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Biomedical subjects

D Wassermann

Publications and source records attributed to D Wassermann.

85 records · Page 5Linked to original sources
PubMedDate not supplied

[Limb vasodilation provoked by stimulation of the carotid sinus. Importance of histaminergy in the dog].

The vasodilator reflex induced by baroreceptor stimulation was studied on the hindlimbs of the dog. The reflex was induced by norepinephrine (1 microgram/kg) either by intravenous injection or by direct injection into the carotid sinus. In other experiences, the baroreceptor stimulation was obtained by distension of the sinus by rapid injection of 100 ml of physiological serum. The vascular response was studied by recording the hindlimbs blood flow. One of the limbs was previously pretreated by mepyramine and cimetidine (blockage of histaminergic H1 and H2 receptors). During the first minute after the baroreceptor stimulation, blood samples were collected from the venous blood of hindlimbs for histamine assay (fluorometric assay). Our results show: a much lower vasodilation on the limb pretreated by histamine antagonist, a significant increase during the reflex vasodilation of histamine blood levels measured in the efferent blood of hindlimbs. These results, obtained in experimental conditions as physiological as possible (blood perfusion of the limbs with "natural" hemodynamic parameters) permit to conclude that the vasodilation induced by baroreceptor reflex is at least partially histaminergic in the dog.

Animals↗
PubMedDate not supplied

[New light on the discussion about the therapeutic attitude during the first 72 hours in subjects highly burned. Study of 100 patients burned on 30 p. cent of body surface or more (author's transl)].

The quantity of given fluids was guided by the Evans rule but with no limitations of infusion above 50 p. cent of burns. Fluid was concentrated human serum albumine made isotonic by infusion through a Y pathway with 5 p. cent glucose, natrium (6 g/l) and carbo-hydrate for caloric needs. Under these conditions, clinical and biological parameters show the keeping of a good hemodynamic and hydroelectrolytic balance, with a level of blood proteins very near of the normal one, and a raise in body weight much lower than usually described in literature. Beyond this, the time needed to lower the body weight to its initial level is short and the quantity of infused liquid is much lower than that requisited by resuscitation utilising only cristalloid fluids for the first 24 hours.

Acid-Base Equilibrium↗
PubMedDate not supplied

[Evolution of blood fatty acid levels in severe burns].

During the first ten days following the burn, there is no significant increase in serum FFA for the surviving patients. This shows a good balance between production and use by the cells. The glucose that is brought allows their oxydation in tricarboxylic Kreb's cycle and the albumine allows for them transport in the circulating liquids, probably helping to maintain this good balance. On the other hand for 70 p. 100 of the patients who died this equilibrium does not exist and the serum FFA increased significantly. Later on and in all cases, the value of serum FFA decrease significantly below that of the control group. This fact can be explained by the exhaustion of the lipidic reserves and/or a decrease of serum proteines particularly albumin, and consequently of transport in the blood of the fatty acids.

Adolescent↗