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Biomedical subjects

D Winter

Publications and source records attributed to D Winter.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Arterial embolization for Dieulafoy bleeding.

BACKGROUND: Dieulafoy's lesion is a rare cause of gastrointestinal haemorrhage. It has traditionally been treated either endoscopically or with open surgery. AIM: To describe a case treated by arterial embolization. RESULTS: Initially the patient was embolized with Gelfoam pledgets but re-bled at 7 days, the procedure was repeated with fibre coils, there was no further bleeding. CONCLUSION: Arterial embolization is being used increasingly as a first line of treatment as it is fast and minimally invasive with few complications.

Aged↗
PubMedDate not supplied

The perception of problem drinkers by general hospital staff, general practitioners and alcoholic patients.

A sample of 275 subjects (general hospital staff, general practitioners and alcoholic patients) was investigated regarding their perception of problem-drinkers. A set of semantic differential scales was used, and subjects were asked to evaluate the concepts of "problem drinker," "self" and "ideal self." Psychological distance was measured in terms of bipolar personality constructs between each of the above concepts. Significant differences were found between the groups in terms of concept evaluation and psychological distance. The implications of these findings for both research and treatment are discussed.

Alcoholism↗
PubMedDate not supplied

Rapid responses to aldosterone in human distal colon.

Aldosterone at normal physiological levels induces rapid increases in intracellular calcium and pH in human distal colon. The end target of these rapid signaling responses are basolateral K+ channels. Using spectrofluorescence microscopy and Ussing chamber techniques, we have shown that aldosterone activates basolateral Na/H exchange via a protein kinase C and calcium-dependent signaling pathway. The resultant intracellular alkalinization up-regulates an adenosine triphosphate (ATP)-dependent K+ channel (K(ATP)) and inhibits a Ca2+ -dependent K+ channel (K(Ca)). In Ussing chamber experiments, we have shown that the K(ATP) channel is required to drive sodium absorption, whereas the K(Ca) channel is necessary for both cyclic adenosine monophosphate and calcium-dependent chloride secretion. The rapid effects of aldosterone on intracellular calcium, pH, protein kinase C and K(ATP), K(Ca) channels are insensitive to cycloheximide, actinomycin D, and spironalactone, indicating a nongenomic mechanism of action. We propose that the physiological role for the rapid nongenomic effect of aldosterone is to prime pluripotential epithelia for absorption by simultaneously up-regulating K(ATP) channels to drive absorption through surface cells and down-regulating the secretory capacity by inhibiting K(Ca) channels involved in secretion through crypt cells.

Aldosterone↗