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Biomedical subjects

D Walker

Publications and source records attributed to D Walker.

At least 397 records · Page 22Linked to original sources
PubMed1975

A predictive test for the selection of cancer chemotherapeutic agents for the treatment of human cancer.

The use of animals for the screening of chemotherapeutic agents effective against cancer is not always satisfactory. In addition to the problems of cost, space, and care, the results obtained by animal screening do not always parallel those obtained by the clinical use of the agents. With the advent of more refined in vitro technics which can be applied directly to the patient's own tumor tissue, additional information may permit a more critical evaluation of the laboratory findings. The critical index of sensitivity probably lies in the combined evaluation of biochemical analysis and observed morphological damage. From this investigation it would appear that tissue culture of human tumors may serve as a valuable adjunctive method for the screening of chemicals in order to find drugs valuable in the treatment of cancer in man and to serve as a method in the selection of the most effective therapeutic agent for a given tumor in a given patient.

Antineoplastic Agents↗
PubMed1975

Psychological factors in hypospadias repair.

Children undergoing hypospadias repair and their parents have anxieties related not only to the operation but to future expectations. These anxieties are expressed by children through their drawings and by parents through interviews. They are enhanced by the fact that the hypospadias defect is only noticeable to the parents and child and is kept as secret information. Other defects, such as cleft palate, are obvious and cannot be hidden. The anxieties associated with hypospadias appear to be different whem compared to those associated with more obvious deformities.

Adult↗
PubMed1975

Elastic characteristics of the ureter.

An explanation was sought as to why the ureter becomes tortuous with increased intraluminal pressure. Changes in ureteral diameter and length, secondary to increased intraluminal pressure, were measured in different pathologic conditions and these changes were compared to similar ones in a non-biologic material (latex rubber tubing). It was demonstrated that these changes were anisotropic and remarkably similar under quite different pathologic conditions. Ureteral tortusity occurring secondary to increased intraluminal pressure may be related to anisotropic expansion of a tube with both ends in a fixed position.

Dilatation↗