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Biomedical subjects

D Vitale

Publications and source records attributed to D Vitale.

45 records · Page 3Linked to original sources
PubMedDate not supplied

Direct coronary vasodilator effects of intracoronary histamine administration in humans.

Histamine is widely present in human tissues and can be released by immunologic and nonimmunologic reactions. Although several direct cardiovascular effects of histamine have been demonstrated in humans, little is known about the direct effects of histamine on the human coronary circulation in vivo. Therefore, we investigated the changes in coronary hemodynamics induced by bolus intracoronary administration of 4 micrograms of histamine to 11 patients with angiographically normal coronary arteries under continuous monitoring of R-R interval from the electrocardiogram, arterial pressure (AP), and coronary sinus blood flow (CBF), measured by thermodilution. Immediately after the end of the intracoronary histamine bolus, with R-R interval and AP unchanged, CBF increased from 144 +/- 20 to 238 +/- 27 ml/min (p less than 0.01) and coronary vascular resistance decreased from 0.7 +/- 0.16 to 0.42 +/- 0.1 mm Hg/ml/min (p less than 0.01). No change in coronary hemodynamics was observed after bolus intracoronary administration of physiologic saline. The effects of histamine on systemic hemodynamics consisted of a transient fall in AP and R-R interval, starting after the onset of changes in coronary hemodynamics. These data show that histamine possesses a direct coronary vasodilator effect in humans, independent of the determinants of myocardial oxygen consumption.

Adult↗
PubMedDate not supplied

[Surgical treatment of epiphrenic diverticulum based on associated functional changes: report of a case].

OBJECTIVE: The authors report their experience about the surgical treatment of a epiphrenic diverticulum (ED) associated with motor disfunctions and gastroesophageal reflux. DESIGN: Report of 1 case; evaluation of effectiveness of the treatment. SETTING: Operative Unit of General and Thoracic Surgery, Department of Surgical, Anatomical and Oncological Disciplines. Policlinico, University of Palermo. INTERVENTIONS: Thoracotomic diverticulectomy + esophageal extramucosal myotomy + antireflux procedure. RESULTS: Resolution of syntomatology. Negative the follow up. CONCLUSIONS: ED is the epiphenomenon of esophageal motor disfunctions. The surgical procedure is based on their comprehension and on the study of this factors.

Diverticulum, Esophageal↗
PubMedDate not supplied

[Endoscopic treatment of pancreatic pseudocysts. Our experience in 8 cases].

OBJECTIVE: The authors report their experience about the endoscopic treatment of pancreatic pseudocysts (PP). DESIGN: Report of 8 cases; evaluation of effectiveness, morbidity and mortality. SETTING: Operative Unit of General and Thoracic Surgery, Department of Surgical, Anatomical and Oncological Disciplines. Policlinico, University of Palermo. INTERVENTIONS: endoscopic drainage in all 8 patients. RESULT: 88% successful (7/8). CONCLUSION: Endoscopic drainage of PP is a safe and simple treatment, with high rates of success and low rate of morbility.

Cholangiopancreatography, Endoscopic Retrograde↗
PubMedDate not supplied

cGMP phosphodiesterase activity evaluation in human carcinoma of salivary glands.

The aim of this study was to evaluate differences of cGMP-PDE activity in salivary glands, between a control group and different benign tumour groups and, where present, with malign tumour groups. Endogen cGMP was evaluated too. The enzymatic reaction used the method of Spoto et al., with minor variations. The samples were organized in six groups: A (Adenolymphoma and Warthins tumour); B (Pleomorphic Adenoma); C (Basaloid Adenoma); D (Myoepitelioma). The control group was represented by healthy patients. In A and B groups, we have analyzed malign pathologies (Adenocarcinoma and Parotid Lymphoma) The benign tumours have more activity than controls, especially in Myoepitelioma (D) but with a decrement in the C group, which presents lower values of cGMP than the other three groups, where the concentration is similar. Between A and B groups, the activity values of malign tumours are similar, higher than controls and than the other benign pathologies, but not higher than in myoepitelioma. The cyclic concentration is similar for malign pathologies, with concentrations lower than controls, similar to Basaloid Adenoma (C).

3',5'-Cyclic-GMP Phosphodiesterases↗
PubMedDate not supplied

Electrical and mechanical actions of magnesium sulfate during ischemia and reperfusion on isolated perfused rat heart.

Experimental and clinical studies have shown the action of magnesium salts on myocardial tissue and its antiarrhythmic action on digitalis-induced ventricular arrhythmias. We have evaluated the effects of magnesium sulfate (2.5 mM) on heart rate (HR), coronary flow rate (CFR), left ventricular systolic pressure (LVSP), dP/dt max and voltage epicardial electrogram (VEE) during ischemia and reperfusion in isolated perfused rat heart. Forty-five male rats were randomized into 3 groups. In the control group, after a 15 min period of stabilization, hearts were perfused by ischemic perfusion for 30 min and then reperfused. In group I, magnesium sulfate was given after stabilization and before the ischemic period. In group II, calcium concentration was increased by 0.5 mM and magnesium sulfate was given after stabilization and before the ischemic period. In the control group, we observed during ischemia a reduction in HR, CFR, LVSP, dP/dt max and an increase in VEE. In group I, after the administration of magnesium sulfate, we noted a decrease in HR, LVSP, dP/dt max, VEE and during the ischemic period there was no difference in these parameters with respect to the control group. In group II, the increase of extracellular calcium concentration caused an increase in LVSP, dP/dt max and the administration of magnesium sulfate abolished these effect, bringing the values back to basal values. Reperfusion provoked ventricular arrhythmias in 11/15 and 12/15 hearts in the control group and group II respectively, and only 3/15 in group I (p less than 0.005 group I vs control and group II). Thus, our results demonstrated that magnesium sulfate has varied effects on electrical and mechanical parameters and prevents reperfusion arrhythmias according to the hypothesis of a calcium-antagonist mechanism of magnesium.

Animals↗
PubMedDate not supplied

Comparison of the sedative effectiveness of two pharmacological regimens.

This study was designed to evaluate the effectiveness of two orally administered pharmacological regimens. The subjects were twenty-six patients requiring a sedative premedication for dental treatment, due to difficult behavior. A randomized, double-blind, cross-over design was employed using chloral hydrate syrup, 30 mg/Kg; and diphenhydramine HCl, 1.5 mg/Kg orally, not to exceed 2,000mg and 75mg, respectively; and chloral hydrate syrup, 30 mg/Kg; and diazepam solution, 0.2 mg/Kg orally, not to exceed 2000mg and 10mg, respectively. The level of conscious sedation was assessed, utilizing two scales employed previously in other studies. It was demonstrated that it is possible to maintain a low-dose range of sedative medication with satisfactory results. The combination of diazepam and chloral hydrate was found to be more effective than the diphenhydramine, chloral hydrate combination.

Adult↗