Search PubMed⌕ Search

Biomedical subjects

D W Jones

Publications and source records attributed to D W Jones.

206 records · Page 12Linked to original sources
PubMedDate not supplied

Differentiation of amphetamine and its major hallucinogenic derivatives using thin-layer chromatography.

Psychotropic, ring-substituted amphetamine derivatives can be differentiated from each other and from over-the-counter drugs using a sequential TLC detection technique. The improved detection is accomplished by distinct differences in color through four detection stages. Reported in the tables are Rf values in two solvent systems, the color characteristics through the four detection stages and in two confirmatory reagents, and the minimum detectible concentrations in urine of 19 amphetamine derivatives.

Amphetamine↗
PubMedDate not supplied

Drug population in one thousand geographically distributed urine specimens.

Hundreds of drugs and other substances are excreted in urine. In a comprehensive drug screen, it is impossible to identify every detectable substance. In order to delineate the most commonly detected drugs, approximately 1000 urine specimens from geographically distributed clinical laboratories were analyzed for drug substances. Twenty-nine (29) clinical laboratories submitted up to 76 consecutive urine specimens found to be positive for substances other than nicotine and caffeine. Specimens were analyzed by thin layer chromatography and special procedures for salicylates, benzoylecgonine, PCP, benzodiazepines, and cannabinoid metabolites. Every specimen was also tested for opiates, PCP, and cannabinoid metabolites by an enzyme immunoassay procedure. The total number of drugs detected in 1000 specimens was 3014, an average of three drugs per specimen; and 110 different drugs were identified. Of these, 50 drugs accounted for 95% of the total detected; 21% of the specimens contained cannabinoid metabolites, and 4% of the specimens contained cocaine and/or benzoylecgonine. Most of the specimens were routine, and only 4% originated from comatose patients.

Humans↗
PubMedDate not supplied

Three-dimensional surface rendering in MRI morphometry: a study of the planum temporale.

OBJECTIVE: The emergence of methodologies for accurately rendering cortical surfaces suggests possible quantitative applications of surface rendering to morphometry of the cerebral cortex. We examined this novel use of surface renderings in a study of the planum temporale, a neuroanatomical structure exhibiting well-documented normal asymmetry previously visible only in postmortem studies. MATERIALS AND METHODS: With the aid of three-dimensional renderings of the supratemporal cortex, the area of the planum temporal was analyzed in the volume MRIs of seven normal, strongly right-handed males. RESULTS: In comparison with areas derived from conventional measurements of serial MRI sections, planum temporale areas derived from supratemporal surface renderings offered far greater interrater reliability, and presumably improved validity as reflected by more consistent evidence of the anticipated planum asymmetry. CONCLUSION: Morphometry of the supratemporal cortex is enhanced by the use of three-dimensional surface renderings. Application of surface-rendering techniques to morphometry of other cortical regions is discussed.

Algorithms↗
PubMedDate not supplied

Therapeutic considerations in the treatment of obesity hypertension.

Obesity, now recognized as an independent risk factor for cardiovascular disease, is closely associated with hypertension. Complex mechanisms link increasing body weight with increasing blood pressure. Treatment of the obese patient with hypertension requires consideration of physiologic changes related to obesity hypertension. Lifestyle modification, including weight reduction and increased physical activity, can directly influence blood pressure levels and improve blood pressure control in obese, hypertensive patients. Clinical trials are needed to determine the most effective antihypertensive drugs for the obese, hypertensive patient. Antiobesity drugs offer viable adjunctive pharmacotherapy for obesity hypertension, but additional long-term studies are needed to support their safety and efficacy.

Adult↗
PubMedDate not supplied

Pennsylvania hospital continues to reduce seclusion and restraints.

Haverford State Hospital in Haverford, Penn, was one of three hospitals profiled in case studies of organizations that have made efforts to reduce their use of seclusion and restraints in the January/February 1996 issue of Perspectives. As a result of this article, the hospital received numerous requests for assistance and information about its practices from other health care organizations. Haverford State Hospital is a 300-bed inpatient care facility for the seriously and persistently mentally ill. During 1996, it continued its efforts to reduce the use of seclusion and restraints. In this On Site column, David W.P.Jones, assistant superintendent for quality assurance and risk management at Haverford State Hospital, shares information on the hospital's progress and provides some additional data.

Hospital Bed Capacity, 300 to 499↗
PubMedDate not supplied

Evaluating physical fitness for hazardous waste work.

The lifting of heavy loads is the most physically demanding aspect of many occupations. Clean-up work at hazardous waste sites involves heavy manual labor, frequently under significant thermal stress created by personal protective equipment. Worker fitness is particularly important in hazardous waste work in view of the increased demands required on the musculoskeletal and cardiopulmonary systems.

Hazardous Waste↗
PubMedDate not supplied

Hypertension in Korea: a national survey.

To determine the prevalence of hypertension (HTN) and its risk factors, we performed a population-based national cross-sectional blood pressure (BP) survey in Korea in 1990. Through cluster sampling, we selected for study individuals older than 30 years of age in 190 of 154,082 districts. Among 25,567 eligible individuals, 21,242 subjects had measurements of BP and body mass index (BMI) and underwent a standard interview. BP was recorded as the mean of two measurements on a standard mercury manometer. The prevalence of HTN varied widely by area of residence. Overall prevalence was 19.8% for HTN defined as BP > or = 140/90 mm Hg or subject on medication, and 12.4% for BP > or = 160/95 mm Hg or subject on medication. Correlates for HTN identified by logistic regression analysis included positive family history of HTN (odds ratio [OR] = 2.2,), age (10 years); OR = 1.9), alcohol intake (500 cc; OR = 1.4), urban location (versus rural; OR = 1.3), and BMI (1 BMI unit; OR = 1.2). [Am J Prev Med 1994;10:200-4]

Adult↗