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Biomedical subjects

D W Gelfand

Publications and source records attributed to D W Gelfand.

At least 37 records · Page 2Linked to original sources
PubMed1996

Functional abnormalities of the esophagus: a prospective analysis of radiographic findings relative to age and symptoms.

OBJECTIVE: The prevalence and severity of functional abnormalities of the esophagus seen on fluoroscopic examination were compared with the age and symptoms of the patients. SUBJECTS AND METHODS: The esophagus was examined radiographically in 139 consecutive outpatients 19-84 years old. All patients completed a data sheet about their symptoms, and medical records were reviewed to determine the main indication for the examination. Videofluoroscopy was used to evaluate primary peristalsis, proximal escape, and tertiary activity in the esophagus. The severity of proximal escape and activity was classified. RESULTS: Patients were categorized into three age groups: 39 years old or younger (n = 33); from 40 to 60 years old (n = 55); and 61 years old or older (n = 51). Abnormal esophageal motility, defined as disruption of peristalsis on two or more of five swallows, was found in 24% of patients 39 years old or younger, 36% of patients from 40 to 60 years old, and in 49% of patients 61 years old or older (p > .05). However, evaluation of the number of disrupted peristaltic swallows by age revealed 18% abnormal swallows in patients 39 years old or older, 27% in patients from 40 to 60 years old, and 37% in patients 61 years old or older (p < .01). Proximal escape and tertiary contractions increased significantly with the age of the patient. Regardless of age, proximal escape was seen in 79% of swallows and tertiary contractions were seen in 48% of swallows with disrupted peristalsis. The prevalence and severity of proximal escape and tertiary contractions increased in the older patients. Symptoms had no correlation with status of esophageal motility (p > .05). In 22 patients with secondary diseases, including rheumatoid arthritis and diabetes mellitus, those diseases showed no correlation with the status of esophageal motility. CONCLUSION: The prevalence of functional abnormalities of the esophagus increased with age. Most patients with abnormal swallows showed proximal escape with or without tertiary activity. Patients' symptoms and other diseases did not correlate with the status of their esophageal motility.

Adult↗
PubMed1996

Correlation of lower esophageal mucosal ring and 24-h pH monitoring of the esophagus.

OBJECTIVE: To study the relationship of LEMR and gastroesophageal reflux. The pathogenesis of the lower esophageal mucosal ring (LEMR) is not known. The most likely theory is that the ring results from reflux esophagitis as part of the morphological spectrum of peptic stricture. METHODS: We correlated barium esophagrams and 24-h pH monitoring (pHM) in 343 patients (173 women, 170 men; mean age 52 yr). Patients were categorized into three groups by radiographic findings: 1) normal esophagus (n = 121), 2) hiatal hernia (HH) only (n = 174), and 3) LEMR (n =48). Abnormal pHM was defined as a total percentage of the esophageal acid exposure time of 6% or more; abnormal pHM was also analyzed relative to patient position (supine vs. upright). RESULTS: Findings showed that 21 (17%) of 121 normal patients had abnormal pHM compared with 58 (33%) of 174 patients with HH and 15 (31%) of 48 patients with LEMR. Normal patients had a significantly lower frequency of abnormal pHM (p < 0.01) vs. the other two groups; however, no significant difference in results of pHM was found in the groups with HH and LEMR. No significant relationships of abnormal supine versus upright pHM was observed comparing the three groups. CONCLUSIONS: 1) Most patients in this study had normal pHM, regardless of the anatomic status of the esophagogastric region; 2) patients with HH and LEMR had a higher frequency of abnormal pHM, although the two groups were not significantly different; and 3) an etiological relationship of LEMR and gastroesophageal reflux was not supported, other than its association with HH.

Esophagogastric Junction↗
PubMed1995

Association of hiatal hernia and gastroesophageal reflux: correlation between presence and size of hiatal hernia and 24-hour pH monitoring of the esophagus.

OBJECTIVE: The relationship of hiatal hernia to gastroesophageal reflux disease remains controversial. Previous endoscopic and radiologic studies of hiatal hernia and reflux esophagitis have shown that hiatal hernia is a poor predictor of the presence of endoscopic esophagitis, especially for smaller hernias. Similar correlations with 24-hr pH monitoring have not been done. The purpose of this study was to determine if there is a correlation between the presence and size of hiatal hernias and gastroesophageal reflux using 24-hr pH monitoring as a measure of the degree of reflux. MATERIALS AND METHODS: We reviewed the barium esophagograms and the results of pH monitoring of the esophagus in 319 patients (161 women and 158 men; mean age, 51 years). The presence and size of hiatal hernia were determined from the radiographic examination; size was categorized as "minimal" or "larger" (> or = 2 cm axial length). An abnormal result of pH monitoring was defined as a pH less than 4 for 6% or more of the 24-hr observation time. RESULTS: Abnormal results of pH monitoring were found in 61 (31%) of 199 patients with hiatal hernia compared with 21 (18%) of 120 patients without hiatal hernia (p < .05). Abnormal findings of pH monitoring were present in 33 (35%) of 95 patients with a larger hiatal hernia versus 28 (27%) of 104 patients with a minimal hiatal hernia (p > .05); a significant difference (p < .05) was observed when patients without hiatal hernia were compared with those with a larger hiatal hernia. CONCLUSION: Most patients in this study had normal results of pH monitoring of the esophagus regardless of the presence or absence of hiatal hernia. However, patients with larger hiatal hernias were more likely to have abnormal findings on pH monitoring; hiatal hernias of minimal size were a poorer predictor of the presence of abnormal gastroesophageal reflux.

