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Biomedical subjects

D W Pryce

Publications and source records attributed to D W Pryce.

12 recordsLinked to original sources
PubMed1995

Flow motion in peripheral diabetic neuropathy.

1. Flow motion is the cyclical variation in blood flow owing to the rhythmical opening and closing of arterioles. Previous studies have suggested that cutaneous flow motion may be altered in diabetic neuropathy but have not been consistent in their findings. 2. In order to assess the effect of diabetic peripheral neuropathy on flow motion, we have examined the frequency and amplitude of flow motion in 12 patients with diabetic peripheral neuropathy, 10 age-matched diabetic patients without peripheral neuropathy and 10 age-matched non-diabetic controls. 3. Peripheral neuropathy was diagnosed by a history of foot ulceration or chronic painful neuropathy, clinical examination and abnormal peroneal nerve conduction velocities. Blood flow, using laser Doppler flowmetry, was measured at four sites on the dorsum of both hands and feet. Flow motion was analysed using fast Fourier transform analysis, between 0.05 and 0.2 Hz, and displayed on a power spectral density graph. Predominant frequency and relative amplitude of flow motion were calculated. 4. Relative amplitude and frequency of flow motion were similar in the hands of all three groups, as was the frequency in the feet of the three groups. Relative amplitude was significantly smaller in the feet of diabetic patients with neuropathy (median 7.2%, 95% confidence interval 4.9-9.4%) than in diabetic patients without neuropathy (median 13.5%, 95% confidence interval 6.3-21.5%, P < 0.02) or in non-diabetic control subjects (median 10.3%, 95% confidence interval 6.9-27.4%, P < 0.02). 5. Flow motion amplitude is reduced in diabetic peripheral neuropathy. The control of flow motion amplitude appears to be at least partly under neurological control.

Diabetes Mellitus↗
PubMed1994

A family with pachyonychia congenita affecting the nails only.

A family with pachyonychia congenita in which affected individuals showed nail involvement only is described. Pachyonychia congenita is a rare hereditary disorder inherited in an autosomal dominant manner. Various classifications of pachyonychia congenita have been suggested but none indicates nail involvement as a solitary finding.

Adult↗
PubMed1993

Hemodynamics of leg ulceration assessed by laser Doppler flowmetry.

BACKGROUND: Cutaneous blood flow and the venoarteriolar reflex can be assessed in the leg by laser Doppler flowmetry. OBJECTIVE: Our purpose was to compare these measurements in ulcerated and nonulcerated skin in venous and arterial disease and to determine whether either changes with healing. METHODS: Studies were performed in 20 patients with venous disease, 16 with arterial disease, and 12 control subjects and repeated sequentially in 15 patients with small venous ulcers until they healed. RESULTS: Blood flow in nonulcerated skin was greatest in venous disease (but not when severe ulceration was excluded). The reflex was exaggerated in nonulcerated skin in venous disease but attenuated in the base of both venous and arterial ulcers. The reflex reappeared in the base of the venous ulcers as they healed. CONCLUSION: Measurement of the venoarteriolar reflex in nonulcerated skin distinguished between venous and arterial disease and its reappearance in the base of venous ulcers was associated with healing.

Aged↗
PubMed1993

Scalp cyst with heterotopic brain tissue.

A multilocular scalp lesion was noticed at birth in a female infant. There was no underlying skull defect. Histological examination revealed neural tissue staining with S-100 and GFAP, but not with a neurofilament stain, which is in keeping with a glial cell origin. Heterotopic brain tissue is a rare developmental abnormality, which usually has no effect on neurological development. It should be considered in the differential diagnosis of scalp lesions in neonates.

Brain↗
PubMed1992

Inflammatory ringworm with unusual features.

Zoophilic dermatophyte infections are often inflammatory but severe widespread inflammatory lesions of glabrous skin, as in the female patient described, are unusual. Most cases of M. canis ringworm can be traced to an infected animal. This dermatophyte is associated with a variety of clinical presentations on glabrous skin and is being isolated with increasing frequency in some countries.

Adult↗
PubMed1991

A histopathological study of 643 cutaneous horns.

