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Biomedical subjects

D W Barritt

Publications and source records attributed to D W Barritt.

36 records · Page 2Linked to original sources
PubMed1977

Practolol peritonitis. A study of 16 cases and a survey of small bowel function in patients taking beta adrenergic blockers.

Sixteen patients with practolol peritonitis are described. Dense peritoneal thickening and adhesions caused small bowel stasis and obstruction with characteristic radiology and histology. The disease was best treated by surgery though complications were frequent and three of 16 patients died. Ocular and skin involvement were common. Fifty four asymptomatic patients who had taken a beta adrenoceptor blocking drug for more than 12 months were studied. Seven were found to have radiological abnormalities of the small bowel. These changes were associated with propranolol, oxprenolol and practolol therapy. It is not known whether they are related to practolol peritonitis.

Aged↗
PubMed1976

Raynaud's phenomenon as side effect of beta-blockers in hypertension.

A series of 102 hypertensive patients were assessed for the frequency of symptoms of Raynaud's phenomenon and absent peripheral pulses. Out of 21 patients receiving methyldopa alone only one had cold hands and feet whereas among patients on beta-blockers the incidence was 50%. The frequency of both symptoms and absent pulses was highest in patients taking propranolol compared with those taking atenolol or oxprenolol. Patients without a foot pulse were much more likely to have cold hands. A change from propranolol to oxprenolol in some symptomatic patients resulted in improvement. In two patients the skin temperature fell after an 80-mg dose of propranolol. The mechanism by which beta-blockers induce Raynaud's phenomenon is still not clear.

Adrenergic beta-Antagonists↗
PubMed1976

Comparison of oxprenolol and methyldopa in hypertension. A within-patient double-blind trial.

Oxprenolol or methyldopa were administered in double-blind fashion to 29 patients shown to be persistently hypertensive. After a dose-finding, assessment, and washout period, the second drug was given. 24 patients completed a period of treatment with each drug. Blood-pressure falls were similar with each drug in the supine, standing, and post-exercise state. Half the patients responded will to low dosage (oxprenolol less than or equal to 320 mg, methyldopa less than or equal to 1 g, a day) and 9 of 11 such patients responded satisfactorily to each drug. In those whose response was inadequate, oxprenolol was increased to 960 mg or methyldopa to 3 g a day. Increasing dosage had no consistent pressure-lowering effect. Side-effects were assessed by questionnaire and no clear preference emerged. It is recommended that an inadequate response to modest dosage of either drug should lead to the use of an additional agent rather than heavier dosage.

Adult↗
PubMed1975

Echocardiographic assessment of severity of aortic regurgitation.

An echocardiographic study of left ventricular diameter was made in 27 patients with aortic regurgitation. Comparison was made with a group of 21 normal subjects and a group of 6 patients with large left ventricles without valvar regurgitation. Total stroke volume, total left ventricular output, and ejection fraction were derived by the method of cubing the left ventricular diameter to give approximate left ventricular volumes at and-diastole and end-systole. The patients were assessed independently and placed into three grades of severity. The eechocardiographic dimensions of patients with mild aortic regurgitation were not significantly different from those of the normal subjects. With increasing severity of aortic regurgitation, there were increases in group values for left ventricular diameter, total stroke volume, and total left ventricular output. The ejection fraction was depressed below the normal range in only one patient with aortic regurgitation. It is concluded that echocardiographic measurement of left ventribular dimensions is of value in assessing the severity of aortic regurgitation.

Adolescent↗
PubMed1970

Late results of aortic valve replacement with the Starr-Edwards prosthesis.

Details are presented concerning 59 patients who left hospital between January 1964 and January 1969 after aortic valve replacement with the Starr-Edwards prosthesis. Of the 14 late deaths, 7 are known to have been due to causes related to the prosthesis and 4 to other causes. The 45 surviving patients have nearly all shown clinical improvement and only 3 are unable to work as a result of some complication of the operation. Aortic regurgitation and its consequences appear to be the most significant factor leading to symptoms. In 11 of 16 patients with anaemia there was evidence of intravascular haemolysis. The long-term consequence of this complication is not known.

Adult↗