Esophagus↗
PubMed1995

Intramural pseudodiverticulosis of the esophagus detected on barium esophagograms: increased prevalence in patients with esophageal carcinoma.

OBJECTIVE: We tested the hypothesis that intramural pseudodiverticulosis of the esophagus is more prevalent in patients with esophageal carcinoma than in randomly selected patients who undergo esophagography for other indications. Such an association would prompt a careful search for carcinoma after esophageal intramural pseudodiverticulosis is found. MATERIALS AND METHODS: Single- and double-contrast esophagograms of 245 patients with esophageal carcinoma were retrospectively reviewed. A control group of 6400 esophagograms obtained for indications other than esophageal carcinoma was also reviewed. The statistical significance of the difference in prevalence of esophageal intramural pseudodiverticula between patients with esophageal carcinoma and the control group was tested using the chi-square test. The significance of difference between the number of esophageal intramural pseudodiverticula in patients with esophageal dilatation and the number in those without dilatation was tested using a small-sample nonparametric test. RESULTS: Intramural pseudodiverticulosis of the esophagus was found in 11 patients with esophageal carcinoma (4.5%) and in six control subjects (0.09%). Intramural pseudodiverticulosis of the esophagus was present opposite the tumor as well as both proximally and distally. The number of cases of intramural diverticulosis in patients with esophageal carcinoma and dilatation was not significantly higher than that in patients with carcinoma but without dilatation (p > .1) CONCLUSION: The prevalence of esophageal intramural pseudodiverticulosis is significantly higher in patients with esophageal carcinoma than in patients who underwent esophagography for other indications (p < .0002). This association implies increased risk of esophageal carcinoma in patients with intramural pseudodiverticulosis. Periodic surveillance of patients with intramural pseudodiverticulosis of the esophagus for esophageal carcinoma may be worthwhile.

Adult↗
PubMed1994

Correlation of lower esophageal mucosal ring and lower esophageal sphincter pressure.

We assessed the relationship of lower esophageal sphincter pressure (LESP) to presence and absence of lower esophageal mucosal ring (LEMR) in 66 patients to determine if the LEMR was more likely related to prolonged sphincter hypotension. This potential relationship is of interest because LEMR may be due to reflux esophagitis. Each patient had radiographic and manometric studies, and both examinations were done within one week of each other. The mean LESP in patients with LEMR was 23.8 mm Hg (range 4.2-64 mm Hg) compared to 28.7 mm Hg (range 8-59 mm Hg) in patients without LEMR; the difference was not statistically significant. Patients with LEMR were also divided into three subgroups according to the diameter of the rings (< or = 13 mm, 14-19 mm, > or = 20 mm). There was no significant relationship between the caliber of LEMR and LESP (P > 0.05). Presence of LEMR did not affect the amplitude or duration of primary esophageal peristalsis. These results do not support a relationship between LEMR and prolonged LESP hypotension or abnormal esophageal motility. However, other pathogenetic mechanisms involved in producing reflux esophagitis not related to prolonged sphincter hypotension were not studied.

Esophageal Motility Disorders↗
PubMed1994

Cost-effective filming sequence for intravenous urography.

To define an intravenous urography (IVU) film sequence that maximizes sensitivity and minimizes filming costs, we evaluated the effect of omitting films from a standard IVU sequence. We reviewed 82 IVU series that demonstrated abnormalities. Each series comprised 11 films: preliminary abdominal radiograph and nephrotomogram, three 1-minute nephrotomograms, 5-minute abdominal film, 10-minute radiograph with abdominal compression, one frontal and two oblique 15-minute films, and postvoid film. Sensitivity was determined for each film. Eighty-two standard IVUs showed 120 abnormalities. Omitting any one film from the sequence decreased sensitivity by 0% to 12%. Omitting the preliminary film resulted in failure to detect 15 abnormalities (12%). Omitting any nephrotomogram, the 10-minute compression view, or either 15-minute oblique film did not decrease sensitivity. Omitting combinations of these films lowered overall sensitivity. The postvoid film was essential in only one case. We conclude that a sequence of nine radiographs decreases film and processing expenses by 18% without sacrificing sensitivity. Sequences with fewer films substantially reduce detection of common urinary tract abnormalities.

Cost-Benefit Analysis↗
PubMed1994

The multiphasic upper gastrointestinal examination.

The upper gastrointestinal series traditionally includes fluoroscopy and filming of the esophagus, stomach, and duodenum. Optimal use of each of the available examination techniques in these regions is discussed in this article.

Duodenum↗
PubMed1994

Achalasia associated with esophageal diverticula. Prevalence and potential implications.

