Perforated jejunal ulcer and heterotopic gastric mucosa.
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Biomedical subjects
Publications and source records attributed to D Weedon.
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A case of ischaemic ileal necrosis is reported. It was associated with elastic vascular sclerosis produced by mesenteric metastases of an ileal carcinoid tumour.
A case of terminal ileitis, mesenteric lymphadenitis and appendicitis is reported. Serological studies indicated infection with Yersinia pseudotuberculosis type VA. The patient's illness ran a chronic course necessitating resection of the terminal ileum. Histological examination of the appendix and a mesenteric lymph node in the acute stage revealed granulomas with central necrosis. This is the first human case in which the subtype VA has been identified.
A case of basal cell carcinoma which metastasized to an axillary lymph node is presented. There were no histological features that enabled either the presumed primary lesion or the metastasis to be distinguished from the usual non-metastasizing basal cell carcinoma. Evidence is presented that metastasis is considerably less freguent in Queensland that is reported in an overseas series.
The ultrastructure of two atypical fibroxanthomas of skin is described. Most of the tumour cells were elongate, and contained abundant rough endoplasmic reticulum, well developed Golgi zones, and numerous small vesicles and filaments, the latter sometimes being related to masses of electron-dense material near the plasma-lemma. Their nuclei often showed deep surface indentations. The appearances were similar to those found in the socalled myfibroblasts that occur in granulation tissue. Multinucleated giant cells and lipid-laden cells in the tumours appeared to be merely modified forms of the basic cells type.
A keratoacanthoma centrifugum marginatum measured 20 X 14 cm at the time of surgical intervention. This lesion is characterized by continuing peripheral extention and central healing. Attention is drawn to the occurrence in the healing edge of a distinctive type of individual cell necrosis, which has been described by others in the more usual forms of keratoacanthoma. The findings are of interest, since this same mode of cellular death has recently been shown to be involved in the regression of various tissues, normal as well as abnormal.
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