Hyponatremia during carbamazepine treatment.
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Aged↗
Biomedical subjects
D Warot
Publications and source records attributed to D Warot.
Single dose of prednisone does not induce amphetamine-like subjective effects in healthy subjects.
Among the methods developed in assessing abuse liability, the behavioural and subjective effects of drugs can be recorded using the Addiction Research Center Inventory (ARCI) in drug-experienced subjects and normal volunteers. Sixteen healthy volunteers with no history of drug abuse participated in the study. The subjective, behavioural and physiological effects of prednisone (30 and 60 mg) were compared with those of dextroamphetamine (15 mg) and placebo in a randomized double-blind Latin square design. The self-questionnaires (ARCI, Profile of Mood States, Visual Analogue Scales and Sleep Questionnaire) were completed before, 1, 2, 4 and 8 h post single oral dosing. Results showed that subjective effects of the two studied doses of prednisone did not resemble those induced by dextroamphetamine (15 mg). These results indicate that oral single doses of prednisone do not possess amphetamine-like subjective effects in a healthy population. The well established psychostimulant effect of amphetamine have been replicated on almost all subjective assessments.
Adult↗
Cognitive impairments induced by triazolam in healthy volunteers: antagonism by a partial inverse agonist of benzodiazepine receptor.
Pharmacological studies revealed that SR 25776 possesses marked stimulant activity characteristic of a partial inverse agonist of benzodiazepine receptor. The effects of SR 25776 500 mg alone and in combination with triazolam 0.25 mg on psychomotor performance and memory were assessed in 8 healthy consenting male volunteers in a double-blind placebo controlled trial. Treatment effects were monitored before and two and half hours following oral medication. The present study suggest that at the studied dose SR 25776 may incompletely antagonize the sedative and amnesic effects of a benzodiazepine agonist without producing marked effects of its own.
Adult↗
[Value of autoquestionnaires in the evaluation of sex disorders related to drugs].
Symptoms can be assessed by the subject or the patient himself. Drug-related sexual dysfunction may be of clinical relevance for medication compliance. Three kinds of self-rating scales are available: yes/no questionnaire, multiple choice questionnaire and visual analogue scales. Self-rating can be absolute (intensity score) or relative (improving or worsening score), over last rating or over baseline. Self-rating necessarily implies: comprehension of the vocabulary and the instructions by the subject; cooperation of the subject; and careful checking of the answers by the clinician. Main metrologic qualities are sensitivity, reliability and validity. To assess changes in sexual function, the "golden" sexual function questionnaire does not seem to exist. Separate questionnaires are provided for men and women with appropriate changes for specific items. The number of questions varies from 4 to 20 even more. Several aspects of the male and female sexuality must be studied. Two main questions can be raised: 1) is there any relation between responses obtained with self-reported questionnaire and responses to questioning by a clinician? is there any relation between self-reported sexual dysfunction and objective measures of sexual function like plethysmography?
Female↗
[Addictive potential in man: methodological aspects].
Different methods have been developed in clinical abuse liability testing in man. Tolerance, psychic and/or physical dependence must be investigated through clinical studies during drug development of a new substance. Adequate methodology is needed using double-blind, time-blind evaluations, comparisons of different dose levels and duration of treatment for a given drug, abrupt and gradual interruption of treatment, appropriate period of observation after treatment cessation ... The optimal scale to evaluate properly the symptoms occurring after drug discontinuation is still under investigation. These studies will or should permit the differentiation of rebound, withdrawal and recurrence. Methods developed to study reinforcing effects in post-addicts and healthy subjects are self-administration and choice procedures. In addition, the more traditional approach has been through assessing self-reported effects in which standardized questionnaires are used (Addiction Research Center Inventory or A.R.C.I.; Single Dose Questionnaire or S.D.Q.). A third focus of measurement has been discrimination studies performed in individuals with histories of drug abuse as well as healthy subjects. Abuse-liability testing of a new compound needs a multidimensional assessment to optimize the predictivity in defining the relative risk.
Behavior, Addictive↗