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Biomedical subjects

D Whitman

Publications and source records attributed to D Whitman.

15 recordsLinked to original sources
PubMed2000

Relationship between dysplasia, p53 protein accumulation, DNA ploidy, and Glut1 overexpression in Barrett metaplasia.

BACKGROUND: There is a need for molecular markers of malignant progression in Barrett metaplasia (BM). The aim of this study is to determine the relationship between dysplasia, p53 protein accumulation, DNA ploidy, and Glut1 in BM. METHODS: Sections of esophageal biopsy specimens from 120 patients with BM were evaluated for dysplasia, p53 protein, and Glut1 expression by immunohistochemistry, and DNA ploidy by Feulgen stain and image analysis. In cases with diploid DNA histograms, the percentage cells in the G0G1 and G2M phases of the cell cycle were determined. RESULTS: Of 108 diploid cases 19 (28%) of 69 cases with G0G1 > or = 90% or G2M > or = 8.33% were p53-positive, in contrast to only 1 (3%) of 39 cases with lower G0G1 or G2M (P = 0.0008). Of 32 p53-positive cases 11 (32%) were aneuploid, in contrast to none (0%) of 88 p53-negative cases (P < 0.0001). Ten (91%) of 11 aneuploid cases were high-grade dysplasial adenocarcinoma (HGD/CA), compared with only 1 (1%) of 109 diploid cases (P < 0.0001). Five (45%) of 11 cases with HGD/CA were Glut1-positive, in contrast to none (0%) of 109 cases without HGD/CA (P < 0.0001). CONCLUSIONS: Our data strongly suggest that in BM, after oxidative DNA damage, as a result of gastroesophageal reflux, there is an increase in the percentage of cells in the G0G1 or G2M phases of the cell cycle to enable repair of damaged DNA; in some of these cases this is followed sequentially by p53 gene mutation and protein accumulation, DNA aneuploidy, HGD, and CA with or without Glut1 overexpression. These events can be detected in routinely processed biopsy samples.

Adenocarcinoma↗
PubMed1999

Comparison of three instruments in predicting accidental falls in selected inpatients in a general teaching hospital.

Accidental patient falls are becoming a major cause of concern for hospitalized inpatients. It is well known that patients who fall once during their hospital stay are more likely to fall again and that fall rates tend to be higher in hospitalized elderly individuals. Concerned health care team personnel recognize that many accidental patient falls may be predicted and, thus, prevented. The best tool to predict falls has not been determined yet. The purpose of this study was to compare the abilities of the Morse Fall Scale (MFS), the Functional Reach (FR) test, and the nurses' clinical judgment in predicting those inpatients on a rehabilitation unit and a geriatric medical ward who were most likely to fall. A total of 98 patients were screened in a 3-month period, with each patient undergoing all three instruments the same day. The results showed that the two objective standardized tests (i.e., MFS, FR) were time consuming and often inconvenient and were no better at prediction than the clinical judgments made by the primary nurses.

Accidental Falls↗
PubMed1998

Activity and passive-avoidance learning in cobalt-injected rats.

A wide range of cognitive-behavioral sequelae, including memory deficits, results from hard metal disease in humans. Cobalt is a common component in the manufacture of hard metals and is a biologically active, toxic substance. This study examined the effects of cobalt exposure in rats. Results showed decreased exploratory behavior and a trend for higher-dose subjects to show decreased passive avoidance learning. No significant differences in active maze learning were found. These results indicate the value of further explorations of the cognitive-behavioral effects of cobalt exposure and suggest a number of methodological cautions.

Animals↗
PubMed1993

MMPI-2 schizophrenia spectrum profiles among schizotypal college students and college students who seek psychological treatment.

The MMPI-2 schizophrenia spectrum profiles of 25 college students with extreme scores on the Perceptual Aberration and Magical Ideation Scales were compared to those of 27 students who requested psychological treatment at a university psychology clinic. Moldin, Gottesman, and Erlenmeyer-Kimling's 1987 classification strategy for schizophrenia spectrum disorders identified 66% of the students who did not seek psychological treatment and had high scores on the Perceptual Aberration and Magical Ideation Scales as having an 8-6, 8-9, or a 9-8 MMPI-2 profile. Of the students who requested psychological treatment, 25% produced MMPI-2 schizophrenia spectrum profiles. Of these, 63% produced a 2-7-8 code profile. Additional analyses showed that only some of the students who requested psychological treatment and produced a 2-7-8 MMPI-2 profile exhibited schizotypal features and that this group stayed in therapy longer than students without schizophrenia spectrum profiles. These results suggest that only a subset of the students with high scores on the Perceptual Aberration and Magical Ideation Scales produce schizophrenia spectrum MMPI-2 profiles and that these profiles are substantially different from those produced by students with high scores on the Revised Social Anhedonia Scale and from schizotypal college students who seek psychological treatment.

Adult↗
PubMed1985

Transplanting life.

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Health Services Accessibility↗