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Biomedical subjects

D W Fortune

Publications and source records attributed to D W Fortune.

At least 55 records · Page 3Linked to original sources
PubMed1980

Diagnosis of cervical epithelial abnormalities from 'routine' uterine curettings.

Fragments of cervical tissue are frequently found in uterine curettings. These may consist of endocervical mucosa, squamous epithelium, or both. To determine the frequency of abnormalities in this epithelium, 4000 consecutive endometrial curettings were examined during the year ending December 1977. Abnormal squamous epithelium was found in 20 cases (0.5%). The abnormalities were defined for the purpose of the study to include dysplasia/carcinoma in situ and warty atypia. Cases in which endometrial curettage was performed during the work-up for known dysplasia or carcinoma in situ were excluded. Subsequent follow-up included cytology, colposcopy, and colposcopically-directed target biopsies; occasionally conization and hysterectomy were performed. The most significant abnormality detected in this way was carcinoma in situ with early stromal invasion. The definitive treatment in most cases was cervical diathermy. As the abnormalities in the initial scrapings were previously unsuspected, it is imperative for the anatomic pathologist to look for and carefully evaluate cervical fragments in all endometrial curettings.

Adult↗
PubMed1978

Congenital cystic adenomatoid malformation of the lung.

Ten cases of congenital cystic adenomatoid malformation of the lung are presented, together with a review of the literature. Two infants were stillborn; the others died shortly after birth. Eight had hydrops, and in eight the pregnancy was complicated by hydramnios. Grossly, one or two lobes of the lung were affected, the remaining lobe(s) and the opposite lung being hypoplastic. The lesions were solid, or cystic. Apart from a solitary cutaneous hamartoma, there was no associated anomaly. Microscopically, two patterns were seen--solid and mixed. "Mucigenic epithelium" was seen in six cases. The pathogenesis of this lesion, together with that of the hydrops and hydramnios, is discussed. It is concluded that congenital cystic adenomatoid malformation of the lung is a distinct pathological entity; its prompt recognition and surgical correction should result in normal survival.

Edema↗
PubMed1978

Bilateral pulmonary agenesis.

Two cases of bilateral pulmonary agenesis in infants of 31 and 41 weeks gestation are reported. In addition to absence of both lungs, major abnormalities not previously reported were also found in other systems. It is concluded that these abnormalities are not due to chromosomal abnormality but no alternative can be offered.

Abnormalities, Multiple↗
PubMed1977

Malformations in infants of very low birth weight.

The incidence of lethal, serious and trivial malformations was determined in a consecutive series of 675 infants who weightd 1500 g or less (very low birth weight infants). All patients were born in one maternity hospital. Most of the 169 survivors were followed until at least five years of age. Of these children, 15 had a trivial malformation that either disappeared spontaneously or was corrected surgically. A further five children have a significant or serious residual defect. There were 506 perinatal and infant deaths and 51 of the babies who died had malformations confirmed at necropsy. In 30 of these, death was inevitable. There were 10 seriously malformed infants for whom survival was possible, but in six cases, the diagnosis was obvious at birth. The patients were treated between 1966 and 1970 when techniques of intensive care were evolving. Consequently, some of the infants who died would have survived with the treatment now available. Amongst the perinatal deaths in this report, only 2.0% had a serious malformation compatible with survival.

Australia↗