Although esophageal diverticula have been rarely reported in patients with achalasia, their prevalence and the potential implications of the relationship are not well known. We reviewed the medical records and the manometric and radiographic examinations in 120 patients with achalasia to determine the prevalence of esophageal diverticula and to evaluate their importance in this motility disorder. Esophageal diverticula were found in only 6 (5%) of 120 patients, and all were located in the lower half of the esophagus. Sex distribution and the prevalence of dysphagia and regurgitation, which affected all patients with diverticula and 88% of those with achalasia only, were not different significantly. Patients with esophageal diverticula were significantly older (72 vs. 52 years) than those without diverticula. In 5 of 6 patients with diverticula, mean lower esophageal sphincter (LES) pressure was 44.5 mm Hg compared to 39.1 mm Hg in 86 of 114 patients with achalasia only. Treatment by pneumatic dilatation was done in 4 patients with esophageal diverticula and in 105 patients without diverticula. Five esophageal perforations occurred, all in patients without esophageal diverticula.

Adolescent↗
PubMed1993

Achalasia associated with hiatal hernia: prevalence and potential implications.

Although hiatal hernia is reported with a 40-50% frequency in the general population, its occurrence and potential implications in achalasia are less well known. We reviewed the medical records and radiographic examinations of 120 patients with achalasia to assess the prevalence of hiatal hernia and its importance in evaluation and management of this motility disorder. Hiatal hernia was present in only 10 (8.3%) patients. Age, sex distribution, prevalence of dysphagia and regurgitation, and lower esophageal sphincter pressure measured manometrically were not significantly different in patients having hiatal hernia compared to those without hernia. Most patients (88%) underwent pneumatic dilatation and five esophageal perforations occurred, but all in patients without hiatal hernia. In conclusion, hiatal hernia is uncommon in patients with achalasia for reasons not known. Age, sex, symptoms, and results of esophageal manometry were not significantly different in those with hiatal hernia. Finally, the presence of hiatal hernia is not a contraindication to treatment of achalasia by pneumatic dilatation.

Adolescent↗
PubMed1993

Compression filming with high-density barium suspensions.

A method is described for use of high-density barium suspension (250% wt/vol) during compression filming performed in conjunction with the double-contrast examination of the stomach. The technique employs control of the distribution of barium within the stomach by table tilting and use of the vertebral column to stabilize the posterior wall of the stomach. The technique allows routine demonstration of the area gastricae and gastric erosions on compression films, as well as detection of anterior wall lesions that may be undetected by double-contrast films.

Barium Sulfate↗
PubMed1993

Postoperative hysterosalpingography. Radiographic appearances and clinical results following tubal surgery.

Medical records and postoperative hysterosalpingograms on 23 women following tubal surgery who failed to become pregnant within 2-28 months were reviewed. A total of 39 tubes were analyzed. The surgical indications were reversal of tubal ligation in 24 tubes and correction of tubal or perifimbrial disease in 15 tubes. Tubal ligation had been performed by a variety of methods. At surgery, tubal patency, as shown by chromotubation, was seen in 37 (95%) of 39 tubes. On postoperative hysterosalpingography, tubal spillage was present in 32 (82%) of 39 tubes. Radiographically, the tubes that spilled appeared normal except for occasional shortening after reversal of tubal ligation. The eventual pregnancy rate was 8 (35%) of 23 patients, with 7 intrauterine. Pregnancy occurred only in women under 35 years and was more likely in the group having reversal of tubal ligation. We conclude that among patients who do not initially become pregnant following tubal surgery for infertility, tubal patency is restored in most. During hysterosalpingography, tubes operated on may appear normal or shortened. On long-term follow-up, younger patients and those requiring tubal anastomosis only had a higher pregnancy rate.

Adult↗
PubMed1992

Clinical and videofluoroscopic evaluation of swallowing in 41 patients with neurologic disease.

Forty-one patients with neurologic disease (ND) were evaluated by clinical and videofluoroscopic examination of the oral cavity and pharynx to assess location and severity of swallowing dysfunction using various bolus consistencies. Four different materials were given to each patient, and included low- and high-viscosity barium suspensions, barium paste, and paste-coated cookie. Thirty-five patients had abnormalities of both oral and pharyngeal function. Four patients had pharyngeal dysfunction only, and two patients were normal. Mild swallowing difficulties occurred in five patients (12%), moderate dysfunction in 29 patients (71%), and severe dysfunction in five patients (12%). Thirty-two patients had pharyngeal stasis, which was symmetric in 30 patients (94%) and asymmetric in two. Site of stasis was not related to the type of neurologic disease. Fifteen patients aspirated, most of them (13 of 15) with the low-viscosity barium suspension. The predominance of aspiration with the low-viscosity liquid emphasizes the importance of clinical and videofluoroscopic evaluation of swallowing in dysphagic patients with ND for appropriate feeding recommendations. Thus, videofluoroscopy complemented the clinical examination and defined the type and severity of swallowing abnormalities and aspiration, when present.

Amyotrophic Lateral Sclerosis↗