Mean blood pressure and heart rate have been registered in the experiments on male Wistar rats. Kallikrein-kinin system (KKS) components have been evaluated in blood plasma: plasma kallikreinogen, kallikrein-inhibiting capacity, spontaneous esterase activity. The parameters were determined before and after hemorrhage in the volume accounting for 10, 20 and 30% of the circulating blood volume. The rats were administered enkephalin analogues--DAGO, DADL and naloxone. The administration of mu-agonist DAGO improved hemodynamics. DAGO effect was eliminated by naloxone. The administration of enkephalins did not affect KKS parameters, while naloxone potentiated KKS changes induced by hemorrhage. It has been shown that KKS is not involved into the mechanism of hemodynamic changes in response to enkephalin administration during hemorrhagic shock.

Animals↗

PubMedDate not supplied

[The negative effect of enkephalins on kidney energetics in rats with hemorrhages].

Content of adenine nucleotides, lactic and pyruvic acids, glucose and fructose-6-phosphate was studied in kidney of rats with hemorrhage constituting 3% of body mass after intravenous administration at a dose of 100 mg/kg of agonists of mu-opiate receptors DAGO and delta-opiate receptors DADL and dalargin. Stimulation of both these types of receptors amplifies the kidney ischemia developed after hemorrhage, which was expressed as increased decomposition of ATP, decrease in energetic charge of the adenine nucleotide system (DAGO) and increase in content of AMP (DADL, dalargin).

Adenine Nucleotides↗