Serotonin receptors. III. The role of salt formation.
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Biomedical subjects
Publications and source records attributed to D W WOOLLEY.
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Nicotinamide in large amounts antagonized the action of serotonin on smooth muscles in vitro and in vivo. It also tranquilized animals. The antagonism differed in some respects from that of an antimetabolite of serotonin.
The data now at hand show that specificity among biologically active peptides is probably not as exquisite as might have been deduced from experiences with some of the water-soluble vitamins. It is plain that a given biological effect can be evoked by peptides which differ considerably. It is likewise plain that the effect cannot be evoked by a number of other peptides. There is apparently some specificity, but more is involved than that incorporated in the classical view.
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