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Biomedical subjects

D Wessinghage

Publications and source records attributed to D Wessinghage.

At least 19 recordsLinked to original sources
PubMed1991

Deposition of amyloid of unknown origin in articular cartilage.

Articular cartilage, obtained from the large toe during hallux valgus operations in 37 patients, was investigated for the presence of amyloid by using the Congo red staining method. Amyloid deposits were demonstrated, particularly in the superficial layer of the cartilage, in 30 cases. This amyloid did not react immunohistochemically with any of the antibodies against the known five major amyloid types (AA, A lambda, A kappa, AF, AB). From these data it is concluded that hyaline cartilage in older individuals is prone to infiltration by an amyloid of a hitherto unidentified class. From the morphological observations there seems to be no correlation between amyloid deposits and the development of osteoarthrosis.

Aging↗
PubMed1990

[Intramedullary nailing of peri-prosthetic fractures following total knee joint replacement].

Based on positive experiences in similar operations of the said method, we report 3 cases of periprosthetic fractures after total knee arthroplasty treated by the principle of intramedullary osteosynthesis. After preoperative X-ray-planning a shorted AO-medullar nail was positioned on the proximal site of the prostheses in combination with autogenous resp. homogeneous bone grafts located in the fracture area. In relation to other procedures the advantages of these compound osteosyntheses are undisturbed periosteal blood supply, correct alignment and consolidation of the fracture, early weight bearing and reliable cement fixation. They legitimate in our opinion the increased effort of partial revision arthroplasty.

Aged↗
PubMed1988

[Basic therapy of chronic inflammatory joint diseases with D-penicillamine and disorders of wound healing in rheumatoid orthopedic interventions].

In the past, D-penicillamine has been thought to cause wound healing disturbances due to its influence on connective tissue. A series of 217 operations in 150 patients with rheumatoid arthritis on D-penicillamine treatment were performed and compared with controls (106 operations in 86 patients with rheumatoid arthritis). It was shown that disturbances of wound healing were less in patients on D-penicillamine therapy (12.4%) than in patients who did not receive D-penicillamine (18.9%). A perioperative withdrawal of D-penicillamine therefore does not seem justified.

Arthritis, Rheumatoid↗
PubMed1987

[Surgical interventions in psoriatic arthritis].

As a general disease, psoriatic arthritis (which besides the skin and the joint can also affect internal organs) takes a special place amongst chronic polyarthritis conditions. It is characterized by combination of psoriasis with a seronegative polyarthritis affecting the spine and above all the joints in the hands and feet (frequently asymmetrically). The form and extent of the often painful joint and spinal involvement not uncommonly lead to an appreciable impairment of various functions and thus to a handicap for the patient. A series of different operations extending from synovectomy to arthrodesis and joint replacement improve the pain as well as functional restrictions. However, they also lead to new knowledge on the nature, etiology and development of this disease via photographic documentation of findings and investigation of the tissue obtained intraoperatively. In the years 1967 to 1984, 457 single operations were carried out in 80 patients with psoriatic arthritis. The results allow the conclusion that patients with psoriatic arthritis should be admitted to special hospitals for surgical treatment more frequently than was the practice up to now.

Adolescent↗
PubMed1987

[Arthrodesis of the wrist joint in patients with polyarthritis].

In rheumatoid arthritis, extreme damage to the wrist joint with rupture of the wrist extensor tendons can only be treated effectively by arthrodesis. The authors describe the technique of wrist fusion by an AO-plate. Twenty-two arthrodeses have been performed between July 1974 and June 1984, representing 7.4% of all surgical procedures on rheumatoid wrists (n = 294). Radial deviation and dorsiflexion of the hand must be avoided. Follow-up was possible in nine patients (eleven wrist-fusions). All these patients were satisfied with the result.

Adult↗
PubMed1986

Proliferation of pannus tissue cells in rheumatoid arthritis.

Proliferation of pannus tissue cells has been investigated under in vitro conditions after labeling of joint tissues with 3H-thymidine. It was demonstrated that there is only a minimal proliferation of chondrocytes as well as of pannus tissue cells. Slight increased proliferation was observed in granulation tissue poor in lymphocytes and plasma cells, and perhaps in those areas of destroying pannus tissue that exhibited polymorphonuclear granulocytes (PMNs) at the pannus-cartilage junction. These results are in contrast to the idea that pannus tissue is a tumor-like lesion, for the present observations, even within the limits of autoradiographic investigations on a heterogeneous tissue, and indicate that pannus tissue has to be regarded as an inflammatory granulation tissue.

Arthritis, Rheumatoid↗
PubMed1986

[Subcutaneous leiomyosarcoma of the hand].

Leiomyosarcoma of the hand is a rare tumor. A case report of a leiomyosarcoma lying in the superficial tissues of the dorsal aspect of the right hand in a 64-year-old woman is given. Nine months after initial excision a local recurrence appeared and was treated by radical local excision and free skin grafting. The follow-up is now seven years. The patient is free of tumor and metastases. A review of the literature is given. The problems in therapy of leiomyosarcoma of skin and superficial tissues are discussed.

Female↗
PubMed1985

S-100 protein in normal, osteoarthrotic, and arthritic cartilage.

The occurrence of the S-100 protein was studied in normal and pathological cartilage from patients with osteoarthrosis and rheumatoid arthritis. In normal cartilage all cells of the different zones exhibit immunoreactivity for this protein. An identical distribution is observed in cases of osteoarthrosis and rheumatoid arthritis. Cellular pannus tissue usually is devoid of the S-100 protein. However, if chondroid metaplasia occurs in this tissue the cells become positive for the S-100 protein. From these results it is concluded that a chondroid metaplasia not only leads to a matrix comparable to cartilage but also contains cells that gain further characteristics of original chondrocytes.

Adult↗
PubMed1985

[Intraoperative electroneurography during decompression of the median nerve in the carpal tunnel].

Observations in 261 patients suffering from carpal tunnel syndrome in whom 303 decompressions of the median nerve had been performed led us to the conclusion that a definite improvement of the transmission rate occurs during operation. Distal latency has been measured during operation in 20 patients before and after transecting the flexor retinaculum, after neurolysis and also after releasing the tourniquet. Our findings confirm a positive effect on the transmission rate occurring immediately after transecting the flexor retinaculum.

Carpal Tunnel Syndrome↗
PubMed1985

[Tenosynovitis in chronic inflammatory joint diseases and its sequelae in the area of the hand].

The synovial lining of tendons may participate early in chronic rheumatic diseases. As a result of the inflammatory activity degenerative changes of tendons may occur. Increasing damage to tendons ends in their rupture. At 775 tenosynovectomies, 395 of them in chronic rheumatic diseases, in 68 patients (78 hands) 173 ruptures of tendons (14 flexors, 159 extensors) were found. The value of early tenosynovectomy as a preventive measure is emphasized.

Arthritis, Rheumatoid↗
PubMed1979

[Synovectomy].

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Arthritis, Rheumatoid↗