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Biomedical subjects

D Willard

Publications and source records attributed to D Willard.

At least 55 records · Page 3Linked to original sources
PubMed1988

Pharmacokinetics of teicoplanin in children.

A single dose of 6 mg/kg teicoplanin was infused over 10 min in six children of mean age 7 years, and a single dose of 6 mg/kg was infused over 20 min in four neonates of mean age 8.5 days. Serum sampling was performed at 0 and 10 min and at 1, 4, 12 and 24 h and thereafter 24-hourly, up to ten days. Urine was collected for each 24 h throughout the study in children. Teicoplanin was assayed by high performance liquid chromatography. Tolerability of teicoplanin was excellent both in children and in neonates. For all the patients the serum concentrations of teicoplanin followed an open two-compartment model. Mean Cmax was 48.6 +/- 16.7 mg/l (10 min) in children, and 19.6 +/- 1.05 mg/l (20 min) in neonates, and mean t1/2 beta was 20.5 +/- 5.5 h and 30.3 +/- 6.3 h, respectively. On the basis of the results dosage recommendations for children and neonates are made.

Adolescent↗
PubMed1988

[Diagnosis of double aortic arch in the neonatal period. Contribution of magnetic resonance imaging. Apropos of a case].

The authors report a case of double aortic arch in the newborn (age: 1 month) explored with magnetic resonance imaging. MRI offers a non invasive and non ionizing examination very well-tolerated by the patient if a correct methodology is used (total acquisition time 40 mn). The quality of the images is sufficient for diagnosis and presurgical evaluation: the diameter, the permeability and the relationship with the surrounding organs of the respective aortic arches were well demonstrated with this technique. The contributions of MRI with respect to 2-D echocardiography and angiography as well as the future possible totally non invasive evaluation of this cardiac anomaly is discussed.

Aorta, Thoracic↗
PubMed1987

[The transfer of newborn infants. Experience of a department of neonatology].

The results of 6 years of neonatal transport to the neonatology unit of the Hautepierre hospital (January, 1980 to December, 1985) are reported. During that period 1866 neonates were transferred from maternities of Strasbourg and its region to the neonatology unit, representing 23.77% of total admissions. The 350 premature babies born before or at 32 weeks of pregnancy amount to 55% of babies born at the same gestational age. Mortality in that group (46.52%) was associated mainly with hyaline membrane disease and intraventricular haemorrhage. Neonatal infections and congenital malformations were seen in children born after 32 weeks. To improve the quality of transport and reduce morbidity and mortality, the biological and haemodynamic parameters of the neonates should be stabilized prior to their transfer, and all the necessary precautions (i.e. ventilation, oxygenation, temperature, glycaemia, asepsis) should be observed at every stage of their journey. In high-risk pregnancies, "transfer in utero" to a neonatal intensive care unit undoubtedly is the best solution.

Evaluation Studies as Topic↗
PubMed1987

[Persistent hyperbilirubinemia after intrauterine intraperitoneal transfusions in 4 newborn infants. Role of intraperitoneal red cells present at birth].

Four neonates who had undergone intra-uterine peritoneal blood transfusions for Rhesus disease and hydrops fetalis presented, during the first days of life, with intractable hyperbilirubinemia in spite of multiple exchange transfusions. The hyperbilirubinemia was due to delayed absorption and hemolysis of peritoneal red cells. This unusual complication can be successfully managed with peritoneal lavage which should be performed when the antenatal history is contributive for low absorption of transfused blood.

Blood Transfusion, Intrauterine↗
PubMed1987

Evaluation of single sensor transcutaneous measurement of PO2 and PCO2 in the neonate.

A single combined transcutaneous sensor for PO2 and PCO2 was evaluated in a neonatal intensive care unit. The values obtained with the combined sensor were compared with the values obtained with two separate electrodes monitoring respectively PO2 and PCO2. Adequate correlations were found. The combined sensor represents an improvement on individual electrodes as it spares available skin surface and needs less handling.

Blood Gas Monitoring, Transcutaneous↗
PubMed1987

[Chickenpox and pregnancy. Perinatal aspects and prevention].

Five neonates born to women who had had varicella late in pregnancy or in the post-partum were admitted to our unit during the last year. In utero transmission of varicella-zoster virus occurred in 2 cases. One of them had no clinical eruption but specific IgM at a titer of 1/200. The mother presented with varicella 15 days before delivery. The other developed severe neonatal congenital varicella (with disseminated eruption, pneumonia and seizures). She was treated by Aciclovir (15 mg/kg/8 h). The mother presented with chickenpox 24 hours after birth. Varicella occurring in a pregnant woman from 4 days before to 2 days after delivery is dangerous because the baby will lack maternal antibodies. It may develop severe neonatal varicella (mortality: 20-30%). A neonate in critical condition was successfully given a prophylactic treatment by Aciclovir IV (15 mg/kg/8 h for 5 days) and varicella-zona immunoglobulins (2 ml on days 1, 2, 3). This approach may be the best treatment for babies at risk for severe neonatal varicella.

Chickenpox↗
PubMed1986

Evolution of the visual prognosis of prematures in the last 20 years.

Ophthalmoscopic examinations were performed on 5678 prematures, born between 1964 and 1984, by the same investigator in the same neonatal care unit. Three periods can be differentiated. In the first period (1964-1970) retinal disorders were frequent (20%), a quarter of them severe (stages 3-5). The inspiratory fraction of oxygen was the only oxymetric factor that was monitored. In the second period (1970-1977), less severe forms were observed, but still 4.5% of stage 1 and 8.7% of stage 2 (mild forms) were assessed. During this period, oxygen partial pressure was measured every 6 h in arterial blood whenever the inspiratory fraction of oxygen exceeded 0.3. In the last period (1977-1984), no severe forms were observed and mild forms amounted to only 0.9%. In this period, oxygen partial pressure was continuously monitored transcutaneously, whenever the inspiratory fraction of oxygen exceeded 0.21. Such data show that there is an association between better oxygen monitoring and the dramatically reduced incidence of retinopathy in prematures (RP).

Humans↗
PubMed1986

Role of prenatal genetic counseling before amniocentesis. A survey of genetics centers.

Although prenatal genetic amniocentesis is an accepted procedure for certain high-risk pregnancies, there is no standard approach to prenatal counseling, timing of counseling, materials used and location of the procedure. This survey of 126 genetics centers offering prenatal genetic amniocentesis reviewed aspects of 48,502 counseling events and a total of 61,174 samples processed in 1982. Eighty-three percent of the samples were obtained after counseling at the centers. Of the patients counseled, 88.5% chose amniocentesis, but the utilization rates varied widely between the centers. The choice of amniocentesis varied measurably with the educational materials used but not with the center size. Educational materials, written or audiovisual, were used by genetics centers in counseling 82% of the patients. There was a wide variation in center size, counseling methods used, the timing and use of counseling, and patient responses in the survey population.

Amniocentesis↗