Biomedical subjects
D W Lamberts
Publications and source records attributed to D W Lamberts.
The corneal endothelium and central corneal thickness in pigmentary dispersion syndrome.
The corneal endothelial cell count and central corneal thickness of 20 eyes of patients with pigmentary dispersion syndrome and 20 age-, sex-, and refractive error-matched control eyes were investigated in a masked fashion with a specular microscope and a pachometer. Despite the existence of glaucoma and different degrees of pigment dispersion with Krukenberg's spindles, there was no significant difference in the central corneal endothelial cell density and central corneal thickness between these two groups.
Systemic tetracycline hydrochloride as adjunctive therapy in the treatment of persistent epithelial defects.
Recent evidence shows tetracyclines have anticollagenolytic activity that may be clinically effective in disease treatment. This led us to use systemic tetracycline (oral tetracycline hydrochloride 1 g daily divided into 4 doses) as adjunctive therapy in treating 18 patients with persistent corneal epithelial defects. Fourteen of 18 patients healed their defects; within 48 hours (9 patients) and within two weeks (the other 5 responding patients). Two patients showed no effect and two showed disease progression.
Recovery of vaccinal poliovirus type 1 from conjunctiva of an infant with transient, unilateral conjunctivitis.
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Schirmer test after topical anesthesia and the tear meniscus height in normal eyes.
The height of the inferior tear meniscus was measured in 86 normal eyes. A value greater than 0.1 mm was obtained in 93% of the eyes that were studied. However, attempts to correlate meniscus height with subsequent Schirmer test results showed that these measurements varied randomly. Schirmer tests that were conducted on 265 eyes without instillation of 0.5% proparacaine hydrochloride and on 466 eyes with proparacaine showed that topical anesthesia reduced mean test values by 40%. When proparacaine was used prior to testing, no decrease in tear production with advancing age was demonstrated, nor were results significantly different in males and females. Schirmer test values, ranging from 0 to 3 mm, were obtained in 15% of the normal volunteers when the test was performed after instillation of topical anesthesia and after blotting of the tear lake from the inferior cul-de-sac.
Vitrectomy for diabetic traction retinal detachment.
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An illuminated grid for macular testing.
The status of the macula should be included in the preoperative evaluation of patients about to undergo keratoplasty or cataract extraction. Frequently, corneal opacities or cataracts preclude visualization of macular details. In such cases, the Amsler grid is useful in assessing macular function. This study evaluated 15 patients with opaque media. In 13 patients, the opacity was too dense to allow the patient to see the Amsler grid. However, all 13 patients could see the illuminated version of the grid. Of the three abnormal responses detected by the use of the illuminated grid, two were caused by macular pathology and one by amblyopia.
A clinical study of slow-releasing artificial tears.
The slow-releasing artificial tear (SR-AT) is a soluble polymer in solid form. Placed in the inferior cul-de-sac and allowed to dissolve, it is used to treat dry-eye patients. The SR-AT was studied in two phases. The short-term cross-over study of 40 patients was completed in October 1976. The long-term open study is still in progress. Of 37 patients who started the long-term study, 18 are still using the inserts-a study retention of 49%.
A new alloplastic material for ophthalmic surgery.
The application of Proplast in ocular surgery is in an early stage. We believe our preliminary work may offer a solution to the problem of erosion and slippage common to other types of implants. We are currently investigating the potential of Proplast in keratoprosthesis. Proplast may prove useful in buckles and implants for retina detachment as well as stabilizing splints for blow-out fractures. Proplast is an inert, carbon and Teflon alloplast, not previously described in the ophthalmic literature. Corneal and scleral implants in rabbits are well tolerated. Proplast is porous and microscopic examination of the implants show fibrovascular ingrowth within its matrix, thereby incorporating it into the host tissue. The rate at which the implant is incorporated by host tissue ingrowth and the long-term acceptance of the alloplast have yet to be determined.
Chronic unilateral external ocular inflammation.
To diagnose the cause of chronic unilateral external ocular inflammation, the physician must take into account many factors usually not considered in bilateral cases. We report on the diagnosis and treatment of ten unilateral cases encompassing a variety of ocular and systemic problems. The purpose of this report is to emphasize the importance of systematic consideration of all diagnostic possibilities and to suggest a diagnostic protocol to aid in the study of patients with chronic unilateral external ocular inflammation.