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Biomedical subjects

D Welsh

Publications and source records attributed to D Welsh.

28 records · Page 2Linked to original sources
PubMed1986

Palliative topical and systemic misonidazole with low-dose irradiation for recurrent carcinoma of the cervix uteri.

This report concerns a determinate series of 11 patients with progressive recurrent cancer of the cervix uteri, who were treated with misonidazole (1 g) applied locally for 24 hours and an oral dose of 2.9 g/m2 four hours before a single mid-plane dose of 5.00 Gy. Four of 11 (36%) remained free of disease at one year. It is suggested that this is largely a hypoxic cell cytotoxic effect and is a useful method of palliation.

Carcinoma, Squamous Cell↗
PubMed1984

Reaction times to weak test lights.

Maloney and Wandell [Vision Res. 24, 633-640 (1984)] describe a model of the response of a single visual channel to weak test lights. The initial channel response is a linearly filtered version of the stimulus. The filter output is randomly sampled over time. Each time a sample occurs there is some probability--increasing with the magnitude of the sampled response--that a discrete detection event is generated. Maloney and Wandell derive the statistics of the detection events. In this paper we test the hypothesis that the reaction time responses to the presence of a weak test light are initiated at the first detection event. This permits us to extend the application of the model to lights that are slightly above threshold, but still within the linear operating range of the visual system. We test a parameter-free prediction of the model proposed by maloney and Wandell for lights detected by this statistic. The data are in agreement with the prediction.

Humans↗
PubMed1982

Adaptation in the long-wavelength pathways.

We describe and test predictions of a model of long-wavelength test sensitivity upon large, uniform backgrounds. The model explains changes in sensitivity in the red-green detection pathways strictly based upon losses of sensitivity in the receptors. We derive the prediction that field mixture data for field-mixtures of mu1 (fixed) and an addend, mu 2, must follow the same shape on different intensities of the fixed background, mu 1. This prediction is not in good agreement with the measurements.

Adaptation, Ocular↗
PubMed1980

Stage I cervical carcinoma: local experience in Port Elizabeth with 5-year follow-up.

Seventeen patients who presented with stage i squamous carcinoma of the cervix between 1969 and 1974 are reviewed. Thirteen of the patients were treated by means of radical irradiation, 3 by Wertheim's hysterectomy and 1 by a simple hysterectomy and postoperative pelvic irradiation. Two patients died 2 years after presentation, 1 from metastases and 1 from unrelated causes. The remaining 15 patients were well with no evidence of malignancy 5 years after presentation.

Adult↗
PubMed1980

Transcription of killer virion double-stranded RNA in vitro.

Intracellular virions of stationary phase ethanol-grown cells of a killer strain of Saccharomyces cerevisiae contain encapsulated M (1.1 x 10(6) dalton) and L (3.2 x 10(6) dalton) double-stranded RNA plasmids. These virions also contain RNA polymerase activity which catalyzes the synthesis of full-length, single-stranded, asymmetric transcripts (denoted m and l) of the virion double-stranded RNAs. Product m is made by M-containing particles and shows complete sequence homology to M but not to L. Product l is made by L-containing particles and shows complete homology only to L. The products show no self-homology, indicating asymmetric transcription. Therefore, the polymerase appears to function in vitro as a double-stranded RNA transcriptase. The lack of sequence homology between M and L is confirmed.

Base Sequence↗
PubMed1980

The diagnosis and treatment of intramuscular hemangiomas of the masseter muscle.

Two cases of hemangioma of the masseter muscle are presented with a review of the literature. The possibility of an intramuscular hemangioma should be considered in any lateral facial swelling, particularly one anterior to the parotid. Total excision of the hemangioma with a margin of normal muscle is recommended. The approach utilized by the authors is a preauricular incision with elevation of a flap lateral to the parotid gland. This provides an excellent exposure for removal of the tumor with minimal risk to the facial nerve and minimal cosmetic deformity.

Blood Vessels↗
PubMedDate not supplied

Interdisciplinary development of an intravenous infusion protocol for Orthoclone OKT3.

The development and implementation of an infusion protocol for Orthoclone OKT3 (Ortho Biotech, Inc., Raritan, NJ) is described in this article. OKT3 is a potent immunosuppressant drug used to lower the incidence of graft rejection in transplant patients. Nurses and physicians use the protocol described in this article to administer OKT3 to heart and lung transplant patients at our institution. Pharmacokinetics, along with the nursing care, associated with OKT3 administration are described in the protocol section. The benefits of protocol use are reported in the conclusion.

Humans↗