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Biomedical subjects

D White

Publications and source records attributed to D White.

At least 235 records · Page 13Linked to original sources
PubMed1989

Low sexual desire in women: the role of reproductive hormones.

The role of reproductive hormones in mediating sexual desire in healthy women is still unclear. Elucidation was sought in this study by comparing the hormonal milieu of two groups of subjects with markedly different levels of sexual desire. Seventeen women ages 27-39 who met DSM III-R criteria for severe, persistent, and generalized loss of desire (hypoactive sexual desire disorder, HSD), but had no other current psychological or medical problem, were compared to 13 healthy, sexually active women. All subjects and spouses were interviewed extensively to determine the women's sexual desire and responsiveness. Blood samples were drawn every 3 to 4 days for one menstrual cycle and were analyzed by RIA for testosterone, SHBG, estradiol, progesterone, prolactin, and luteinizing hormone. Results indicated that the HSD women's gonadal hormones fluctuated normally over the menstrual cycle, were within normal limits for each cycle phase, and were never significantly different from those of controls. Neither testosterone, non-SHBG bound testosterone, nor prolactin differentiated between the HSD women with the most and least severe HSD parameters (e.g., frequency of fantasy, masturbation, or female-initiated coitus), nor between women with lifelong and acquired HSD. The present findings did not provide evidence that reproductive hormones are important determinants of individual differences in the sexual desire of these eugonadal women.

Adult↗
PubMed1989

Post-registration nursing courses--one way forward.

This paper sets out an alternative method for post-registration nursing courses to the traditional type of 6 or 12 month programmes. The factors involved in precipitating the changes are outlined and the rationale for, and process of, change discussed. The authors believe that shorter, skills based modular programmes--especially at competency (3rd year registered nurse) level--are the key to the future provision of adequate numbers of appropriately skilled registered nurses in the ever increasing number of specialty areas and that these courses must be based upon a strong correlation of theory to advanced clinical practice skills. The paper illustrates this point by describing briefly two of the modular programmes offered at The Queen Elizabeth Hospital, Adelaide.

Australia↗
PubMed1989

Nosocomial bloodstream infection at a veterans hospital; 1979 to 1987.

Studies of nosocomial bloodstream infection (NBI) have come primarily from university, municipal or community hospitals with little specific information from veterans hospitals. The objective of this study was to define trends in NBI at a tertiary care veterans hospital. Patients with NBI were identified by retrospective review of microbiology records and of infection control surveillance records from 1979 to 1987 at the Buffalo Veterans Administration Medical Center (VAMC). Between 1979 and 1985 there was no significant upward or downward trend. Beginning in early 1986 a significant increase in NBI was noted. This increase was because of changes in incidence of gram-positive NBI (primarily Staphylococcus aureus [corrected] and enterococcus) while there was no change in incidence of gram-negative NBI. The most common source of NBI were similar to previous studies and included urinary tract infection, pneumonia, surgical wound infections and intravenous catheter related infections. The frequency of various organisms causing NBI was likewise similar to other studies except for pneumonia in which Streptococcus pneumoniae most commonly was isolated. The yearly incidence of gentamicin resistance among gram-negative NBI isolates demonstrated no significant trend. In conclusion, there was a significant increase in incidence of NBI at the Buffalo VAMC between 1979 and 1987 that occurred primarily in the last two years studied. The importance of gram-positive organisms as a cause of NBI at the Buffalo VAMC has been clearly documented as a recent phenomenon.

Catheters, Indwelling↗
PubMed1989

Detection of rearrangement within the breakpoint cluster region of chromosome 22 in the diagnosis of chronic myeloid leukemia.

Chronic myeloid leukemia (CML) is characterised by the presence of a Philadelphia (Ph) chromosome in approximately 95% of patients. Molecular analysis has shown that the Ph chromosome translocation breakpoints are clustered within 5.8 kb on chromosome 22 (breakpoint cluster region or bcr). This has facilitated the diagnosis of CML by nucleic acid hybridisation using probes specific for the bcr to detect DNA rearrangement in this region. Forty patients diagnosed with CML, including four with variant Ph chromosome translocations and three with normal karyotypes were analysed for rearrangement within the bcr. All except one patient with Ph negative CML had rearrangement within the bcr. In contrast, none of the patients diagnosed with other hematological disorders such as the myelodysplastic or myeloproliferative syndromes (16 patients), acute myeloid leukemia (AML) (six patients), acute lymphoblastic leukemia (ALL) (five patients), including Ph positive ALL (two patients), showed rearrangement within the bcr. Analysis for rearrangement within the bcr is useful in the diagnosis of CML, especially when cytogenetic analysis is unsuccessful or in patients with normal karyotypes or variant Ph chromosome translocations.

Adult↗
PubMed1989

Calcium requirement for gliding motility in myxobacteria.

The ability to glide on a solid surface was inducible by calcium ion in Stigmatella aurantiaca. The induction of motility but not motility itself was prevented by chloramphenicol and erythromycin. Calcium ion was also required for cells to glide, even when they were previously induced. The ability of Myxococcus xanthus to glide in groups using the S motility system but not as single cells (A system) was prevented by chloramphenicol and erythromycin.

Calcium↗
PubMed1989

[Alternative resources and intermediate structures in the context of Québec.].

In Québec, a consensus appears to have developed over the last few years around the need to develop community-based resources in mental health. However, the concept of community resources is fragmented: there is a conceptual distinction between Alternative and Intermediary Resources, both of which are located outside the walls of the institution, but which have different objectives, and suggest different means for supporting the mentally disturbed in the community. Attempts to operationalize these concepts have tended to have the effect of masking their conceptual particularity. In this article, the conceptual distinctions - as they have developed in the Québec context - are clarified, and the implications of erasing them are discussed.

English Abstract↗
PubMed1989

Characterization of CGS 8515 as a selective 5-lipoxygenase (5-LO) inhibitor.

1. CGS 8515 selectively inhibited 5-LO (IC50 = 0.1 microM) with negligible effect on CO, 12-LO, 15-LO and TxS at concentrations up to 100 microM. 2. CGS 8515 selectively inhibited A23187-induced formation of 5-LO products in rat and human whole blood with a 20-70 fold separation of effects over the formation of CO products. 3. Ex vivo and in vivo studies with rats showed that CGS 8515, at an oral dose of 2-50 mg/kg, significantly inhibited A23187-induced formation of LTs in whole blood and in the lung. The effect persisted for at least 6 h in the ex vivo blood model. 4. CGS 8515, at oral doses as low as 5 mg/kg, significantly suppressed exudate volume and leukocyte migration in the carrageenan-induced pleurisy and sponge models in the rat.

Animals↗
PubMed1988

Sex chromosome anomalies, hormones, and sexuality.

Behavioral investigation of men with sex chromosome anomalies has been primarily limited to the study of institutionalized individuals or patient groups. A double-blind controlled investigation of XYY and XXY men found in a birth cohort of 4591 tall men born in Copenhagen gathered sexual information and assessed the role of hormonal determinants on sexual behavior. There were significant differences in several sexual dimensions and in gender role between XYY men and their controls and XXY men and their controls as well as between XYY and XXY men. Although both proband groups differed from each other and from their controls in pituitary gonadal function, there was no evidence that adult hormonal levels mediate the effect of sex chromosome anomalies on male sexuality.

Adult↗