94; 20%) CONCLUSION: There is clear need for continued efforts to improve the overall safety of forestry work in New Zealand.

Accidents, Occupational↗
PubMed1994

Hernia repair.

Explore the source record for details and available documents.

Hernia, Inguinal↗
PubMed1994

An economic evaluation of the introduction of vaccination against hepatitis A in a peacekeeping operation. The case of the United Nations Protection Force in Yugoslavia.

The costs and benefits of vaccinating troops on United Nations tours in Yugoslavia against hepatitis A were compared. The marginal cost of one case of hepatitis A avoided by vaccination was calculated and compared with the marginal cost of achieving the same outcome by passive immunization. The cost-benefit ratio (medium estimate) for troops at low risk of contracting hepatitis A was 0.01 and for those at high risk was 0.03. Vaccinating troops against hepatitis A for a single deployment appears to be an inefficient procedure, especially in troops at low risk. However, in professional troops from countries of low hepatitis A endemicity who are likely to be involved in several operational deployments, vaccination becomes more efficient the more times the same troops are deployed.

Cost-Benefit Analysis↗
PubMed1994

The role of the pre-symptomatic food handler in a common source outbreak of food-borne SRSV gastroenteritis in a group of hospitals.

A common source outbreak of small round structure virus (SRSV) gastroenteritis affected 81 patients and 114 staff in four hospitals served by one central hospital kitchen. Eating salad items was found to be significantly associated with illness. In a cohort study of a staff buffet function eating turkey salad sandwiches was associated with illness (relative risk = 2.4; 95% CI = 1.4-4.1; P = 0.003), and a case control study of patients in one hospital showed an odds ratio of 6.6 (95% CI = 1.0-71.6; P = 0.04) for eating tuna salad and becoming ill. One of two food handlers who prepared the salads became ill the day following food preparation; she also had a young child at home who had been ill with a gastrointestinal illness during the previous two days. Contamination of food by mechanical transmission of the virus from the child via clothes and hands of the mother, or pre-symptomatic faecal excretion in the mother are possible explanations of contamination of food.

Caliciviridae Infections↗
PubMed1994

Automatic recording and timing of defibrillation on general wards by day and night.

To measure the speed of response to ventricular fibrillation on general medical wards and to assess the importance of this and other factors for survival to leave hospital, 69 consecutive patients with ventricular fibrillation were studied prospectively using an automatic timing device in the hospital telephone exchange and an automatic timer and ECG recording during resuscitation. Twenty-seven patients were initially resuscitated and 17 were discharged from hospital. The median time to connect the monitor after recognition of a cardiac arrest was 127 s (range 0-277) for survivors and 132.5 s (range 0-620) for non-survivors. The median time ventricular fibrillation was displayed before the first shock was 43 s (range 4-75) for survivors and 52 s (range 10-454) for non-survivors. These differences were not significant; but logistic regression analysis identified primary ventricular fibrillation, short display time (logged data), 'early' time of day, absence of pre-existing non-cardiac illness, and post-defibrillation heart-rate > 30 beats.min-1 in rank order as independent predictors of survival. In spite of no significant diurnal variation in response time, successful resuscitations were concentrated in the early nursing shift (0730-1530 h). Four shocks were inappropriate. Clinical diagnosis was more predictive of outcome than the time to the first shock. The reasons for the poorer results in the evening and night are uncertain.

Aged↗
PubMed1994

Peripheral stem cell transplantation.

Peripheral stem cell transplantation (PSCT) affords many cancer patients the opportunity to use their own blood cells to recover from ablative chemotherapy. Bone marrow transplantation (BMT) also affords cancer patients this same opportunity; however, more problems are associated with this treatment. Medical-surgical nurses caring for patients receiving these innovations must be aware of current care guidelines.

Blood Component Transfusion↗
PubMed1993

Methylphosphate cap structure increases the stability of 7SK, B2 and U6 small RNAs in Xenopus oocytes.

We studied the role of the methylphosphate cap structure in the stability and nucleocytoplasmic transport by microinjecting U6, 7SK and B2 RNAs into the Xenopus oocytes. In every case, the methylphosphate capped RNAs were 3 to 9 times more stable than the uncapped RNAs. When a methylphosphate cap structure was placed on human H1 RNA which is normally not capped, its stability was improved 2-7 fold. These data show that the methylphosphate cap enhances the stability of 7SK, B2, H1 and U6 RNAs. The methylphosphate-capped 7SK RNA was transported into the nucleus from cytoplasm, but remained in the nucleus when injected into the nucleus; in this respect, 7SK RNA exhibited properties previously shown for U6 RNA. Both U6 and 7SK RNAs with ppp on their 5' ends were transported from cytoplasm to the nucleus suggesting that the methylphosphate cap structure is not required for transport of these RNAs across the nuclear membrane.

Animals↗
PubMed1993

Development of a fatigue scale.

A self-rating scale was developed to measure the severity of fatigue. Two-hundred and seventy-four new registrations on a general practice list completed a 14-item fatigue scale. In addition, 100 consecutive attenders to a general practice completed the fatigue scale and the fatigue item of the revised Clinical Interview Schedule (CIS-R). These were compared by the application of Relative Operating Characteristic (ROC) analysis. Tests of internal consistency and principal components analyses were performed on both sets of data. The scale was found to be both reliable and valid. There was a high degree of internal consistency, and the principal components analysis supported the notion of a two-factor solution (physical and mental fatigue). The validation coefficients for the fatigue scale, using an arbitrary cut off score of 3/4 and the item on the CIS-R were: sensitivity 75.5 and specificity 74.5.

Adult↗