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Biomedical subjects

D Willard

Publications and source records attributed to D Willard.

At least 91 records · Page 5Linked to original sources

[Visual future of prematures].

The retinal periphery of 60 premature children now between 5 and 8 years of age and with a weight at birth equal or less than 1,500 g has been investigated. In 20% of these children, pigmentary modifications were noted which were often associated with chorioretinal atrophy. Polymorphic vascular abnormalities were seen in 14% of the cases, i.e. sinuous vessels of irregular caliber or neovascularization. Abnormalities of the vitreous body were also noted in 12% of the patients with glial bags on the periphery and sometimes potentially dangerous tractions folds (4%). All these abnormalities could cause complications such as retinal tear, retinoschisis or retinal detachment. Even if these signs are discrete, they can later on be the source of complications. Refraction studies revealed 30% of myopic children. The most important group had myopias equal or higher than 8 d. The characteristics of the myopia of premature children are its constancy (all premature children are myopic at birth); its importance (it depends on birth weight and on the severity of the retinopathy), and its evolution (the myopia of premature children does not evolve or evolves very slightly).

Birth Weight↗

[Retinal dysplasia with hydrocephalus (author's transl)].

A Study is described of a family in which four children of the same generation died during early childhood; three of them had an obvious hydrocephalus. Two of the latter could be examined clinically, and their eyes removed for pathology. One of them presented clinically bilateral leucocoria; histology showed a total detachment of a dysplastic retina, with absence of development of the vitreous. The other child had apparently normal eyes. Yet on microscopical examination there was a discrete retinal dysplasia without retinal detachment in both eyes, and a persistent hyaloid artery, in one. This association of hydrocephalus with retinal dysplasia is clinically and genetically different from other types of retinal dysplasia.

Abnormalities, Multiple↗

[Neo-natal neutropenia induced by anti-NA 2 allo-immunization. Serological and clinical study of 2 cases in a family].

A severe neutropenia in a 2 day old newborn drew attention to anti-HLA and NA 2 antigranulocytic antibodies in the maternal serum. Close supervision from birth of a younger sibling demonstrated a neutropenia on the 5th day of life. Serological investigation showed the anti-NA 2 antibody to be responsible in both cases. A good result with total blood replacement of leucocyte-free blood in the second case would advocate this treatment in cases of severe immunological neutropenia.

Agranulocytosis↗

A long term evaluation of infants who received a beta-mimetic drug while in utero.

The administration of beta-mimetic drugs to pregnant women poses the problem of possible long-term repercussions in the children born to these mothers. 42 children from women who had been treated with 60-80 mg a day of ritodrine hydrochloride (Pre-par), during a period varying from 3 to 93 days, were closely matched with infants from untreated mothers. Each child, (aged from one to 3 years), was fully investigated on the basis of: a detailed questionnaire to the mother; careful clinical examination; assessment of psychomotor development; the Denver test; electrocardiography and urine analysis. There was no statistically significant difference between the two groups for any of the variables of development that were studied. One child had left ventricular hypertrophy, which was probably incidental. It is concluded that administration of ritodrine hydrochloride to pregnant women induces no harmful long-term effects in their offspring.

Body Height↗

[Severe hyperosmolarity caused by dietary error in the newborn. A disorder of particular concern in migrants].

Hyperosmolarity as a result of dietary error is a fairly common condition. It is more grave than "thirst fever", the benign reputation of which should not be taken too lightly. The consequences may be serious: death or sequelae related to vascular thrombosis or cerebral lesions. Prevention should be possible in most instances as long as obstetricians, paediatricians, midwives and nursery nurses are aware of the danger of overconcentrated milk formula. Its treatment remains fraught with hazard.

Animals↗

[Hemodynamic consequences of umbilical arterial catheterization. Photoplethysmographic study].

The hemodynamic consequences of umbilical arterial infusions in newborns can be registered by photoplethysmography. Thirty-nine children were observed according to the same protocol: it was possible to recognize, on the side of the infusion, without other clinical symptoms, very early but after different times: - in 3 cases, the supression of arteriolar oscillations, back to normal after 24 hours in one case, and after several weeks in 2 cases; - in 2 cases, a transitory increase of arteriolar oscillations; - in 7 cases, an elective decrease of the arteriolar systolic pressure, with unchanged diastolic pressure. In 4/7 cases, it became normal in less than 3 days; - in 3 cases, a decrease in arteriolar systolic and diastolic pressures, during 2 days.

Catheterization↗

[Induced hyperglycemia and its relationship to underweight fetuses: study on a newborn infant].

A study was carried out on hyperglycaemia induced by intravenous administration of glucose between the 1st and 4th day of life in healthy new-born infants and in underweight newborns. The blood glucose level in underweight infants is slightly lower than that in healthy new-born infants. The level of insulin in the blood is much lower in the underweight child after 30 minutes. Although the levels of insulin and Glucagon in the blood vary between the two groups the ratio of Glucagon to insulin is constant and evolves constantly. The ratio is higher the more underweight the child is. It is possible that this can help to maintain the level of blood glucose sufficiently high in the underweight new-born infant.

Birth Weight↗