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Biomedical subjects

D Weedon

Publications and source records attributed to D Weedon.

At least 55 records · Page 3Linked to original sources
PubMed1983

Actinomycosis of the gall bladder.

This report describes the sixth case of actinomycosis of the gall bladder and discusses the salient features of the diagnosis and management of this rare disease.

Actinomycosis↗
PubMed1983

The diagnosis of Hutchinson's melanotic freckle (lentigo maligna) in Queensland.

Following an increase in the reported incidence of melanoma of Hutchinson's melanotic freckle type (HMFM) in Queensland, a review of its histological diagnosis was undertaken. Ninety-nine pigmented lesions reported by 13 different pathology laboratories throughout Queensland as having an in-situ component of Hutchinson's melanotic freckle (HMF) were reviewed by 2 pathologists with an interest in malignant melanoma. This diagnosis was confirmed in 76 cases while in a further 3 the reviewers regarded the in-situ component as indeterminate. It would seem that the level of agreement among pathologists reporting HMF(M) should be considered in any assessment of incidence patterns of melanoma.

Diagnosis, Differential↗
PubMed1982

Unusual cutaneous reactions to injections of corticosteroids.

The injection of corticosteroids into the skin results in the appearance of granular material in the dermis which usually disappears within 2 weeks of the injection. In one of two unusual reactions recently seen by us, there was a granulomatous foreign-body response to injected corticosteroid, whereas in the second there was a granulomatous reaction that resembled rheumatoid nodule.

Adrenal Cortex Hormones↗
PubMed1982

A reappraisal of melanoma in situ.

Sixty-six cases of melanoma in situ were randomly selected from the files at the Royal Brisbane Hospital, Australia, and multiple deeper sections were cut from the paraffin blocks. An invasive component (Level II) was found in eight cases, with a thickness ranging from 0.19 to 0.45 mm. No recurrences or metastases have developed after at least five years. Focal areas of regression were present in the initial sections in all but one of these eight cases.

Humans↗
PubMed1981

The urethral syndrome: morphological studies.

Tissue removed at Richardson urethroplasty from 50 patients with the urethral syndrome, together with material obtained from the urethras of 44 cadavers, was examined in an attempt to elucidate the pathological basis for this syndrome. There was a significant increase in fibrous tissue in the urethrovaginal septum, accompanied by a loss of smooth muscle fibres and focal clumping of elastic tissue, in patients with the urethral syndrome.

Collagen↗
PubMed1981

Elastotic nodules of the ear.

Eight cases of an elastotic degenerative lesion, developing on the ears in response to actinic damage are reported. Elastotic nodules may be diagnosed clinically as basal cell carcinoma, amyloid or even gout. Although usually found on the antihelix of the ear, they may arise on the helix and simulate chondrodermatitis nodularis helicis.

Aged↗
PubMed1981

Apoptosis as the mechanism of the involution of hair follicles in catagen transformation.

Electron microscopy was performed on mouse skin to study the mechanism of the spontaneous involution of hair follicles during catagen. The reduction in follicles size appears to result from cell deletion by apoptosis, a distinct type of cell death with importance in tissue kinetics. These ultrastructural changes have been misinterpreted in the past as autophagic vacuole formation because of the prominent phagocytosis of the apoptotic fragments by adjacent, surviving cells of the hair follicle.

Animals↗
PubMed1980

Matrical carcinoma of the skin.

Two elderly patients with unusual hair-follicle tumors of the face are reported. The lesions showed some histologic resemblance to pilomatrixomas but differed by the presence at the advancing edge of cytologically-atypical cells without the usual shadow cell transformation and maturation of pilomatrixomas. The term matrical carcinoma is proposed for these tumors.

Aged↗
PubMed1980

Melanosis of the gall bladder.

A case of melanosis of the gall bladder is described. Ultrastructural examination confirms that the pigment is related to lipofuscin.

Aged↗