A retrospective study of 643 cutaneous horns examined in our department between 1970 and 1989 revealed that 38.9% were derived from malignant or premalignant epidermal lesions, and 61.1% from benign lesions. Four main features were associated with premalignant or malignant histopathological change at the base of a cutaneous horn (base pathology). These were: (i) age--the mean age of the patients whose cutaneous horns showed premalignant or malignant base pathology was 8.9 years greater than the mean age of the patients where base pathology was benign (P less than 0.0005); (ii) sex--males were more likely to develop a cutaneous horn with (pre)malignant base pathology (P less than 0.001); (iii) site--over 70% of all (pre)malignant lesions were found on the nose, pinnae, backs of hands, scalp, forearms and the face; a cutaneous horn found at these sites was 2.1 times more likely to have derived from a (pre)malignant base than from any other part of the body (P less than 0.0001); (iv) geometry of the lesion--lesions with a wide base or a low height-to-base ratio were significantly more likely to show (pre)malignant base pathology. Of those solar keratoses giving rise to cutaneous horns, 8.9% also showed histological evidence of change to squamous cell carcinoma (SCC); this figure was not significantly different from the 6.2% of solar keratoses without horns that showed SCC change during the same period (1970-89).

Age Factors↗
PubMed1990

Orofacial granulomatosis associated with delayed hypersensitivity to cobalt.

Orofacial granulomatosis is a distinct clinical and pathological entity characterized by swelling of the lips and lower half of the face. Ulceration of the oral mucosa may also occur. Granulomas are seen histologically. Orofacial granulomatosis may occur in the Melkersson-Rosenthal syndrome, granulomatous cheilitis of Miescher, oral Crohn's disease, sarcoidosis and focal dental sepsis. The increased prevalence of atopy in patients with orofacial granulomatosis and the association with food intolerance suggests the possibility of a role for allergy in at least some cases.

Child↗
PubMed1989

Soluble oil dermatitis: a review.

Cutting fluid technology has rapidly developed, presenting dermatologists and occupational physicians with a changing pattern of skin disease. The use of soluble oils has increased, and has been followed by an increase in the incidence of eczematous dermatitis. This is usually an endemic, chronic, irritant contact dermatitis, but thorough patch testing can also reveal allergic contact dermatitis. In conditions of heavy exposure, the prevalence of dermatitis can be as high as 30 per cent. Individual susceptibility is very variable. Research into resistance factors in those who do not develop dermatitis, and susceptibility factors in those who do, may elucidate basic mechanisms of irritancy. Efforts must continue to be directed at prevention because, once established, soluble oil dermatitis can be slow to resolve, even after specialist treatment and change of job. Prevention can be directed at the machine operative, the soluble oil, and the machine.

Dermatitis, Contact↗
PubMed1989

Soluble oil dermatitis: a follow-up study.

A pilot follow-up study of patients with soluble oil dermatitis was designed to investigate the effects on prognosis of aetiology and of stopping working with soluble oils. A questionnaire was sent to 121 machine operators who had been diagnosed over a 5-year period. Life table analysis of the 100 replies (83%) revealed a poor prognosis both for those who had continued to work with soluble oils and for those who had stopped. 78% (95% confidence intervals: 63%-94%) of those who continued to work with soluble oils had not healed 2 years after diagnosis. 70% (95% confidence intervals: 56%-83%) of those who stopped working with soluble oil had not healed 2 years after discontinuing contact. Both groups were divided into 4 subgroups with different combinations of aetiological components: allergic and endogenous, non-allergic and endogenous, allergic and non-endogenous, non-allergic and non-endogenous. No significant difference in outcome emerged in either the discontinued contact group or the continued contact group between any aetiological subgroups. Patients who discontinued contact with soluble oils fell into 2 groups: those who healed rapidly and those who developed a chronic dermatitis. 11 of the 15 patients who had healed after 2 years had done so within the first 3 months following cessation of contact. No factor could be identified to distinguish those with the more favourable prognosis. The implications of this study for the management of soluble oil dermatitis are discussed.

Adolescent↗