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Biomedical subjects

D W Crook

Publications and source records attributed to D W Crook.

42 records · Page 3Linked to original sources
PubMed1988

Antimicrobial resistance in oral and colonic bacteroides.

Antimicrobial resistance in Bacteroides from oral and colonic flora influences the selection of antimicrobial therapy to treat infections involving these organisms. An antimicrobial susceptibility study of 49 clinical isolates of oral bacteroides to 9 drugs revealed high resistance rates for penicillin 53%, for cefaclor 45%, and for tetracycline 27%, while there were low rates (less than 10%) with cefoxitin, piperacillin, clindamycin, chloramphenicol and metronidazole. Review of our U.S. nationwide survey of the susceptibility of colonic bacteroides (Bacteroides fragilis group) reveals low resistance to clindamycin, cefoxitin, piperacillin, imipenem, chloramphenicol and metronidazole. However, the identification of clindamycin, clindamycin, cefoxitin, piperacillin, imipenem and chloramphenicol resistant isolates is worrisome. The mechanism of resistance and the resistant transfer mechanism to the different classes of drugs in the oral and colonic bacteroides are reviewed.

Bacteroides↗
PubMedDate not supplied

Primary neuroendocrine tumors of the liver: MRI features in two cases.

We report on two patients who underwent magnetic resonance imaging (MRI) as part of the evaluation of focal liver lesions. Both lesions had completely different MRI appearances, showing characteristics of benign and malignant liver lesions. Neither patient had clinical signs of endocrine hyperactivity, and both underwent subsequent liver resection. Histology showed neuroendocrine liver tumors in both patients; and because no primary tumor could be identified after careful search, the diagnosis of primary neureoendocrine tumor of the liver was established. Our observations suggest that primary neuroendocrine tumors of the liver may have a wide spectrum of appearances on MRI.

Female↗
PubMedDate not supplied

Outcome following staphylococcal peritonitis.

OBJECTIVE: Staphylococcus spp predominate as the causative pathogen of continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis.This study evaluated the difference in morbidity and mortality between peritonitis caused by S. aureus and coagulase-negative staphylococci (CoNS). DESIGN: Prospective observational study. SETTING: A single regional dialysis unit in a teaching hospital. PATIENTS: Thirty-seven patients had S. aureus peritonitis and 65 patients had CoNS peritonitis between July 1990 and November 1995. MAIN OUTCOME MEASURES: Using the first recorded episode of peritonitis, survival analysis was performed for time to (1) death, (2) removal of peritoneal dialysis catheter, and (3) change to hemodialysis. Abdominal complications were recorded for the first and subsequent episodes. RESULTS: No difference in time to death was demonstrated for the two groups (p = 0.79), although two deaths that occurred during therapy for peritonitis were attributable to S. aureus infection. In addition, 5 patients developed serious abdominal complications related to an episode of S. aureus peritonitis. Patients with S. aureus peritonitis had a shorter time to both peritoneal dialysis catheter removal (p = 0.004) and change to hemodialysis (p = 0.014). The change in mode of dialysis was independent of catheter loss. CONCLUSION: This study highlights the serious nature of S. aureus peritonitis and confirms the need for effective preventive measures against infection by this pathogen.

Adult↗