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Biomedical subjects

D Voigt

Publications and source records attributed to D Voigt.

At least 19 recordsLinked to original sources
PubMed2001

Biomechanical properties of quadruple tendon and patellar tendon femoral fixation techniques.

Two femoral fixation techniques for quadruple hamstring tendon grafts were compared under cyclic loading with the patellar tendon: the rectangular inserted pin (TransFix) and biodegradable interference screw fixation of the quadruple tendon and titanium interference screw fixation of the middle third of the patellar tendon. Porcine specimens were mounted onto a tension load machine, and the tendon-fixation-femur-complex was tested for stiffness, displacement during 800 cycles of loading between 50 and 250 N and ultimate tension load. TransFix fixation showed the greatest stiffness at 183.6 N/mm ( P<0.05). The least displacement under cyclic loading was observed for the titanium interference screw followed by the TransFix and biodegradable interference screw ( P<0.01). The ultimate tension load was greatest for the TransFix fixation at 1303+/-282 N, followed by patellar tendon fixation with 763+/-103 N and the biodegradable interference screw fixation with 480+/-133 N ( P<0.001). To reduce initial elongation of the graft and displacement at the fixation site, preconditioning of both the tendon and tendon-fixation complex is especially important when using quadruple tendons. TransFix fixation provides better stability and greater stiffness and pull-out strength than the other techniques. This finding is of clinical relevance to surgeons of the anterior cruciate ligament.

Absorbable Implants↗
PubMed1994

Differences in intravenous and subcutaneous application of recombinant human erythropoietin: a multicenter trial.

The aims of this clinical study were to compare the maintenance doses for intravenous (i.v.) and subcutaneous (SC) administration of recombinant human erythropoietin (rhEPO) and to investigate whether there is any difference in the increase of the packed cellular volume (PCV) per week under i.v. and SC administration of rhEPO from two production sites (Genetics Institute, Cambridge, USA; and Boehringer Mannheim, Penzberg, Germany). A total of 90 patients suffering from end-stage renal disease were included in the study. All patients had already been treated for at least 6 months with chronic hemodialysis. The study was carried out as a randomized, multicenter parallel group comparison study with a 1-week pretreatment phase, a subsequent 8-week double-blind phase, and a final open phase. The final open phase consisted of a correction phase and a maintenance phase. The production site had no influence on the PCV increase per week, and there were no differences with respect to tolerability. The median rhEPO dose required to maintain the target PCV of 30 to 35 vol.% was 33 U/kg body weight three times a week in the i.v. group compared with 22 U/kg in the SC group (i.e., an average of 30% less with SC administration). Development or aggravation of hypertension under rhEPO therapy was observed, especially during the correction phase and more frequently in the SC group than in the i.v. group. During the maintenance phase, there was no essential difference between the two groups.

Adult↗
PubMed1986

Arbovirus infections in several Ontario mammals, 1975-1980.

Serological studies for arboviruses were conducted on 725 animal sera collected in 22 Ontario townships between 1975 and 1980 including 44 coyote (Canis latrans), 277 red fox (Vulpes vulpes), 192 raccoon (Procyon lotor) and 212 striped skunk (Mephitis mephitis). Hemagglutination inhibition antibodies to two flaviviruses, namely St. Louis encephalitis and Powassan were found in 50% of coyote, 47% of skunk, 26% of fox and 10% of raccoon sera. Similarly, hemagglutination inhibition antibodies to a California serogroup virus, snowshoe hare, were found in 12% of fox, 7% of skunk, 7% of raccoon and 5% of coyote sera. No antibodies were detected to two alphavirus, namely eastern equine encephalitis and western equine encephalitis, antigens. This study affirms the endemic presence of Powassan and snowshoe hare virus and further delineates the scope of St. Louis encephalitis activity in Ontario.

Animals↗
PubMed1978

Mass spectroscopy of natural products. III--Mass spectrometric comparison of lysergic acid and 9,10-dihydrolysergic acid.

The influence of the 9,10-double bond in the ergoline skeleton on the fragmentation behaviour of lysergic acid and 9,10-dihydrolysergic acid is discussed. The main fragmentation pathways were determined using high resolution mass spectrometry and metastable ion studies. The 70 eV electron impact spectra are compared with the 12 eV electron impact spectra and the negative ion mass spectra (2--4 eV).

Ergolines↗